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    Trip12 thyroid hormone receptor interactor 12 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 316575, updated on 9-Dec-2024

    Summary

    Official Symbol
    Trip12provided by RGD
    Official Full Name
    thyroid hormone receptor interactor 12provided by RGD
    Primary source
    RGD:1306607
    See related
    EnsemblRapid:ENSRNOG00000016963 AllianceGenome:RGD:1306607
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Gtl6; TRIP-12
    Summary
    Predicted to enable nuclear thyroid hormone receptor binding activity and ubiquitin protein ligase activity. Predicted to be involved in several processes, including chromatin remodeling; proteasome-mediated ubiquitin-dependent protein catabolic process; and protein polyubiquitination. Predicted to be located in nucleoplasm. Predicted to be active in nuclear speck. Human ortholog(s) of this gene implicated in Clark-Baraitser syndrome. Orthologous to human TRIP12 (thyroid hormone receptor interactor 12). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Testes (RPKM 540.0), Kidney (RPKM 380.5) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Trip12 in Genome Data Viewer
    Location:
    9q35
    Exon count:
    46
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (93364791..93491015, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (85916691..86043312, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (92305059..92435388, complement)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene delta/notch-like EGF repeat containing Neighboring gene uncharacterized LOC120094725 Neighboring gene uncharacterized LOC134480598 Neighboring gene F-box protein 36 Neighboring gene uncharacterized LOC102550706 Neighboring gene uncharacterized LOC120094727 Neighboring gene solute carrier family 16, member 14

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC124674, MGC125132

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables nuclear thyroid hormone receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables ubiquitin protein ligase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ubiquitin protein ligase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables ubiquitin protein ligase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in DNA damage response IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in DNA repair IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in DNA repair-dependent chromatin remodeling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in DNA repair-dependent chromatin remodeling ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in heterochromatin boundary formation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in heterochromatin boundary formation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in protein polyubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in protein polyubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein polyubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of embryonic development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of embryonic development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of embryonic development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in ubiquitin-dependent protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in ubiquitin-dependent protein catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    is_active_in nuclear speck IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nuclear speck IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    E3 ubiquitin-protein ligase TRIP12
    Names
    HECT-type E3 ubiquitin transferase TRIP12
    TR-interacting protein 12
    gene trap locus 6
    probable E3 ubiquitin-protein ligase TRIP12
    thyroid receptor-interacting protein 12
    NP_001026829.2
    XP_006245441.1
    XP_006245442.1
    XP_008765474.1
    XP_017451976.1
    XP_017451977.1
    XP_038939631.1
    XP_038939637.1
    XP_038939639.1
    XP_038939640.1
    XP_063123308.1
    XP_063123309.1
    XP_063123310.1
    XP_063123311.1
    XP_063123313.1
    XP_063123314.1
    XP_063123315.1
    XP_063123316.1
    XP_063123317.1
    XP_063123318.1
    XP_063123319.1
    XP_063123320.1
    XP_063123321.1
    XP_063123323.1
    XP_063123324.1
    XP_063123325.1
    XP_063123326.1
    XP_063123327.1
    XP_063123328.1
    XP_063123329.1
    XP_063123331.1
    XP_063123332.1
    XP_063123333.1
    XP_063123334.1
    XP_063123335.1
    XP_063123336.1
    XP_063123337.1
    XP_063123338.1
    XP_063123339.1
    XP_063123340.1
    XP_063123341.1
    XP_063123342.1
    XP_063123343.1
    XP_063123344.1
    XP_063123345.1
    XP_063123346.1
    XP_063123347.1
    XP_063123348.1
    XP_063123349.1
    XP_063123350.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001031659.4NP_001026829.2  E3 ubiquitin-protein ligase TRIP12

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/Swiss-Prot
      F1LP64, F1LP79, Q497C1, Q5I0I0
      UniProtKB/TrEMBL
      A6JWC9
      Related
      ENSRNOP00000108120.1, ENSRNOT00000151192.1
      Conserved Domains (4) summary
      COG5064
      Location:447672
      SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
      cd00078
      Location:16232023
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam02825
      Location:767831
      WWE; WWE domain
      pfam03546
      Location:99377
      Treacle; Treacher Collins syndrome protein Treacle

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      93364791..93491015 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063267250.1XP_063123320.1  E3 ubiquitin-protein ligase TRIP12 isoform X3

      UniProtKB/TrEMBL
      A0A0G2JU73, A0A8I6AHN4
    2. XM_063267247.1XP_063123317.1  E3 ubiquitin-protein ligase TRIP12 isoform X2

      UniProtKB/TrEMBL
      A0A0G2JU73
    3. XM_063267240.1XP_063123310.1  E3 ubiquitin-protein ligase TRIP12 isoform X1

      UniProtKB/TrEMBL
      A0A0G2JU73
    4. XM_063267279.1XP_063123349.1  E3 ubiquitin-protein ligase TRIP12 isoform X23

      UniProtKB/TrEMBL
      A0A0G2JU73
    5. XM_063267267.1XP_063123337.1  E3 ubiquitin-protein ligase TRIP12 isoform X16

