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    St13 ST13, Hsp70 interacting protein [ Rattus norvegicus (Norway rat) ]

    Gene ID: 81800, updated on 9-Dec-2024

    Summary

    Official Symbol
    St13provided by RGD
    Official Full Name
    ST13, Hsp70 interacting proteinprovided by RGD
    Primary source
    RGD:621312
    See related
    EnsemblRapid:ENSRNOG00000018920 AllianceGenome:RGD:621312
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables several functions, including Hsp70 protein binding activity; dATP binding activity; and unfolded protein binding activity. Involved in chaperone cofactor-dependent protein refolding and negative regulation of protein refolding. Part of protein-containing complex. Orthologous to several human genes including ST13 (ST13 Hsp70 interacting protein) and ST13P5 (ST13, Hsp70 interacting protein pseudogene 5). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 684.5), Liver (RPKM 640.3) and 9 other tissues See more
    Orthologs
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    Genomic context

    See St13 in Genome Data Viewer
    Location:
    7q34
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (114769758..114805877, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (112891007..112925727, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (122585770..122635731, complement)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120093696 Neighboring gene solute carrier family 25 member 17 Neighboring gene uncharacterized LOC134479943 Neighboring gene X-prolyl aminopeptidase 3 Neighboring gene DnaJ heat shock protein family (Hsp40) member B7 Neighboring gene ribosomal protein L37A, pseudogene 2

    Genomic regions, transcripts, and products

    Bibliography

    Pathways from PubChem

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables Hsp70 protein binding  
    enables Hsp70 protein binding PubMed 
    enables Hsp70 protein binding PubMed 
    enables dATP binding PubMed 
    enables identical protein binding PubMed 
    enables protein binding PubMed 
    enables protein dimerization activity  
    enables protein domain specific binding PubMed 
    enables protein domain specific binding PubMed 
    enables protein-containing complex binding PubMed 
    enables protein-folding chaperone binding PubMed 
    enables unfolded protein binding PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm  
    located_in cytosol  
    part_of protein-containing complex PubMed 

    General protein information

    Preferred Names
    hsc70-interacting protein
    Names
    hip
    protein ST13 homolog
    suppression of tumorigenicity 13 (colon carcinoma) Hsp70-interacting protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_031122.2NP_112384.1  hsc70-interacting protein

      See identical proteins and their annotated locations for NP_112384.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/Swiss-Prot
      P50503
      UniProtKB/TrEMBL
      A0A8I5ZYX0, A6HSZ6
      Related
      ENSRNOP00000084383.1, ENSRNOT00000107864.2
      Conserved Domains (5) summary
      smart00727
      Location:318357
      STI1; Heat shock chaperonin-binding motif
      cd14438
      Location:343
      Hip_N; N-terminal dimerization domain of the Hsp70-interacting protein (Hip) and similar proteins
      sd00006
      Location:113141
      TPR; TPR repeat [structural motif]
      pfam00515
      Location:147179
      TPR_1; Tetratricopeptide repeat
      pfam13414
      Location:112178
      TPR_11; TPR repeat

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      114769758..114805877 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063264299.1XP_063120369.1  hsc70-interacting protein isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZYX0, A0A8I6A6M6
      Related
      ENSRNOP00000088669.1, ENSRNOT00000117864.2
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