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    Ube2b ubiquitin-conjugating enzyme E2B [ Rattus norvegicus (Norway rat) ]

    Gene ID: 81816, updated on 9-Dec-2024

    Summary

    Symbol
    Ube2bprovided by RGD
    Full Name
    ubiquitin-conjugating enzyme E2Bprovided by RGD
    Primary source
    RGD:708345
    See related
    EnsemblRapid:ENSRNOG00000059348 AllianceGenome:RGD:708345
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    HR6B
    Summary
    Predicted to enable ubiquitin conjugating enzyme activity and ubiquitin protein ligase binding activity. Involved in cellular response to insulin stimulus; response to hypoxia; and ubiquitin-dependent protein catabolic process. Predicted to be located in chromosome; cytoplasm; and nucleus. Predicted to be part of HULC complex. Orthologous to human UBE2B (ubiquitin conjugating enzyme E2 B). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Muscle (RPKM 760.8), Heart (RPKM 484.7) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Ube2b in Genome Data Viewer
    Location:
    10q22
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (36749365..36764335, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (36248434..36263379, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (37439947..37454867, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA70 Neighboring gene CDKN2A interacting protein N-terminal like Neighboring gene cyclin-dependent kinase-like 3 Neighboring gene large ribosomal subunit protein eL21-like Neighboring gene protein phosphatase 2 catalytic subunit alpha

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding  
    enables transferase activity  
    enables ubiquitin conjugating enzyme activity  
    enables ubiquitin conjugating enzyme activity  
    enables ubiquitin conjugating enzyme activity  
    enables ubiquitin protein ligase binding  
    enables ubiquitin protein ligase binding  
    enables ubiquitin-protein transferase activity  
    enables ubiquitin-protein transferase activity  
    Items 1 - 25 of 46
    Process Evidence Code Pubs
    involved_in DNA damage response  
    involved_in DNA repair  
    involved_in DNA repair  
    involved_in DNA repair  
    acts_upstream_of apoptotic process  
    involved_in cellular response to insulin stimulus PubMed 
    acts_upstream_of_or_within chiasma assembly  
    acts_upstream_of_or_within chromatin organization  
    acts_upstream_of ectopic germ cell programmed cell death  
    acts_upstream_of_or_within in utero embryonic development  
    acts_upstream_of_or_within meiotic telomere clustering  
    acts_upstream_of_or_within negative regulation of apoptotic process  
    acts_upstream_of_or_within negative regulation of developmental process  
    acts_upstream_of_or_within negative regulation of post-translational protein modification  
    acts_upstream_of_or_within negative regulation of reproductive process  
    involved_in positive regulation of canonical Wnt signaling pathway  
    acts_upstream_of_or_within positive regulation of reciprocal meiotic recombination  
    involved_in postreplication repair  
    involved_in postreplication repair  
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process  
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process  
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process  
    involved_in protein K11-linked ubiquitination  
    involved_in protein K11-linked ubiquitination  
    involved_in protein K11-linked ubiquitination  
    involved_in protein K48-linked ubiquitination  
    involved_in protein K48-linked ubiquitination  
    involved_in protein K48-linked ubiquitination  
    involved_in protein K63-linked ubiquitination  
    involved_in protein K63-linked ubiquitination  
    involved_in protein K63-linked ubiquitination  
    involved_in protein autoubiquitination  
    involved_in protein autoubiquitination  
    involved_in protein polyubiquitination  
    involved_in protein stabilization  
    involved_in protein stabilization  
    involved_in protein ubiquitination  
    involved_in response to UV  
    involved_in response to UV  
    involved_in response to hypoxia PubMed 
    involved_in response to xenobiotic stimulus  
    involved_in response to xenobiotic stimulus  
    acts_upstream_of_or_within sperm axoneme assembly  
    acts_upstream_of_or_within synaptonemal complex organization  
    involved_in ubiquitin-dependent protein catabolic process PubMed 
    involved_in ubiquitin-dependent protein catabolic process  
    Items 1 - 25 of 46
    Component Evidence Code Pubs
    part_of HULC complex  
    part_of HULC complex  
    part_of HULC complex  
    part_of HULC complex  
    located_in XY body  
    located_in chromatin  
    located_in cytoplasm  
    located_in cytoplasm  
    located_in nucleus  
    located_in nucleus  
    located_in plasma membrane  
    located_in replication fork  
    located_in replication fork  

    General protein information

    Preferred Names
    ubiquitin-conjugating enzyme E2 B
    Names
    E2 ubiquitin-conjugating enzyme B
    E2(14k)
    RAD6 homolog B
    ubiquitin carrier protein B
    ubiquitin conjugating enzyme
    ubiquitin-conjugating enzyme E2(14k)
    ubiquitin-conjugating enzyme E2B (RAD6 homolog, S. cerevisiae)
    ubiquitin-conjugating enzyme E2B, RAD6 homolog
    ubiquitin-conjugating enzyme E2B, RAD6 homology
    ubiquitin-protein ligase B
    NP_112400.1
    XP_006246405.1
    XP_038942869.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_031138.2NP_112400.1  ubiquitin-conjugating enzyme E2 B

      See identical proteins and their annotated locations for NP_112400.1

      Status: VALIDATED

      Source sequence(s)
      BC070946, BE111816, DN931313
      UniProtKB/Swiss-Prot
      P63149
      UniProtKB/TrEMBL
      A0A0G2JYU5, A6HE85
      Related
      ENSRNOP00000070793.2, ENSRNOT00000091694.3
      Conserved Domains (1) summary
      pfam00179
      Location:8145
      UQ_con; Ubiquitin-conjugating enzyme

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      36749365..36764335 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006246343.4XP_006246405.1  ubiquitin-conjugating enzyme E2 B isoform X1

      See identical proteins and their annotated locations for XP_006246405.1

      UniProtKB/TrEMBL
      A0A8I6ANY2, A6HE84
      Related
      ENSRNOP00000095094.1, ENSRNOT00000106084.2
      Conserved Domains (1) summary
      pfam00179
      Location:36173
      UQ_con; Ubiquitin-conjugating enzyme
    2. XM_039086941.2XP_038942869.1  ubiquitin-conjugating enzyme E2 B isoform X2

      Conserved Domains (1) summary
      pfam00179
      Location:36143
      UQ_con; Ubiquitin-conjugating enzyme
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