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    Bicc1 BicC family RNA binding protein 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 361832, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Bicc1provided by RGD
    Official Full Name
    BicC family RNA binding protein 1provided by RGD
    Primary source
    RGD:1307459
    See related
    EnsemblRapid:ENSRNOG00000000614 AllianceGenome:RGD:1307459
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable RNA binding activity. Predicted to be involved in negative regulation of canonical Wnt signaling pathway. Predicted to act upstream of or within determination of left/right symmetry; heart development; and kidney development. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in diffuse cystic renal dysplasia. Orthologous to human BICC1 (BicC family RNA binding protein 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 265.9), Heart (RPKM 108.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Bicc1 in Genome Data Viewer
    Location:
    20p11
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (17448745..17685887)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (17449639..17686775)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (18780605..18940429)

    Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102548205 Neighboring gene uncharacterized LOC134483894 Neighboring gene uncharacterized LOC102548329 Neighboring gene uncharacterized LOC134483895

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. BICC1 expression is elevated in depressed subjects and contributes to depressive behavior in rodents. Ota KT, et al. Neuropsychopharmacology, 2015 Feb. PMID 25178406, Free PMC Article
    2. Two mutations in human BICC1 resulting in Wnt pathway hyperactivity associated with cystic renal dysplasia. Kraus MR, et al. Hum Mutat, 2012 Jan. PMID 21922595
    3. Global genetic analysis in mice unveils central role for cilia in congenital heart disease. Li Y, et al. Nature, 2015 May 28. PMID 25807483, Free PMC Article
    4. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Castello A, et al. Cell, 2012 Jun 8. PMID 22658674
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. findings identify a role for increased levels of BICC1 in the pathophysiology of depressive behavior
      Title: BICC1 expression is elevated in depressed subjects and contributes to depressive behavior in rodents.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within determination of left/right symmetry ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within heart development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within kidney development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of canonical Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    protein bicaudal C homolog 1
    Names
    bicaudal C homolog 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001415073.1 → NP_001402002.1  protein bicaudal C homolog 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000020
      UniProtKB/TrEMBL
      A6JKP7, D3ZDJ9
      Related
      ENSRNOP00000071622.3, ENSRNOT00000080846.3

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086038.1 Reference GRCr8

      Range
      17448745..17685887
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039098830.2 → XP_038954758.1  protein bicaudal C homolog 1 isoform X1

      UniProtKB/TrEMBL
      A6JKP7
      Conserved Domains (4) summary
      cd09520
      Location:875 → 938
      SAM_BICC1; SAM domain of BICC1 (bicaudal) subfamily
      cd22420
      Location:48 → 128
      KH-I_BICC1_rpt1; first type I K homology (KH) RNA-binding domain found in protein bicaudal C homolog 1 (BICC1) and similar proteins
      cd22421
      Location:133 → 202
      KH-I_BICC1_rpt2; second type I K homology (KH) RNA-binding domain found in protein bicaudal C homolog 1 (BICC1) and similar proteins
      cd22422
      Location:286 → 351
      KH-I_BICC1_rpt3; third type I K homology (KH) RNA-binding domain found in protein bicaudal C homolog 1 (BICC1) and similar proteins

    2. XM_039098831.2 → XP_038954759.1  protein bicaudal C homolog 1 isoform X2

      UniProtKB/TrEMBL
      A0A0G2K0Y0, A6JKP8
      Related
      ENSRNOP00000000754.7, ENSRNOT00000000754.8
      Conserved Domains (4) summary
      cd09520
      Location:876 → 934
      SAM_BICC1; SAM domain of BICC1 (bicaudal) subfamily
      cd22420
      Location:48 → 128
      KH-I_BICC1_rpt1; first type I K homology (KH) RNA-binding domain found in protein bicaudal C homolog 1 (BICC1) and similar proteins
      cd22421
      Location:133 → 202
      KH-I_BICC1_rpt2; second type I K homology (KH) RNA-binding domain found in protein bicaudal C homolog 1 (BICC1) and similar proteins
      cd22422
      Location:286 → 351
      KH-I_BICC1_rpt3; third type I K homology (KH) RNA-binding domain found in protein bicaudal C homolog 1 (BICC1) and similar proteins

    3. XM_017601688.3 → XP_017457177.1  protein bicaudal C homolog 1 isoform X3

      UniProtKB/TrEMBL
      A6JKP7

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001108531.1: Suppressed sequence

      Description
      NM_001108531.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version

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