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    Nodal nodal growth differentiation factor [ Rattus norvegicus (Norway rat) ]

    Gene ID: 294503, updated on 9-Dec-2024

    Summary

    Official Symbol
    Nodalprovided by RGD
    Official Full Name
    nodal growth differentiation factorprovided by RGD
    Primary source
    RGD:1305994
    See related
    EnsemblRapid:ENSRNOG00000000556 AllianceGenome:RGD:1305994
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable cytokine activity and type I activin receptor binding activity. Involved in female pregnancy. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in visceral heterotaxy. Orthologous to human NODAL (nodal growth differentiation factor). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 1.2), Testes (RPKM 0.8) and 9 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Nodal in Genome Data Viewer
    Location:
    20q11
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (29911258..29919659)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (29368436..29376837)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (31035729..31044096)

    Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene perforin 1 Neighboring gene phosphatase domain containing, paladin 1 Neighboring gene eukaryotic translation initiation factor 4E binding protein 2 Neighboring gene cysteine and glycine-rich protein 2, pseudogene 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables cytokine activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables growth factor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables receptor ligand activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables type I activin receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within anatomical structure formation involved in morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within anterior/posterior axis specification ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within anterior/posterior pattern specification ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within axial mesodermal cell fate specification ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within brain development ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within cell fate commitment ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within cell migration involved in gastrulation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in determination of left/right asymmetry in lateral mesoderm ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within determination of left/right symmetry ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within digestive system development ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within digestive tract morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within embryonic cranial skeleton morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within embryonic heart tube development ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within embryonic pattern specification ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within embryonic placenta development ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within embryonic process involved in female pregnancy ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within endoderm development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in endodermal cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within epiblast cell-extraembryonic ectoderm cell signaling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in female pregnancy IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    acts_upstream_of_or_within floor plate morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within formation of anatomical boundary ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within gastrulation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within gastrulation with mouth forming second ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of germ cell development ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within heart development ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within heart looping ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within in utero embryonic development ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within inhibition of neuroepithelial cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within left lung morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within liver development ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within lung development ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within maternal placenta development ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within maternal process involved in parturition ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within mesendoderm development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in mesendoderm development ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within mesoderm formation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of androgen receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within negative regulation of cell development ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within negative regulation of cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of chorionic trophoblast cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within negative regulation of reproductive process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of trophoblast cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within nervous system development ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within neural fold formation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in nodal signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in placenta development ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within polarity specification of proximal/distal axis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of DNA-binding transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of ERK1 and ERK2 cascade ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of SMAD protein signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of angiogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cell-cell adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of epithelial cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of vascular endothelial growth factor production ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within primitive streak formation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of gastrulation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within somatic stem cell population maintenance ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within stem cell population maintenance ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within tissue morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within transforming growth factor beta receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within trophectodermal cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within trophectodermal cellular morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within vasculature development ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in extracellular region ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
     

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106394.1NP_001099864.1  nodal homolog precursor

      See identical proteins and their annotated locations for NP_001099864.1

      Status: PROVISIONAL

      Source sequence(s)
      CH474016
      UniProtKB/TrEMBL
      A6K3Z7, D3ZGK9
      Related
      ENSRNOP00000000672.2, ENSRNOT00000000672.6
      Conserved Domains (2) summary
      cd13759
      Location:252353
      TGF_beta_NODAL; transforming growth factor beta (TGF-beta) like domain found in Nodal (NODAL)-related proteins
      cl02928
      Location:29168
      TGFb_propeptide; TGF-beta propeptide

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086038.1 Reference GRCr8

      Range
      29911258..29919659
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)