Pp2d1 protein phosphatase 2C-like domain containing 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Pp2d1provided by RGD
Official Full Name: protein phosphatase 2C-like domain containing 1provided by RGD
Primary source: RGD:1564811
See related: EnsemblRapid:ENSRNOG00000004719 AllianceGenome:RGD:1564811
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1564811
Summary: Predicted to enable protein serine/threonine phosphatase activity. Predicted to be involved in negative regulation of MAPK cascade and signal transduction. Predicted to be active in cytoplasm and nucleus. Orthologous to human PP2D1 (protein phosphatase 2C like domain containing 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Testes (RPKM 103.7), Lung (RPKM 66.8) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 9q11

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	9	NC_086027.1 (6749236..6770235, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	9	NC_051344.1 (6512282..6533653, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	14	NC_005113.4 (72948241..72970335, complement)

Chromosome 9 - NC_086027.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

AU048967 (e-PCR)
- UniSTS:145417

RH129271 (e-PCR)
- UniSTS:212578

RH132760 (e-PCR)
- UniSTS:216043

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables protein serine/threonine phosphatase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in negative regulation of MAPK cascade	IBA Inferred from Biological aspect of Ancestor more info
involved_in signal transduction	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: protein phosphatase 2C-like domain-containing protein 1

Names: PP2C-like domain-containing protein C3orf48 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001134567.1 → NP_001128039.1 protein phosphatase 2C-like domain-containing protein 1

See identical proteins and their annotated locations for NP_001128039.1

Status: PROVISIONAL

Source sequence(s)

CH474184

UniProtKB/TrEMBL

A6KUI3, D3ZZT7

Related

ENSRNOP00000006325.7, ENSRNOT00000006325.8

Conserved Domains (1) summary

cd00143
Location:188 → 473

PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...