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    Pck1 phosphoenolpyruvate carboxykinase 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 362282, updated on 9-Dec-2024

    Summary

    Official Symbol
    Pck1provided by RGD
    Official Full Name
    phosphoenolpyruvate carboxykinase 1provided by RGD
    Primary source
    RGD:3267
    See related
    EnsemblRapid:ENSRNOG00000028616 AllianceGenome:RGD:3267
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    GTP; PCK; Pepck; PEPCK-C; RATPEPCK
    Summary
    Enables several functions, including anion binding activity; manganese ion binding activity; and nucleoside diphosphate kinase activity. Involved in several processes, including cellular response to carbohydrate stimulus; cellular response to peptide hormone stimulus; and cellular response to salt stress. Located in cytoplasm. Used to study type 2 diabetes mellitus. Biomarker of metabolic dysfunction-associated steatohepatitis. Human ortholog(s) of this gene implicated in Alzheimer's disease and type 2 diabetes mellitus. Orthologous to human PCK1 (phosphoenolpyruvate carboxykinase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 8650.8), Liver (RPKM 2902.4) and 2 other tissues See more
    Orthologs
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    Genomic context

    See Pck1 in Genome Data Viewer
    Location:
    3q42
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (182348572..182354521)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (161930256..161936205)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (171213936..171219885)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene CCCTC-binding factor like 1 Neighboring gene ubiquitin-60S ribosomal protein L40 pseudogene Neighboring gene uncharacterized LOC120101816 Neighboring gene uncharacterized LOC102550673

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    General gene information

    Clone Names

    • MGC93820

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables GDP binding PubMed 
    enables GTP binding PubMed 
    enables GTP binding  
    enables carboxylic acid binding PubMed 
    enables carboxylic acid binding  
    enables magnesium ion binding  
    enables magnesium ion binding PubMed 
    enables manganese ion binding  
    enables manganese ion binding PubMed 
    enables manganese ion binding  
    enables nucleoside diphosphate kinase activity PubMed 
    enables phosphoenolpyruvate carboxykinase (GTP) activity  
    enables phosphoenolpyruvate carboxykinase (GTP) activity PubMed 
    enables phosphoenolpyruvate carboxykinase (GTP) activity  
    enables phosphoenolpyruvate carboxykinase activity PubMed 
    enables phosphoenolpyruvate carboxykinase activity  
    enables protein serine kinase activity (using GTP as donor)  
    enables protein serine kinase activity (using GTP as donor)  
    Items 1 - 25 of 60
    Process Evidence Code Pubs
    involved_in cellular hyperosmotic response PubMed 
    involved_in cellular hyperosmotic salinity response PubMed 
    involved_in cellular hypotonic response PubMed 
    involved_in cellular hypotonic salinity response PubMed 
    involved_in cellular response to cAMP PubMed 
    involved_in cellular response to dexamethasone stimulus  
    involved_in cellular response to fructose stimulus PubMed 
    involved_in cellular response to glucagon stimulus PubMed 
    involved_in cellular response to glucose stimulus  
    involved_in cellular response to glucose stimulus PubMed 
    involved_in cellular response to glucose stimulus  
    involved_in cellular response to hypoxia PubMed 
    involved_in cellular response to insulin stimulus  
    involved_in cellular response to insulin stimulus PubMed 
    involved_in cellular response to insulin stimulus  
    involved_in cellular response to insulin stimulus  
    involved_in cellular response to interleukin-1 PubMed 
    involved_in cellular response to phorbol 13-acetate 12-myristate PubMed 
    acts_upstream_of_or_within cellular response to potassium ion starvation  
    involved_in cellular response to raffinose PubMed 
    involved_in cellular response to retinoic acid PubMed 
    involved_in cellular response to tumor necrosis factor PubMed 
    involved_in gluconeogenesis  
    involved_in gluconeogenesis PubMed 
    involved_in gluconeogenesis  
    acts_upstream_of_or_within gluconeogenesis  
    involved_in gluconeogenesis  
    involved_in gluconeogenesis PubMed 
    involved_in glucose homeostasis PubMed 
    involved_in glucose metabolic process PubMed 
    involved_in glucose metabolic process  
    involved_in glyceraldehyde-3-phosphate biosynthetic process  
    involved_in glycerol biosynthetic process from pyruvate  
    involved_in glycerol biosynthetic process from pyruvate PubMed 
    acts_upstream_of_or_within glycerol biosynthetic process from pyruvate  
    involved_in hepatocyte differentiation  
    acts_upstream_of_or_within lipid metabolic process  
    involved_in oxaloacetate metabolic process  
    involved_in oxaloacetate metabolic process PubMed 
    involved_in oxaloacetate metabolic process  
    involved_in peptidyl-serine phosphorylation  
    involved_in peptidyl-serine phosphorylation  
    involved_in positive regulation of lipid biosynthetic process  
    involved_in positive regulation of memory T cell differentiation  
    involved_in positive regulation of memory T cell differentiation  
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II  
    involved_in propionate catabolic process  
    involved_in regulation of lipid biosynthetic process  
    involved_in regulation of lipid biosynthetic process  
    involved_in response to activity PubMed 
    acts_upstream_of_or_within response to bacterium  
    involved_in response to insulin  
    involved_in response to insulin PubMed 
    involved_in response to interleukin-6 PubMed 
    involved_in response to lipid PubMed 
    involved_in response to lipopolysaccharide PubMed 
    involved_in response to methionine PubMed 
    involved_in response to nutrient levels PubMed 
    involved_in response to starvation  
    involved_in tricarboxylic acid metabolic process  
    Items 1 - 25 of 60
    Component Evidence Code Pubs
    located_in cytoplasm PubMed 
    is_active_in cytosol  
    is_active_in cytosol  
    located_in cytosol  
    located_in cytosol  
    located_in cytosol  
    located_in endoplasmic reticulum  
    located_in endoplasmic reticulum  
    is_active_in mitochondrion  

    General protein information

    Preferred Names
    phosphoenolpyruvate carboxykinase, cytosolic [GTP]
    Names
    phosphoenolpyruvate carboxykinase (GTP)
    phosphoenolpyruvate carboxykinase 1 (soluble)
    phosphoenolpyruvate carboxykinase 1, cytosolic
    phosphoenolpyruvate carboxykinase, cytosolic (GTP)
    phosphoenolpyruvate carboxylase
    serine-protein kinase PCK1
    NP_942075.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_198780.3NP_942075.1  phosphoenolpyruvate carboxykinase, cytosolic [GTP]

      See identical proteins and their annotated locations for NP_942075.1

      Status: VALIDATED

      Source sequence(s)
      BC081900, JAXUCZ010000003
      UniProtKB/Swiss-Prot
      P07379
      UniProtKB/TrEMBL
      A6KKZ5
      Related
      ENSRNOP00000030913.5, ENSRNOT00000031586.8
      Conserved Domains (1) summary
      cd00819
      Location:27615
      PEPCK_GTP; Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      182348572..182354521
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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