Pth2 parathyroid hormone 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Pth2provided by RGD
Official Full Name: parathyroid hormone 2provided by RGD
Primary source: RGD:1559447
See related: EnsemblRapid:ENSRNOG00000072882 AllianceGenome:RGD:1559447
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Tip39; Tifp39; RGD1559447
Summary: Predicted to be involved in neuropeptide signaling pathway. Predicted to be located in extracellular region. Orthologous to human PTH2 (parathyroid hormone 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Testes (RPKM 2.5), Muscle (RPKM 1.0) and 5 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q22

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (104802983..104803632)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (95666525..95667174)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (101175499..101179001)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

TIP39 neurons in the PIL may regulate suckling-induced prolactin release in rat dams.
Title: Tuberoinfundibular peptide of 39 residues is activated during lactation and participates in the suckling-induced prolactin release in rat.
TIP39 neurons are sensitive to loud noise and they may participate in the central organization of responses to acoustic stress; non-TIP39-expressing neurons may play a prevalent role in the activity of the "acoustic thalamus"
Title: Acoustic stress activates tuberoinfundibular peptide of 39 residues neurons in the rat brain.
The complex pattern of TIP39 expression during early brain development suggests the involvement of TIP39 in transient functions during ontogeny.
Title: Tuberoinfundibular peptide of 39 residues in the embryonic and early postnatal rat brain.
Our data provide an anatomical basis for the potential involvement of rostral subparafascicular neurons in limbic and autonomic regulation, with TIP39 cells being major subparafascicular output neurons projecting to forebrain regions.
Title: Forebrain projections of tuberoinfundibular peptide of 39 residues (TIP39)-containing subparafascicular neurons.
results suggest that an inhibition of endogenous nitric oxide production unmasks a profound negative inotropic effect of tuberoinfundibular peptide (TIP39) that is mediated by an activation of the parathyroid hormone receptor 2 receptor
Title: Tuberoinfundibular peptide of 39 residues: a new mediator of cardiac function via nitric oxide production in the rat heart.
TIP39-containing neurons project to a number of limbic areas implicating them in limbic and endocrine functions; those that project to the medial paralemniscal nucleus may participate in auditory and nociceptive functions.
Title: Neurons containing tuberoinfundibular peptide of 39 residues project to limbic, endocrine, auditory and spinal areas in rat.

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General gene information

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Gene Ontology Provided by RGD

Process	Evidence Code	Pubs
involved_in neuropeptide signaling pathway	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: tuberoinfundibular peptide of 39 residues

Names: tuberoinfundibular peptide of 39 amino acids; tuberoinfundibular peptide of 39 residues (TIP39) preprohormone

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.