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    Fam83d family with sequence similarity 83, member D [ Rattus norvegicus (Norway rat) ]

    Gene ID: 311598, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Fam83dprovided by RGD
    Official Full Name
    family with sequence similarity 83, member Dprovided by RGD
    Primary source
    RGD:1565583
    See related
    EnsemblRapid:ENSRNOG00000015794 AllianceGenome:RGD:1565583
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1565583
    Summary
    Predicted to enable kinesin binding activity; microtubule binding activity; and protein kinase binding activity. Predicted to be involved in several processes, including positive regulation of cell cycle G1/S phase transition; protein localization to mitotic spindle; and regulation of intracellular signal transduction. Predicted to be located in cytoplasm; intercellular bridge; and mitotic spindle. Predicted to be active in cytosol and mitotic spindle pole. Orthologous to human FAM83D (family with sequence similarity 83 member D). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Lung (RPKM 37.1), Thymus (RPKM 32.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Fam83d in Genome Data Viewer
    Location:
    3q42
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (167841748..167861062)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (147421941..147441211)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (155269344..155288612)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene actin related protein 5 Neighboring gene protein phosphatase 1, regulatory subunit 16B Neighboring gene 60S ribosomal protein L13-like Neighboring gene DEAH-box helicase 35 Neighboring gene uncharacterized LOC134486305

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. FAM83D activates the MEK/ERK signaling pathway and promotes cell proliferation in hepatocellular carcinoma. Wang D, et al. Biochem Biophys Res Commun, 2015 Mar 6. PMID 25646692
    2. FAM83D promotes cell proliferation and motility by downregulating tumor suppressor gene FBXW7. Wang Z, et al. Oncotarget, 2013 Dec. PMID 24344117, Free PMC Article
    3. The spindle protein CHICA mediates localization of the chromokinesin Kid to the mitotic spindle. Santamaria A, et al. Curr Biol, 2008 May 20. PMID 18485706
    4. Proteome analysis of the human mitotic spindle. Sauer G, et al. Mol Cell Proteomics, 2005 Jan. PMID 15561729
    5. Conserved oncogenic behavior of the FAM83 family regulates MAPK signaling in human cancer. Cipriano R, et al. Mol Cancer Res, 2014 Aug. PMID 24736947, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables kinesin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables microtubule binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein kinase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in epithelial to mesenchymal transition ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in metaphase chromosome alignment ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cell cycle G1/S phase transition IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of cell cycle G1/S phase transition ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein localization to mitotic spindle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein localization to mitotic spindle ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of ERK1 and ERK2 cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of ERK1 and ERK2 cascade ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of TOR signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of TOR signaling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intercellular bridge IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in intercellular bridge ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in microtubule cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitotic spindle ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in mitotic spindle pole IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitotic spindle pole ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in spindle ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    protein FAM83D

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107796.1 → NP_001101266.1  protein FAM83D

      See identical proteins and their annotated locations for NP_001101266.1

      Status: PROVISIONAL

      Source sequence(s)
      CH474005
      UniProtKB/TrEMBL
      A6JWX9, D4ABG0
      Related
      ENSRNOP00000021308.2, ENSRNOT00000021308.6
      Conserved Domains (2) summary
      pfam13091
      Location:149 → 284
      PLDc_2; PLD-like domain
      cl15239
      Location:21 → 291
      PLDc_SF; Catalytic domain of phospholipase D superfamily proteins

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      167841748..167861062
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063283852.1 → XP_063139922.1  protein FAM83D isoform X3

    2. XM_039105094.2 → XP_038961022.1  protein FAM83D isoform X2

      Conserved Domains (1) summary
      cl15239
      Location:1 → 128
      PLDc_SF; Catalytic domain of phospholipase D superfamily proteins

    3. XM_039105095.2 → XP_038961023.1  protein FAM83D isoform X2

      Conserved Domains (1) summary
      cl15239
      Location:1 → 128
      PLDc_SF; Catalytic domain of phospholipase D superfamily proteins

    4. XM_039105093.1 → XP_038961021.1  protein FAM83D isoform X1

      Conserved Domains (1) summary
      cl15239
      Location:2 → 134
      PLDc_SF; Catalytic domain of phospholipase D superfamily proteins
    Nucleotide Protein Strain
    Heading Accession and Version

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