Slc22a19 solute carrier family 22, member 19 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Slc22a19provided by RGD
Official Full Name: solute carrier family 22, member 19provided by RGD
Primary source: RGD:628885
See related: EnsemblRapid:ENSRNOG00000056396 AllianceGenome:RGD:628885
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Oat5; rOat5; Slc22a9; Slc22a24
Summary: Enables organic anion transmembrane transporter activity. Involved in response to molecule of fungal origin. Located in apical plasma membrane. [provided by Alliance of Genome Resources, Dec 2024]
Expression: Restricted expression toward (RPKM 335.0) See more
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Genomic context

Location:: 1q43

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (214339594..214394681, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (204910450..204965538, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (222969899..223522893, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Utility of urinary organic anion transporter 5 as an early biomarker of obstructive nephropathy.
Title: Utility of urinary organic anion transporter 5 as an early biomarker of obstructive nephropathy.
Cholestasis induced by common bile duct ligation in the rat induces upregulation of Oat5 in kidneys.
Title: Expression of renal Oat5 and NaDC1 transporters in rats with acute biliary obstruction.
An increased expression of Oat5 in renal homogenates, in apical membranes, and in its urinary excretion was observed in rats with vascular calcification.
Title: Organic anion transporter 5 renal expression and urinary excretion in rats with vascular calcification.
renal expression of Oat5 in rats (and mice) exhibits zonal and sex differences
Title: Renal expression of organic anion transporter Oat5 in rats and mice exhibits the female-dominant sex differences.
Urinary excretion of Oat5 might be an early indicator of renal dysfunction
Title: Oat5 and NaDC1 protein abundance in kidney and urine after renal ischemic reperfusion injury.
rOat5 is renal organic anion/dicarboxylates exchanger and, under physiological conditions, may function as an apical reabsorptive pathway
Title: Functional characterization of rat organic anion transporter 5 (Slc22a19) at the apical membrane of renal proximal tubules.
Highly expressed in kidney. Motive forces behind Oat5 function, which provide insight into its membrane localization, need to be further resolved.
Title: Identification and functional assessment of the novel murine organic anion transporter Oat5 (Slc22a19) expressed in kidney.

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables organic anion transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables organic anion transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables toxin transmembrane transporter activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in monoatomic ion transport	IEA Inferred from Electronic Annotation more info
involved_in organic anion transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within organic anion transport	ISO Inferred from Sequence Orthology more info
involved_in response to molecule of fungal origin	IDA Inferred from Direct Assay more info	PubMed
involved_in steroid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in sterol transmembrane transport	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: steroid transmembrane transporter SLC22A24

Names: organic anion transporter 5; solute carrier family 22 (organic anion transporter), member 19; solute carrier family 22 (organic anion transporter), member 9; solute carrier family 22 (organic anion/cation transporter), member 9; solute carrier family 22 member 10; solute carrier family 22, member 24

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.