      UniProtKB/TrEMBL
      A0A8L2RBG4, A6JWC9
    6. XM_063267280.1XP_063123350.1  E3 ubiquitin-protein ligase TRIP12 isoform X25

      UniProtKB/TrEMBL
      A0A0G2JU73
    7. XM_063267278.1XP_063123348.1  E3 ubiquitin-protein ligase TRIP12 isoform X23

      UniProtKB/TrEMBL
      A0A0G2JU73
    8. XM_063267276.1XP_063123346.1  E3 ubiquitin-protein ligase TRIP12 isoform X22

      UniProtKB/TrEMBL
      A0A0G2JU73
    9. XM_039083712.2XP_038939640.1  E3 ubiquitin-protein ligase TRIP12 isoform X26

      UniProtKB/TrEMBL
      A6JWC9
      Conserved Domains (4) summary
      COG5064
      Location:447672
      SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
      cd00078
      Location:15911991
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam02825
      Location:769803
      WWE; WWE domain
      pfam15229
      Location:11150
      POM121; POM121 family
    10. XM_017596488.3XP_017451977.1  E3 ubiquitin-protein ligase TRIP12 isoform X24

      UniProtKB/TrEMBL
      A6JWC9
    11. XM_063267274.1XP_063123344.1  E3 ubiquitin-protein ligase TRIP12 isoform X21

      UniProtKB/TrEMBL
      A6JWC9
    12. XM_039083711.2XP_038939639.1  E3 ubiquitin-protein ligase TRIP12 isoform X20

      UniProtKB/TrEMBL
      A6JWC9
      Conserved Domains (4) summary
      COG5064
      Location:447672
      SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
      cd00078
      Location:16182018
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam02825
      Location:769830
      WWE; WWE domain
      pfam15229
      Location:11150
      POM121; POM121 family
    13. XM_063267266.1XP_063123336.1  E3 ubiquitin-protein ligase TRIP12 isoform X16

      UniProtKB/TrEMBL
      A0A8L2RBG4, A6JWC9
      Related
      ENSRNOP00000076130.2, ENSRNOT00000093245.3
    14. XM_063267273.1XP_063123343.1  E3 ubiquitin-protein ligase TRIP12 isoform X19

      UniProtKB/TrEMBL
      A6JWC9
    15. XM_063267269.1XP_063123339.1  E3 ubiquitin-protein ligase TRIP12 isoform X17

      UniProtKB/TrEMBL
      A6JWC9
    16. XM_063267262.1XP_063123332.1  E3 ubiquitin-protein ligase TRIP12 isoform X15

      UniProtKB/TrEMBL
      A6JWC9
    17. XM_039083709.2XP_038939637.1  E3 ubiquitin-protein ligase TRIP12 isoform X14

      UniProtKB/TrEMBL
      A0A0G2JU73
      Conserved Domains (3) summary
      COG5064
      Location:460685
      SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
      cd00078
      Location:16312031
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam02825
      Location:782843
      WWE; WWE domain
    18. XM_063267258.1XP_063123328.1  E3 ubiquitin-protein ligase TRIP12 isoform X11

      UniProtKB/TrEMBL
      A0A0G2JU73
      Related
      ENSRNOP00000068991.3, ENSRNOT00000079452.3
    19. XM_063267257.1XP_063123327.1  E3 ubiquitin-protein ligase TRIP12 isoform X9

      UniProtKB/TrEMBL
      A0A0G2JU73
    20. XM_063267261.1XP_063123331.1  E3 ubiquitin-protein ligase TRIP12 isoform X13

      UniProtKB/TrEMBL
      A0A0G2JU73
    21. XM_063267259.1XP_063123329.1  E3 ubiquitin-protein ligase TRIP12 isoform X12

      UniProtKB/TrEMBL
      A0A0G2JU73
    22. XM_017596487.3XP_017451976.1  E3 ubiquitin-protein ligase TRIP12 isoform X10

      UniProtKB/TrEMBL
      A0A0G2JU73
    23. XM_063267256.1XP_063123326.1  E3 ubiquitin-protein ligase TRIP12 isoform X8

      UniProtKB/TrEMBL
      A0A0G2JU73
    24. XM_039083703.2XP_038939631.1  E3 ubiquitin-protein ligase TRIP12 isoform X7

      UniProtKB/TrEMBL
      A0A0G2JU73
      Conserved Domains (3) summary
      COG5064
      Location:489714
      SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
      cd00078
      Location:16602060
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam02825
      Location:811872
      WWE; WWE domain
    25. XM_063267253.1XP_063123323.1  E3 ubiquitin-protein ligase TRIP12 isoform X5

      UniProtKB/TrEMBL
      A0A0G2JU73
    26. XM_006245379.5XP_006245441.1  E3 ubiquitin-protein ligase TRIP12 isoform X3

