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    Gzf1 GDNF-inducible zinc finger protein 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 311508, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Gzf1provided by RGD
    Official Full Name
    GDNF-inducible zinc finger protein 1provided by RGD
    Primary source
    RGD:1562321
    See related
    EnsemblRapid:ENSRNOG00000004735 AllianceGenome:RGD:1562321
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Zfp336; RGD1562321
    Summary
    Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of DNA-templated transcription. Predicted to act upstream of or within branching involved in ureteric bud morphogenesis and negative regulation of transcription by RNA polymerase II. Predicted to be located in nucleolus and nucleoplasm. Orthologous to human GZF1 (GDNF inducible zinc finger protein 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 77.4), Kidney (RPKM 67.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Gzf1 in Genome Data Viewer
    Location:
    3q41
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (156572152..156584369)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (136119004..136131223)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (143003706..143015906)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene nuclear transport factor 2-like export factor 1 Neighboring gene Sertoli cell protein 1 Neighboring gene NSF attachment protein beta Neighboring gene cystatin-like 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. GDNF-inducible zinc finger protein 1 is a sequence-specific transcriptional repressor that binds to the HOXA10 gene regulatory region. Morinaga T, et al. Nucleic Acids Res, 2005. PMID 16049025, Free PMC Article
    2. Identification of a novel glial cell line-derived neurotrophic factor-inducible gene required for renal branching morphogenesis. Fukuda N, et al. J Biol Chem, 2003 Dec 12. PMID 14522971
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables sequence-specific DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within branching involved in ureteric bud morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of DNA-templated transcription ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    GDNF-inducible zinc finger protein 1
    Names
    zinc finger protein 336

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107788.2 → NP_001101258.1  GDNF-inducible zinc finger protein 1

      See identical proteins and their annotated locations for NP_001101258.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/Swiss-Prot
      D3ZUU2
      UniProtKB/TrEMBL
      A0A8I6ARB4
      Conserved Domains (6) summary
      smart00225
      Location:32 → 125
      BTB; Broad-Complex, Tramtrack and Bric a brac
      COG5048
      Location:411 → 539
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:520 → 540
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:318 → 338
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00651
      Location:21 → 125
      BTB; BTB/POZ domain
      pfam13465
      Location:532 → 557
      zf-H2C2_2; Zinc-finger double domain

    2. NM_001434038.1 → NP_001420967.1  GDNF-inducible zinc finger protein 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/Swiss-Prot
      D3ZUU2
      UniProtKB/TrEMBL
      A0A8I6ARB4

    3. NM_001434039.1 → NP_001420968.1  GDNF-inducible zinc finger protein 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/Swiss-Prot
      D3ZUU2
      UniProtKB/TrEMBL
      A0A8I6ARB4

    RNA

    1. NR_197759.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003

    2. NR_197760.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      156572152..156584369
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006235153.5 → XP_006235215.1  GDNF-inducible zinc finger protein 1 isoform X1

      Conserved Domains (6) summary
      smart00225
      Location:32 → 125
      BTB; Broad-Complex, Tramtrack and Bric a brac
      COG5048
      Location:411 → 539
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:520 → 540
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:318 → 338
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00651
      Location:21 → 125
      BTB; BTB/POZ domain
      pfam13465
      Location:532 → 557
      zf-H2C2_2; Zinc-finger double domain

    2. XM_039105049.2 → XP_038960977.1  GDNF-inducible zinc finger protein 1 isoform X2

      Conserved Domains (2) summary
      sd00017
      Location:349 → 370
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cl38908
      Location:6 → 133
      BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily

    3. XM_063283812.1 → XP_063139882.1  GDNF-inducible zinc finger protein 1 isoform X3

    4. XM_008762274.4 → XP_008760496.1  GDNF-inducible zinc finger protein 1 isoform X1

      Related
      ENSRNOP00000006287.3, ENSRNOT00000006287.5
      Conserved Domains (6) summary
      smart00225
      Location:32 → 125
      BTB; Broad-Complex, Tramtrack and Bric a brac
      COG5048
      Location:411 → 539
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:520 → 540
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:318 → 338
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00651
      Location:21 → 125
      BTB; BTB/POZ domain
      pfam13465
      Location:532 → 557
      zf-H2C2_2; Zinc-finger double domain

    5. XM_063283811.1 → XP_063139881.1  GDNF-inducible zinc finger protein 1 isoform X1

      UniProtKB/Swiss-Prot
      D3ZUU2
      UniProtKB/TrEMBL
      A0A8I6ARB4
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    D3ZUU2.1 GenPept UniProtKB/Swiss-Prot:D3ZUU2

    Gene LinkOut

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