Fabp5 fatty acid binding protein 5 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Fabp5provided by RGD
Official Full Name: fatty acid binding protein 5provided by RGD
Primary source: RGD:70997
See related: EnsemblRapid:ENSRNOG00000049075 AllianceGenome:RGD:70997
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: DA11; C-FABP; E-FABP
Summary: Enables fatty acid binding activity. Predicted to be involved in several processes, including lipid transport across blood-brain barrier; positive regulation of cold-induced thermogenesis; and positive regulation of peroxisome proliferator activated receptor signaling pathway. Predicted to act upstream of or within several processes, including glucose homeostasis; negative regulation of D-glucose transmembrane transport; and phosphatidylcholine biosynthetic process. Predicted to be located in cytoplasm; extracellular space; and postsynaptic density. Predicted to be active in several cellular components, including glutamatergic synapse; postsynaptic cytosol; and postsynaptic density, intracellular component. Orthologous to several human genes including FABP5 (fatty acid binding protein 5). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Lung (RPKM 221.3), Liver (RPKM 161.3) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 2q23

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (93672451..93676186, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (91765056..91768716, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (93981662..93985322, complement)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Fatty acid binding protein 5 inhibition attenuates pronociceptive cytokine/chemokine expression and suppresses osteoarthritis pain: A comparative human and rat study.
Title: Fatty acid binding protein 5 inhibition attenuates pronociceptive cytokine/chemokine expression and suppresses osteoarthritis pain: A comparative human and rat study.
Inhibition of fatty acid binding protein-5 in the basolateral amygdala induces anxiolytic effects and accelerates fear memory extinction.
Title: Inhibition of fatty acid binding protein-5 in the basolateral amygdala induces anxiolytic effects and accelerates fear memory extinction.
Identification of a novel fatty acid binding protein-5-CB2 receptor-dependent mechanism regulating anxiety behaviors in the prefrontal cortex.
Title: Identification of a novel fatty acid binding protein-5-CB2 receptor-dependent mechanism regulating anxiety behaviors in the prefrontal cortex.
FABP5 promotes the budding of particles approximately 150 nm in diameter and modulates the kinetics of the SAR1 GTPase cycle.
Title: Fatty-acid binding protein 5 modulates the SAR1 GTPase cycle and enhances budding of large COPII cargoes.
A complex interrelationship between glucose and fatty acids in the control of FABP gene expression; FABP3 and 5 may play a role in insulin secretion.
Title: Expression of fatty acid binding proteins 3 and 5 genes in rat pancreatic islets and INS-1E cells: regulation by fatty acids and glucose.
FABP5 is upregulated in alveolar macrophages during severe inflammation.
Title: Increased expression of epidermal fatty acid-binding protein by alveolar macrophages during acute rejection of rat lungs.
We postulate that a differential regulation of proteasomal function, as demonstrated for TGF-beta 1, can result in an enrichment of proteins, such as EFABP, that mediate physiological functions, such as neurite regeneration.
Title: TGF-beta 1 enhances neurite outgrowth via regulation of proteasome function and EFABP.
These findings are consistent with the scenario that neurite extension of differentiating PC12 cells, including further stimulation by DHA and EPA, requires sufficient cellular levels of E-FABP.
Title: Expression of E-FABP in PC12 cells increases neurite extension during differentiation: involvement of n-3 and n-6 fatty acids.
C-FABP may play a significant role in regulating adipocyte function in response to changes in nutritional conditions.
Title: Modulation of cutaneous fatty acid-binding protein mRNA expression in rat adipose tissues by hereditary obesity and dietary fats.
epithelial fatty acid-binding protein (Fabp5, E_FABP)participates in leukotriene biosynthesis that permits of leukotriene A4 to be available for further enzymatic processing in various cellular regions.
Title: Stabilization of leukotriene A4 by epithelial fatty acid-binding protein in the rat basophilic leukemia cell.

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables fatty acid binding	IBA Inferred from Biological aspect of Ancestor more info
enables fatty acid binding	IDA Inferred from Direct Assay more info	PubMed
enables fatty acid binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables lipid binding	IEA Inferred from Electronic Annotation more info
enables long-chain fatty acid transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables retinoic acid binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in fatty acid transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within glucose homeostasis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within glucose metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within lipid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in lipid transport	IEA Inferred from Electronic Annotation more info
involved_in lipid transport across blood-brain barrier	ISO Inferred from Sequence Orthology more info
involved_in long-chain fatty acid transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of D-glucose transmembrane transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within phosphatidylcholine biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cold-induced thermogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cold-induced thermogenesis	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in positive regulation of peroxisome proliferator activated receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in regulation of prostaglandin biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of retrograde trans-synaptic signaling by endocanabinoid	ISO Inferred from Sequence Orthology more info
involved_in regulation of retrograde trans-synaptic signaling by endocanabinoid	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of sensory perception of pain	ISO Inferred from Sequence Orthology more info
involved_in retrograde trans-synaptic signaling by endocannabinoid	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in extracellular space	ISS Inferred from Sequence or Structural Similarity more info
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
is_active_in postsynaptic cytosol	ISO Inferred from Sequence Orthology more info
located_in postsynaptic density	IEA Inferred from Electronic Annotation more info
located_in postsynaptic density	ISO Inferred from Sequence Orthology more info
located_in postsynaptic density	ISS Inferred from Sequence or Structural Similarity more info
is_active_in postsynaptic density, intracellular component	ISO Inferred from Sequence Orthology more info
located_in synapse	ISO Inferred from Sequence Orthology more info
located_in synapse	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: fatty acid-binding protein 5

Names: cutaneous fatty acid-binding protein; epidermal-type fatty acid-binding protein; fatty acid binding protein 5, epidermal; fatty acid-binding protein, epidermal

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_145878.2 → NP_665885.2 fatty acid-binding protein 5

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000002

UniProtKB/Swiss-Prot

P55053, P97757

UniProtKB/TrEMBL

A6IH50

Related

ENSRNOP00000064809.3, ENSRNOT00000075493.4

Conserved Domains (1) summary

cd19468
Location:6 → 133

FABP5; fatty acid binding protein 5