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    Zbtb26 zinc finger and BTB domain containing 26 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 311910, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Zbtb26provided by RGD
    Official Full Name
    zinc finger and BTB domain containing 26provided by RGD
    Primary source
    RGD:1308561
    See related
    EnsemblRapid:ENSRNOG00000009346 AllianceGenome:RGD:1308561
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and identical protein binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II; regulation of cytokine production; and regulation of immune system process. Predicted to be active in nucleoplasm. Orthologous to human ZBTB26 (zinc finger and BTB domain containing 26). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 41.3), Adrenal (RPKM 38.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Zbtb26 in Genome Data Viewer
    Location:
    3q11
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (41605097..41617706, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (21195319..21207925, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (21685339..21697945, complement)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene ring finger and CCCH-type domains 2 Neighboring gene small nucleolar RNA, C/D box 90 Neighboring gene uncharacterized LOC108350365 Neighboring gene zinc finger and BTB domain containing 6 like 1 Neighboring gene zinc finger and BTB domain containing 6 Neighboring gene RAB GTPase activating protein 1 Neighboring gene G protein-coupled receptor 21 Neighboring gene spermatid perinuclear RNA binding protein Neighboring gene U4 spliceosomal RNA

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. A proteome-scale map of the human interactome network. Rolland T, et al. Cell, 2014 Nov 20. PMID 25416956, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables sequence-specific double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of cytokine production IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of immune system process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger and BTB domain-containing protein 26

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107840.1 → NP_001101310.1  zinc finger and BTB domain-containing protein 26

      See identical proteins and their annotated locations for NP_001101310.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473983
      UniProtKB/TrEMBL
      A6JET2
      Conserved Domains (5) summary
      smart00225
      Location:45 → 138
      BTB; Broad-Complex, Tramtrack and Bric a brac
      sd00017
      Location:311 → 331
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:309 → 331
      zf-C2H2; Zinc finger, C2H2 type
      pfam00651
      Location:34 → 134
      BTB; BTB/POZ domain
      pfam13465
      Location:326 → 348
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      41605097..41617706 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006234082.5 → XP_006234144.1  zinc finger and BTB domain-containing protein 26 isoform X1

      See identical proteins and their annotated locations for XP_006234144.1

      UniProtKB/TrEMBL
      A6JET3, D3ZG35
      Related
      ENSRNOP00000101964.1, ENSRNOT00000144886.1
      Conserved Domains (5) summary
      COG5236
      Location:269 → 381
      COG5236; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]
      sd00017
      Location:300 → 320
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cd18214
      Location:8 → 129
      BTB_POZ_ZBTB26_Bioref; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 26 (ZBTB26)
      pfam00096
      Location:298 → 320
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:315 → 337
      zf-H2C2_2; Zinc-finger double domain

    2. XM_039105270.2 → XP_038961198.1  zinc finger and BTB domain-containing protein 26 isoform X1

      UniProtKB/TrEMBL
      A6JET3, D3ZG35
      Related
      ENSRNOP00000096920.1, ENSRNOT00000110572.2
      Conserved Domains (5) summary
      COG5236
      Location:269 → 381
      COG5236; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]
      sd00017
      Location:300 → 320
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cd18214
      Location:8 → 129
      BTB_POZ_ZBTB26_Bioref; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 26 (ZBTB26)
      pfam00096
      Location:298 → 320
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:315 → 337
      zf-H2C2_2; Zinc-finger double domain

    3. XM_039105271.2 → XP_038961199.1  zinc finger and BTB domain-containing protein 26 isoform X1

      UniProtKB/TrEMBL
      A6JET3, D3ZG35
      Conserved Domains (5) summary
      COG5236
      Location:269 → 381
      COG5236; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]
      sd00017
      Location:300 → 320
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cd18214
      Location:8 → 129
      BTB_POZ_ZBTB26_Bioref; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 26 (ZBTB26)
      pfam00096
      Location:298 → 320
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:315 → 337
      zf-H2C2_2; Zinc-finger double domain

    4. XM_039105272.2 → XP_038961200.1  zinc finger and BTB domain-containing protein 26 isoform X1

      UniProtKB/TrEMBL
      A6JET3, D3ZG35
      Conserved Domains (5) summary
      COG5236
      Location:269 → 381
      COG5236; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]
      sd00017
      Location:300 → 320
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cd18214
      Location:8 → 129
      BTB_POZ_ZBTB26_Bioref; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 26 (ZBTB26)
      pfam00096
      Location:298 → 320
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:315 → 337
      zf-H2C2_2; Zinc-finger double domain
    Nucleotide Protein Strain
    Heading Accession and Version

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