Rfpl4a ret finger protein-like 4A [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Rfpl4aprovided by RGD
Official Full Name: ret finger protein-like 4Aprovided by RGD
Primary source: RGD:1307409
See related: EnsemblRapid:ENSRNOG00000015743 AllianceGenome:RGD:1307409
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Rfpl4
Summary: Predicted to enable protein homodimerization activity; protein kinase binding activity; and ubiquitin protein ligase activity. Predicted to be involved in several processes, including positive regulation of autophagy; positive regulation of canonical NF-kappaB signal transduction; and regulation of viral entry into host cell. Predicted to be located in female germ cell nucleus. Predicted to be active in cytosol and nucleoplasm. Orthologous to several human genes including RFPL4A (ret finger protein like 4A). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Testes (RPKM 1.1), Heart (RPKM 0.9) and 8 other tissues See more
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Genomic context

Location:: 1q12

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (77757811..77764270)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (68728964..68735423)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (72280117..72286784)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables ubiquitin protein ligase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in innate immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of gene expression	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in female germ cell nucleus	ISO Inferred from Sequence Orthology more info
NOT located_in nucleolus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: ret finger protein-like 4A

Names: ret finger protein-like 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001106222.1 → NP_001099692.1 ret finger protein-like 4A

See identical proteins and their annotated locations for NP_001099692.1

Status: PROVISIONAL

Source sequence(s)

CH474075

UniProtKB/Swiss-Prot

D4ABM4

Related

ENSRNOP00000021077.4, ENSRNOT00000021077.6

Conserved Domains (4) summary

cd15821
Location:94 → 270

SPRY_PRY_RFPL; Ret finger protein-like (RFPL), includes RFP1, 2, 3, 4

cd00162
Location:11 → 52

RING_Ubox; variant RING-HC finger (C4C4-type) [structural motif]

pfam11002
Location:54 → 95

RDM; RFPL defining motif (RDM)

cl17238
Location:10 → 53

RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain