Pdxk pyridoxal kinase [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Pdxkprovided by RGD
Full Name: pyridoxal kinaseprovided by RGD
Primary source: RGD:621324
See related: EnsemblRapid:ENSRNOG00000049937 AllianceGenome:RGD:621324
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables pyridoxal binding activity and pyridoxal kinase activity. Involved in several processes, including pyridoxal phosphate biosynthetic process; response to X-ray; and response to progesterone. Predicted to be active in cytosol. Orthologous to human PDXK (pyridoxal kinase). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Kidney (RPKM 526.8), Liver (RPKM 158.7) and 7 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 20p12

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	20	NC_086038.1 (10209975..10232012)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	20	NC_051355.1 (10210276..10232314)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	20	NC_005119.4 (10930651..10952194)

Chromosome 20 - NC_086038.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

Pdxk (e-PCR), detects polymorphism
- UniSTS:259127

RH126288 (e-PCR)
- UniSTS:162996

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables organic cyclic compound binding	IPI Inferred from Physical Interaction more info	PubMed
enables phosphotransferase activity, alcohol group as acceptor	ISO Inferred from Sequence Orthology more info
enables pyridoxal binding	IDA Inferred from Direct Assay more info	PubMed
enables pyridoxal kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables pyridoxal kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables pyridoxal kinase activity	IEA Inferred from Electronic Annotation more info
enables pyridoxal kinase activity	ISO Inferred from Sequence Orthology more info
enables small molecule binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in negative regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in pyridoxal 5'-phosphate salvage	IBA Inferred from Biological aspect of Ancestor more info
involved_in pyridoxal 5'-phosphate salvage	IEA Inferred from Electronic Annotation more info
involved_in pyridoxal metabolic process	ISO Inferred from Sequence Orthology more info
involved_in pyridoxal phosphate biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in pyridoxal phosphate metabolic process	ISO Inferred from Sequence Orthology more info
involved_in pyridoxamine metabolic process	ISO Inferred from Sequence Orthology more info
involved_in response to X-ray	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to amine	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to food	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to insecticide	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to progesterone	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to toxic substance	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to xenobiotic stimulus	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytosol	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: pyridoxal kinase

Names: pyridoxal (pyridoxine, vitamin B6) kinase; pyridoxine kinase

NP_113957.2

EC 2.7.1.35

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.