      UniProtKB/TrEMBL
      A0A0G2JU73, A0A8I6AHN4
      Related
      ENSRNOP00000092462.1, ENSRNOT00000107698.2
      Conserved Domains (3) summary
      smart00119
      Location:16832061
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      cd00078
      Location:16652065
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam02825
      Location:808873
      WWE; WWE domain
    27. XM_063267243.1XP_063123313.1  E3 ubiquitin-protein ligase TRIP12 isoform X2

      UniProtKB/TrEMBL
      A0A0G2JU73
    28. XM_006245380.5XP_006245442.1  E3 ubiquitin-protein ligase TRIP12 isoform X6

      UniProtKB/TrEMBL
      A0A0G2JU73
      Conserved Domains (3) summary
      smart00119
      Location:16792057
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      cd00078
      Location:16612061
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam02825
      Location:808874
      WWE; WWE domain
    29. XM_063267251.1XP_063123321.1  E3 ubiquitin-protein ligase TRIP12 isoform X4

      UniProtKB/TrEMBL
      A0A0G2JU73
    30. XM_008767252.4XP_008765474.1  E3 ubiquitin-protein ligase TRIP12 isoform X1

      See identical proteins and their annotated locations for XP_008765474.1

      UniProtKB/TrEMBL
      A0A0G2JU73
      Conserved Domains (3) summary
      smart00119
      Location:16872065
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      cd00078
      Location:16692069
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam02825
      Location:808874
      WWE; WWE domain
    31. XM_063267268.1XP_063123338.1  E3 ubiquitin-protein ligase TRIP12 isoform X16

      UniProtKB/TrEMBL
      A0A8L2RBG4, A6JWC9
    32. XM_063267241.1XP_063123311.1  E3 ubiquitin-protein ligase TRIP12 isoform X1

      UniProtKB/TrEMBL
      A0A0G2JU73
    33. XM_063267272.1XP_063123342.1  E3 ubiquitin-protein ligase TRIP12 isoform X18

      UniProtKB/Swiss-Prot
      F1LP64, F1LP79, Q497C1, Q5I0I0
      UniProtKB/TrEMBL
      A6JWC9
    34. XM_063267264.1XP_063123334.1  E3 ubiquitin-protein ligase TRIP12 isoform X15

      UniProtKB/TrEMBL
      A6JWC9
    35. XM_063267254.1XP_063123324.1  E3 ubiquitin-protein ligase TRIP12 isoform X7

      UniProtKB/TrEMBL
      A0A0G2JU73
      Related
      ENSRNOP00000104101.1, ENSRNOT00000163092.1
    36. XM_063267249.1XP_063123319.1  E3 ubiquitin-protein ligase TRIP12 isoform X3

      UniProtKB/TrEMBL
      A0A0G2JU73, A0A8I6AHN4
    37. XM_063267246.1XP_063123316.1  E3 ubiquitin-protein ligase TRIP12 isoform X2

      UniProtKB/TrEMBL
      A0A0G2JU73
    38. XM_063267275.1XP_063123345.1  E3 ubiquitin-protein ligase TRIP12 isoform X21

      UniProtKB/TrEMBL
      A6JWC9
    39. XM_063267277.1XP_063123347.1  E3 ubiquitin-protein ligase TRIP12 isoform X22

      UniProtKB/TrEMBL
      A0A0G2JU73
    40. XM_063267271.1XP_063123341.1  E3 ubiquitin-protein ligase TRIP12 isoform X18

      UniProtKB/Swiss-Prot
      F1LP64, F1LP79, Q497C1, Q5I0I0
      UniProtKB/TrEMBL
      A6JWC9
    41. XM_063267265.1XP_063123335.1  E3 ubiquitin-protein ligase TRIP12 isoform X16

      UniProtKB/TrEMBL
      A0A8L2RBG4, A6JWC9
    42. XM_063267270.1XP_063123340.1  E3 ubiquitin-protein ligase TRIP12 isoform X17

      UniProtKB/TrEMBL
      A6JWC9
    43. XM_063267263.1XP_063123333.1  E3 ubiquitin-protein ligase TRIP12 isoform X15

      UniProtKB/TrEMBL
      A6JWC9
    44. XM_063267255.1XP_063123325.1  E3 ubiquitin-protein ligase TRIP12 isoform X7

      UniProtKB/TrEMBL
      A0A0G2JU73
    45. XM_063267248.1XP_063123318.1  E3 ubiquitin-protein ligase TRIP12 isoform X3

      UniProtKB/TrEMBL
      A0A0G2JU73, A0A8I6AHN4
    46. XM_063267244.1XP_063123314.1  E3 ubiquitin-protein ligase TRIP12 isoform X2

      UniProtKB/TrEMBL
      A0A0G2JU73
    47. XM_063267238.1XP_063123308.1  E3 ubiquitin-protein ligase TRIP12 isoform X1

      UniProtKB/TrEMBL
      A0A0G2JU73
    48. XM_063267245.1XP_063123315.1  E3 ubiquitin-protein ligase TRIP12 isoform X2

      UniProtKB/TrEMBL
      A0A0G2JU73
    49. XM_063267239.1XP_063123309.1  E3 ubiquitin-protein ligase TRIP12 isoform X1

      UniProtKB/TrEMBL
      A0A0G2JU73