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    Spock1 sparc/osteonectin, cwcv and kazal like domains proteoglycan 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 306759, updated on 9-Dec-2024

    Summary

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    Symbol
    Spock1provided by RGD
    Full Name
    sparc/osteonectin, cwcv and kazal like domains proteoglycan 1provided by RGD
    Primary source
    RGD:1311496
    See related
    EnsemblRapid:ENSRNOG00000012747 AllianceGenome:RGD:1311496
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable calcium ion binding activity; cysteine-type endopeptidase inhibitor activity; and metalloendopeptidase inhibitor activity. Predicted to be involved in several processes, including generation of neurons; negative regulation of cell-substrate adhesion; and negative regulation of endopeptidase activity. Predicted to be located in neuromuscular junction; node of Ranvier; and sarcoplasm. Predicted to be active in extracellular space and postsynaptic density. Human ortholog(s) of this gene implicated in hepatocellular carcinoma. Orthologous to human SPOCK1 (SPARC (osteonectin), cwcv and kazal like domains proteoglycan 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 245.8) and Liver (RPKM 13.7) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Spock1 in Genome Data Viewer
    Location:
    17p14
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (6746892..7227034)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (6741504..7221685)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (7675531..7797863)

    Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134482666 Neighboring gene kelch-like family member 3 Neighboring gene microRNA 874 Neighboring gene non-histone chromosomal protein HMG-17-like Neighboring gene uncharacterized LOC120097735 Neighboring gene uncharacterized LOC134482667 Neighboring gene uncharacterized LOC120097750 Neighboring gene uncharacterized LOC108348497 Neighboring gene uncharacterized LOC120097914

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Testican-1 inhibits attachment of Neuro-2a cells. Marr HS, et al. Matrix Biol, 2003 May. PMID 12853036
    2. Expression of the proteoglycan SPOCK during mouse embryo development. Charbonnier F, et al. Mech Dev, 2000 Feb. PMID 10640720
    3. Properties of the extracellular calcium binding module of the proteoglycan testican. Kohfeldt E, et al. FEBS Lett, 1997 Sep 15. PMID 9323035
    4. Regulated expression of the proteoglycan SPOCK in the neuromuscular system. Cifuentes-Diaz C, et al. Mech Dev, 2000 Jun. PMID 10842087
    5. Human proteoglycan testican-1 inhibits the lysosomal cysteine protease cathepsin L. Bocock JP, et al. Eur J Biochem, 2003 Oct. PMID 14511383

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables calcium ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables cysteine-type endopeptidase inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metalloendopeptidase inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in central nervous system neuron differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in establishment of protein localization to extracellular region IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of cell-substrate adhesion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of endopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of neuron projection development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in neurogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in neuron migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in neuromuscular junction ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in node of Ranvier ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in postsynaptic density ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in sarcoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    testican-1
    Names
    sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001271297.1 → NP_001258226.1  testican-1

      See identical proteins and their annotated locations for NP_001258226.1

      Status: VALIDATED

      Source sequence(s)
      BC092615, CB608950, CB713141, JAXUCZ010000017
      UniProtKB/TrEMBL
      A6KAL9, F1M6V6
      Related
      ENSRNOP00000057901.5, ENSRNOT00000061187.5
      Conserved Domains (4) summary
      smart00280
      Location:137 → 178
      KAZAL; Kazal type serine protease inhibitors
      cd00191
      Location:314 → 375
      TY; Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases
      cd00252
      Location:199 → 317
      SPARC_EC; SPARC_EC; extracellular Ca2+ binding domain (containing 2 EF-hand motifs) of SPARC and related proteins (QR1, SC1/hevin, testican and tsc-36/FRP). SPARC (BM-40) is a multifunctional glycoprotein, a matricellular protein, that functions to regulate ...
      pfam10591
      Location:198 → 304
      SPARC_Ca_bdg; Secreted protein acidic and rich in cysteine Ca binding region

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086035.1 Reference GRCr8

      Range
      6746892..7227034
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063276334.1 → XP_063132404.1  testican-1 isoform X1

    2. XM_063276335.1 → XP_063132405.1  testican-1 isoform X2

    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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