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    Pgap4 post-GPI attachment to proteins GalNAc transferase 4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 362518, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Pgap4provided by RGD
    Official Full Name
    post-GPI attachment to proteins GalNAc transferase 4provided by RGD
    Primary source
    RGD:1307218
    See related
    EnsemblRapid:ENSRNOG00000006800 AllianceGenome:RGD:1307218
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Tmem246; RGD1307218
    Summary
    Predicted to enable glycosyltransferase activity. Predicted to be involved in GPI anchor biosynthetic process. Predicted to be active in Golgi membrane. Orthologous to human PGAP4 (post-GPI attachment to proteins GalNAc transferase 4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 40.6), Heart (RPKM 38.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Pgap4 in Genome Data Viewer
    Location:
    5q22
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (68727422..68742571, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (63931916..63947004, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (64848657..64867925, complement)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134478967 Neighboring gene aldolase, fructose-bisphosphate B Neighboring gene ring finger protein 20 Neighboring gene glutamate ionotropic receptor NMDA type subunit 3A Neighboring gene protein phosphatase 3, regulatory subunit B, beta

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Identification of a Golgi GPI-N-acetylgalactosamine transferase with tandem transmembrane regions in the catalytic domain. Hirata T, et al. Nat Commun, 2018 Jan 26. PMID 29374258, Free PMC Article
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC109354

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables glycosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glycosyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables glycosyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in GPI anchor biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in GPI anchor biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in GPI anchor biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in Golgi membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    post-GPI attachment to proteins factor 4
    Names
    transmembrane protein 246
    transmembrane protein C9orf125 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001014190.1 → NP_001014212.1  post-GPI attachment to proteins factor 4

      See identical proteins and their annotated locations for NP_001014212.1

      Status: PROVISIONAL

      Source sequence(s)
      BC089972
      UniProtKB/Swiss-Prot
      Q5EB73
      UniProtKB/TrEMBL
      A6KJD7
      Conserved Domains (1) summary
      cd22190
      Location:25 → 395
      PGAP4; Post-GPI attachment to proteins factor 4

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      68727422..68742571 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006238158.5 → XP_006238220.1  post-GPI attachment to proteins factor 4 isoform X1

      See identical proteins and their annotated locations for XP_006238220.1

      UniProtKB/Swiss-Prot
      Q5EB73
      UniProtKB/TrEMBL
      A6KJD7
      Related
      ENSRNOP00000008883.5, ENSRNOT00000008883.9
      Conserved Domains (1) summary
      cd22190
      Location:25 → 395
      PGAP4; Post-GPI attachment to proteins factor 4

    2. XM_006238159.5 → XP_006238221.1  post-GPI attachment to proteins factor 4 isoform X1

      See identical proteins and their annotated locations for XP_006238221.1

      UniProtKB/Swiss-Prot
      Q5EB73
      UniProtKB/TrEMBL
      A6KJD7
      Related
      ENSRNOP00000097268.1, ENSRNOT00000104584.2
      Conserved Domains (1) summary
      cd22190
      Location:25 → 395
      PGAP4; Post-GPI attachment to proteins factor 4

    3. XM_017593473.3 → XP_017448962.1  post-GPI attachment to proteins factor 4 isoform X1

      UniProtKB/Swiss-Prot
      Q5EB73
      UniProtKB/TrEMBL
      A6KJD7
      Conserved Domains (1) summary
      cd22190
      Location:25 → 395
      PGAP4; Post-GPI attachment to proteins factor 4

    4. XM_017593474.3 → XP_017448963.1  post-GPI attachment to proteins factor 4 isoform X1

      UniProtKB/Swiss-Prot
      Q5EB73
      UniProtKB/TrEMBL
      A6KJD7
      Conserved Domains (1) summary
      cd22190
      Location:25 → 395
      PGAP4; Post-GPI attachment to proteins factor 4
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5EB73.1 GenPept UniProtKB/Swiss-Prot:Q5EB73

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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