U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Usp26 ubiquitin specific peptidase 26 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 302488, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Symbol
    Usp26provided by RGD
    Full Name
    ubiquitin specific peptidase 26provided by RGD
    Primary source
    RGD:1563443
    See related
    EnsemblRapid:ENSRNOG00000029106 AllianceGenome:RGD:1563443
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1563443
    Summary
    Predicted to enable K48-linked deubiquitinase activity and cysteine-type deubiquitinase activity. Predicted to be involved in several processes, including G1/S transition of mitotic cell cycle; negative regulation of proteasomal ubiquitin-dependent protein catabolic process; and regulation of androgen receptor signaling pathway. Predicted to be located in nucleoplasm and sperm flagellum. Predicted to be active in cytosol and nucleus. Human ortholog(s) of this gene implicated in X-linked spermatogenic failure 6. Orthologous to human USP26 (ubiquitin specific peptidase 26). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Testes (RPKM 92.1) and Kidney (RPKM 26.0) See more
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Usp26 in Genome Data Viewer
    Location:
    Xq36
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (136237504..136284646, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (131317200..131363964, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (139030239..139079336, complement)

    Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene high mobility group protein B4-like Neighboring gene heparan sulfate 6-O-sulfotransferase 2 Neighboring gene mitochondrial ribosomal protein L30, pseudogene 3 Neighboring gene coiled-coil-helix-coiled-coil-helix domain containing 3, pseudogene 1 Neighboring gene uncharacterized LOC102550607 Neighboring gene MAGE family member A14 Neighboring gene high mobility group protein B4-like

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. The deubiquitinating enzyme USP26 is a regulator of androgen receptor signaling. Dirac AM, et al. Mol Cancer Res, 2010 Jun. PMID 20501646
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables K48-linked deubiquitinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables cysteine-type deubiquitinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables deubiquitinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in G1/S transition of mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of proteasomal ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein deubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of androgen receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of protein stability IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in spermatogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in sperm flagellum ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    ubiquitin carboxyl-terminal hydrolase 26
    NP_001100418.1
    XP_038955531.1
    XP_038955533.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106948.1 → NP_001100418.1  ubiquitin carboxyl-terminal hydrolase 26

      See identical proteins and their annotated locations for NP_001100418.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473991
      UniProtKB/TrEMBL
      A6JMT7, D4A5S1
      Related
      ENSRNOP00000047375.3, ENSRNOT00000047605.7
      Conserved Domains (4) summary
      COG5077
      Location:181 → 378
      COG5077; Ubiquitin carboxyl-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]
      cl02553
      Location:740 → 805
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
      pfam00443
      Location:288 → 557
      UCH; Ubiquitin carboxyl-terminal hydrolase
      pfam16674
      Location:3 → 103
      UCH_N; N-terminal of ubiquitin carboxyl-terminal hydrolase 37

    2. NM_001433989.1 → NP_001420918.1  ubiquitin carboxyl-terminal hydrolase 26

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000021
      UniProtKB/TrEMBL
      A6JMT7, D4A5S1

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086039.1 Reference GRCr8

      Range
      136237504..136284646 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039099603.2 → XP_038955531.1  ubiquitin carboxyl-terminal hydrolase 26 isoform X1

      Related
      ENSRNOP00000085992.1, ENSRNOT00000116818.2
      Conserved Domains (4) summary
      COG5077
      Location:181 → 378
      COG5077; Ubiquitin carboxyl-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]
      cl02553
      Location:740 → 805
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
      pfam00443
      Location:288 → 557
      UCH; Ubiquitin carboxyl-terminal hydrolase
      pfam16674
      Location:3 → 103
      UCH_N; N-terminal of ubiquitin carboxyl-terminal hydrolase 37

    2. XM_039099605.2 → XP_038955533.1  ubiquitin carboxyl-terminal hydrolase 26 isoform X1

      UniProtKB/TrEMBL
      A6JMT7, D4A5S1
      Conserved Domains (4) summary
      COG5077
      Location:181 → 378
      COG5077; Ubiquitin carboxyl-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]
      cl02553
      Location:740 → 805
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
      pfam00443
      Location:288 → 557
      UCH; Ubiquitin carboxyl-terminal hydrolase
      pfam16674
      Location:3 → 103
      UCH_N; N-terminal of ubiquitin carboxyl-terminal hydrolase 37
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous