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    Cdh19 cadherin 19 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 360835, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cdh19provided by RGD
    Official Full Name
    cadherin 19provided by RGD
    Primary source
    RGD:1307169
    See related
    EnsemblRapid:ENSRNOG00000029841 AllianceGenome:RGD:1307169
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable beta-catenin binding activity and cadherin binding activity. Predicted to be involved in several processes, including calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules; cell-cell adhesion mediated by cadherin; and cell-cell junction organization. Predicted to be part of catenin complex. Predicted to be active in adherens junction. Orthologous to human CDH19 (cadherin 19). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 22.6), Brain (RPKM 17.1) and 6 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Cdh19 in Genome Data Viewer
    Location:
    13q11
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (28450361..28561932, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (27935915..28047490, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (32344954..32469887, complement)

    Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene UPF3B, regulator of nonsense mediated mRNA decay, pseudogene 1 Neighboring gene transfer RNA alanine (anticodon AGC) 67 Neighboring gene U2 spliceosomal RNA Neighboring gene eukaryotic translation elongation factor 2, pseudogene 1 Neighboring gene dipeptidyl peptidase 3, pseudogene 1 Neighboring gene dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 4-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Identification of a novel type II classical cadherin: rat cadherin19 is expressed in the cranial ganglia and Schwann cell precursors during development. Takahashi M, et al. Dev Dyn, 2005 Jan. PMID 15580626
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. cad19 is an evolutionarily conserved cadherin and may be involved in the early development of Schwann cells in the peripheral nervous system
      Title: Identification of a novel type II classical cadherin: rat cadherin19 is expressed in the cranial ganglia and Schwann cell precursors during development.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables beta-catenin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cadherin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in adherens junction organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell-cell adhesion mediated by cadherin IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell-cell junction assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in homophilic cell adhesion via plasma membrane adhesion molecules IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in adherens junction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of catenin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    cadherin-19
    Names
    cadherin 19, type 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001009448.2 → NP_001009448.1  cadherin-19

      See identical proteins and their annotated locations for NP_001009448.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000013
      UniProtKB/TrEMBL
      Q5NUI3
      Related
      ENSRNOP00000101100.1, ENSRNOT00000122113.1
      Conserved Domains (2) summary
      cd11304
      Location:150 → 250
      Cadherin_repeat; Cadherin tandem repeat domain
      pfam01049
      Location:617 → 764
      Cadherin_C; Cadherin cytoplasmic region

    2. NM_001429618.1 → NP_001416547.1  cadherin-19

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000013
      UniProtKB/TrEMBL
      Q5NUI3

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086031.1 Reference GRCr8

      Range
      28450361..28561932 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039090879.2 → XP_038946807.1  cadherin-19 isoform X2

      UniProtKB/TrEMBL
      F7FIC1
      Related
      ENSRNOP00000047360.2, ENSRNOT00000044628.4
      Conserved Domains (2) summary
      cd11304
      Location:150 → 250
      Cadherin_repeat; Cadherin tandem repeat domain
      pfam01049
      Location:591 → 738
      Cadherin_C; Cadherin cytoplasmic region

    2. XM_017598843.3 → XP_017454332.1  cadherin-19 isoform X1

      Conserved Domains (2) summary
      cd11304
      Location:150 → 250
      Cadherin_repeat; Cadherin tandem repeat domain
      pfam01049
      Location:617 → 764
      Cadherin_C; Cadherin cytoplasmic region

    3. XM_039090877.2 → XP_038946805.1  cadherin-19 isoform X1

      Conserved Domains (2) summary
      cd11304
      Location:150 → 250
      Cadherin_repeat; Cadherin tandem repeat domain
      pfam01049
      Location:617 → 764
      Cadherin_C; Cadherin cytoplasmic region

    4. XM_039090880.2 → XP_038946808.1  cadherin-19 isoform X3

      UniProtKB/TrEMBL
      A6JSW5
      Conserved Domains (2) summary
      cd11304
      Location:234 → 325
      Cadherin_repeat; Cadherin tandem repeat domain
      pfam01049
      Location:478 → 625
      Cadherin_C; Cadherin cytoplasmic region
    Nucleotide Protein Strain
    Heading Accession and Version

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