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    Tbc1d20 TBC1 domain family, member 20 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 362237, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Tbc1d20provided by RGD
    Official Full Name
    TBC1 domain family, member 20provided by RGD
    Primary source
    RGD:1303293
    See related
    EnsemblRapid:ENSRNOG00000005766 AllianceGenome:RGD:1303293
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable GTPase activator activity and small GTPase binding activity. Predicted to be involved in several processes, including COPII-coated vesicle cargo loading; positive regulation by host of viral genome replication; and positive regulation by virus of viral protein levels in host cell. Predicted to act upstream of or within several processes, including acrosome assembly; lens fiber cell morphogenesis; and seminiferous tubule development. Predicted to be located in Golgi membrane; endoplasmic reticulum; and nuclear membrane. Predicted to be active in endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in Warburg micro syndrome 4. Orthologous to human TBC1D20 (TBC1 domain family member 20). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 310.9), Adrenal (RPKM 255.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Tbc1d20 in Genome Data Viewer
    Location:
    3q41
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (161228699..161247319)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (140768537..140787010)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (147772006..147790946)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene transcription factor 15 Neighboring gene casein kinase 2 alpha 1 Neighboring gene RANBP2-type and C3HC4-type zinc finger containing 1 Neighboring gene tribbles pseudokinase 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Role for TBC1D20 and Rab1 in hepatitis C virus replication via interaction with lipid droplet-bound nonstructural protein 5A. Nevo-Yassaf I, et al. J Virol, 2012 Jun. PMID 22491470, Free PMC Article
    2. A Rab-GAP TBC domain protein binds hepatitis C virus NS5A and mediates viral replication. Sklan EH, et al. J Virol, 2007 Oct. PMID 17686842, Free PMC Article
    3. Production of fertile offspring from genetically infertile male mice. Yanagimachi R, et al. Proc Natl Acad Sci U S A, 2004 Feb 10. PMID 14757819, Free PMC Article
    4. Analysis of Rab GTPase-activating proteins indicates that Rab1a/b and Rab43 are important for herpes simplex virus 1 secondary envelopment. Zenner HL, et al. J Virol, 2011 Aug. PMID 21680502, Free PMC Article
    5. Analysis of GTPase-activating proteins: Rab1 and Rab43 are key Rabs required to maintain a functional Golgi complex in human cells. Haas AK, et al. J Cell Sci, 2007 Sep 1. PMID 17684057

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC94895

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables GTPase activator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables small GTPase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in COPII-coated vesicle cargo loading ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within Golgi organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in Golgi organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within acrosome assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within camera-type eye development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within lens development in camera-type eye ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within lens fiber cell morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within lipid droplet organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within male gonad development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation by host of viral genome replication ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation by virus of viral protein levels in host cell ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of ER to Golgi vesicle-mediated transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of GTPase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    NOT involved_in regulation of cilium assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within seminiferous tubule development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within spermatogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in virion assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    TBC1 domain family member 20

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001004281.1 → NP_001004281.1  TBC1 domain family member 20

      See identical proteins and their annotated locations for NP_001004281.1

      Status: PROVISIONAL

      Source sequence(s)
      BC079383
      UniProtKB/TrEMBL
      A6KHM6, F7EVY6, Q6AXR1
      Conserved Domains (1) summary
      pfam00566
      Location:62 → 265
      RabGAP-TBC; Rab-GTPase-TBC domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      161228699..161247319
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063284174.1 → XP_063140244.1  TBC1 domain family member 20 isoform X3

      Related
      ENSRNOP00000008713.3, ENSRNOT00000008713.6

    2. XM_063284176.1 → XP_063140246.1  TBC1 domain family member 20 isoform X6

    3. XM_039105485.2 → XP_038961413.1  TBC1 domain family member 20 isoform X5

      Conserved Domains (1) summary
      cl02495
      Location:101 → 247
      RabGAP-TBC; Rab-GTPase-TBC domain

    4. XM_039105483.2 → XP_038961411.1  TBC1 domain family member 20 isoform X2

      Conserved Domains (1) summary
      pfam00566
      Location:101 → 295
      RabGAP-TBC; Rab-GTPase-TBC domain

    5. XM_039105482.2 → XP_038961410.1  TBC1 domain family member 20 isoform X1

      Conserved Domains (1) summary
      pfam00566
      Location:101 → 304
      RabGAP-TBC; Rab-GTPase-TBC domain

    6. XM_063284175.1 → XP_063140245.1  TBC1 domain family member 20 isoform X4

    Nucleotide Protein Strain
    Heading Accession and Version

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