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    Cacng5 calcium voltage-gated channel auxiliary subunit gamma 5 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 140726, updated on 9-Dec-2024

    Summary

    Official Symbol
    Cacng5provided by RGD
    Official Full Name
    calcium voltage-gated channel auxiliary subunit gamma 5provided by RGD
    Primary source
    RGD:628805
    See related
    EnsemblRapid:ENSRNOG00000003288 AllianceGenome:RGD:628805
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable channel regulator activity and voltage-gated calcium channel activity. Involved in regulation of AMPA receptor activity. Located in postsynaptic density. Part of AMPA glutamate receptor complex. Is active in glutamatergic synapse and postsynaptic membrane. Orthologous to human CACNG5 (calcium voltage-gated channel auxiliary subunit gamma 5). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 46.6), Brain (RPKM 37.8) and 2 other tissues See more
    Orthologs
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    Genomic context

    See Cacng5 in Genome Data Viewer
    Location:
    10q32.1
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (93327142..93369244, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (92827441..92869632, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (96122240..96166606, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108352150 Neighboring gene calcium voltage-gated channel auxiliary subunit gamma 4 Neighboring gene uncharacterized LOC108352151 Neighboring gene protein kinase C, alpha Neighboring gene apolipoprotein H

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables channel regulator activity  
    enables protein binding PubMed 
    enables voltage-gated calcium channel activity  
    Component Evidence Code Pubs
    part_of AMPA glutamate receptor complex  
    part_of AMPA glutamate receptor complex PubMed 
    is_active_in glutamatergic synapse PubMed 
    is_active_in glutamatergic synapse PubMed 
    is_active_in glutamatergic synapse  
    located_in postsynaptic density PubMed 
    is_active_in postsynaptic density membrane  
    is_active_in postsynaptic membrane PubMed 
    is_active_in postsynaptic membrane PubMed 

    General protein information

    Preferred Names
    voltage-dependent calcium channel gamma-5 subunit
    Names
    TARP gamma-5
    calcium channel, voltage-dependent, gamma subunit 5
    neuronal voltage-gated calcium channel gamma-5 subunit
    transmembrane AMPAR regulatory protein gamma-5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_080693.3NP_542424.1  voltage-dependent calcium channel gamma-5 subunit

      See identical proteins and their annotated locations for NP_542424.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/Swiss-Prot
      Q8VHW8
      UniProtKB/TrEMBL
      A6HK88
      Related
      ENSRNOP00000004578.6, ENSRNOT00000004578.9
      Conserved Domains (1) summary
      cl21598
      Location:18195
      PMP22_Claudin; PMP-22/EMP/MP20/Claudin family

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      93327142..93369244 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039085092.2XP_038941020.1  voltage-dependent calcium channel gamma-5 subunit isoform X1

      UniProtKB/Swiss-Prot
      Q8VHW8
      UniProtKB/TrEMBL
      A6HK88
      Conserved Domains (1) summary
      cl21598
      Location:18195
      PMP22_Claudin; PMP-22/EMP/MP20/Claudin family
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