Efna2 ephrin A2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Efna2provided by RGD
Official Full Name: ephrin A2provided by RGD
Primary source: RGD:620389
See related: EnsemblRapid:ENSRNOG00000016203 AllianceGenome:RGD:620389
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable ephrin receptor binding activity. Involved in axon guidance and olfactory bulb development. Located in neuromuscular junction and perikaryon. Orthologous to human EFNA2 (ephrin A2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 12.0), Thymus (RPKM 7.3) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 7q11

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (10167091..10177719, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (9515635..9528071, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (12382636..12393266, complement)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Ephrin-A2, in concert with one or more Eph receptors, may be postnatally involved in arbor development of thalamocortical axons at cortical layer IV boundaries.
Title: Laminar expression of ephrin-A2 in primary somatosensory cortex of postnatal rats.
It is notable that the up-regulation of ephrin mRNAs occurs during the reorganization in the deafferented hippocampus, suggesting that ephrins may be involved in the plasticity events of the adult brain after lesion.
Title: Semi-quantitative expression analysis of ephrin mRNAs in the deafferented hippocampus.
The repulsive ephrin-A2 environment offers at least a partial explanation for the observation that only a limited number of retinal ganglion cell axons can exit nerve graft to enter target central nervous system tissue.
Title: EphA5 and ephrin-A2 expression during optic nerve regeneration: a 'two-edged sword'.
Ephrin A2 expression is restricted to the adult thymic medullary epithelial cells and some perivascular and peritrabecular areas.
Title: Expression and function of the Eph A receptors and their ligands ephrins A in the rat thymus.

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ephrin receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables ephrin receptor binding	ISO Inferred from Sequence Orthology more info
enables ephrin receptor binding	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in axon guidance	IBA Inferred from Biological aspect of Ancestor more info
involved_in axon guidance	IEP Inferred from Expression Pattern more info	PubMed
involved_in bone remodeling	IBA Inferred from Biological aspect of Ancestor more info
involved_in bone remodeling	ISO Inferred from Sequence Orthology more info
involved_in ephrin receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in ephrin receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in ephrin receptor signaling pathway	TAS Traceable Author Statement more info	PubMed
involved_in inner ear morphogenesis	TAS Traceable Author Statement more info	PubMed
involved_in olfactory bulb development	IEP Inferred from Expression Pattern more info	PubMed
involved_in osteoclast differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in osteoclast differentiation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in neuromuscular junction	IDA Inferred from Direct Assay more info	PubMed
located_in perikaryon	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in side of membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: ephrin-A2

Names: ephrin A-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.