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    Mx1 MX dynamin like GTPase 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 24575, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Mx1provided by RGD
    Official Full Name
    MX dynamin like GTPase 1provided by RGD
    Primary source
    RGD:3127
    See related
    EnsemblRapid:ENSRNOG00000001959 AllianceGenome:RGD:3127
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    IFI78
    Summary
    Predicted to enable GTPase activity; identical protein binding activity; and microtubule binding activity. Involved in response to virus. Located in nucleus. Human ortholog(s) of this gene implicated in alopecia areata; avian influenza; liver disease; and prostate cancer. Orthologous to human MX1 (MX dynamin like GTPase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 356.1), Thymus (RPKM 152.3) and 6 other tissues See more
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    Genomic context

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    See Mx1 in Genome Data Viewer
    Location:
    11q12
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (50269056..50294699, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (36799659..36825209, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (37891150..37916775, complement)

    Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene DS cell adhesion molecule Neighboring gene uncharacterized LOC120095544 Neighboring gene beta-secretase 2 Neighboring gene FAM3 metabolism regulating signaling molecule B Neighboring gene MX dynamin like GTPase 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Influenza restriction factor MxA functions as inflammasome sensor in the respiratory epithelium. Lee S, et al. Sci Immunol, 2019 Oct 25. PMID 31653718
    2. Resistance to influenza virus infection of Mx transgenic mice expressing Mx protein under the control of two constitutive promoters. Kolb E, et al. J Virol, 1992 Mar. PMID 1371172, Free PMC Article
    3. Aetiology of febrile pharyngitis in children: Potential of myxovirus resistance protein A (MxA) as a biomarker of viral infection. Ivaska L, et al. J Infect, 2017 Apr. PMID 28077283, Free PMC Article
    4. In vivo evasion of MxA by avian influenza viruses requires human signature in the viral nucleoprotein. Deeg CM, et al. J Exp Med, 2017 May 1. PMID 28396461, Free PMC Article
    5. Plasmacytoid dendritic cells and type I interferon in the immunological response against warts. Saadeh D, et al. Clin Exp Dermatol, 2017 Dec. PMID 28736973

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Six differentially expressed genes (Kcne1, Rcan1, Mx1, Mx2, Tmprss2, and RGD1559516) were identified in the renal cortex, and three genes (Rcan1, Mx2, and Tmprss2) were identified in the renal medulla.
      Title: [Differentially expressed genes in the locus associated with relative kidney weight and resting blood pressure in hypertensive rats of the ISIAH strain].
    2. IFN treatment induced Mx production and increased PKR production in immature germ cells
      Title: Production of the antiviral proteins 2'5'oligoadenylate synthetase, PKR and Mx in interstitial cells and spermatogonia.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in defense response to virus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in innate immune response ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in interleukin-27-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of viral genome replication ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in receptor internalization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in response to virus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in response to virus IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to virus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in synaptic vesicle budding from presynaptic endocytic zone membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nuclear membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in synapse IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    interferon-induced GTP-binding protein Mx1
    Names
    Myxovirus (influenza) resistance, homolog of murine Mx (also interferon-inducible protein IFI78)
    myxoma resistance protein 1
    myxovirus (influenza virus) resistance 1
    myxovirus resistance protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001271058.1 → NP_001257987.1  interferon-induced GTP-binding protein Mx1

      See identical proteins and their annotated locations for NP_001257987.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. All six variants encode the same protein.
      Source sequence(s)
      BC099784, JAXUCZ010000011
      UniProtKB/Swiss-Prot
      P18588
      UniProtKB/TrEMBL
      F7EXA4, Q499S4
      Conserved Domains (3) summary
      smart00302
      Location:559 → 650
      GED; Dynamin GTPase effector domain
      cd08771
      Location:59 → 331
      DLP_1; Dynamin_like protein family includes dynamins and Mx proteins
      pfam01031
      Location:251 → 540
      Dynamin_M; Dynamin central region

    2. NM_001271059.1 → NP_001257988.1  interferon-induced GTP-binding protein Mx1

      See identical proteins and their annotated locations for NP_001257988.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. All six variants encode the same protein.
      Source sequence(s)
      BC099784, JAXUCZ010000011
      UniProtKB/Swiss-Prot
      P18588
      UniProtKB/TrEMBL
      F7EXA4, Q499S4
      Conserved Domains (3) summary
      smart00302
      Location:559 → 650
      GED; Dynamin GTPase effector domain
      cd08771
      Location:59 → 331
      DLP_1; Dynamin_like protein family includes dynamins and Mx proteins
      pfam01031
      Location:251 → 540
      Dynamin_M; Dynamin central region

    3. NM_001271060.1 → NP_001257989.1  interferon-induced GTP-binding protein Mx1

      See identical proteins and their annotated locations for NP_001257989.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. All six variants encode the same protein.
      Source sequence(s)
      BC099784, JAXUCZ010000011
      UniProtKB/Swiss-Prot
      P18588
      UniProtKB/TrEMBL
      F7EXA4, Q499S4
      Conserved Domains (3) summary
      smart00302
      Location:559 → 650
      GED; Dynamin GTPase effector domain
      cd08771
      Location:59 → 331
      DLP_1; Dynamin_like protein family includes dynamins and Mx proteins
      pfam01031
      Location:251 → 540
      Dynamin_M; Dynamin central region

    4. NM_001271061.1 → NP_001257990.1  interferon-induced GTP-binding protein Mx1

      See identical proteins and their annotated locations for NP_001257990.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. All six variants encode the same protein.
      Source sequence(s)
      BC099784, JAXUCZ010000011
      UniProtKB/Swiss-Prot
      P18588
      UniProtKB/TrEMBL
      F7EXA4, Q499S4
      Conserved Domains (3) summary
      smart00302
      Location:559 → 650
      GED; Dynamin GTPase effector domain
      cd08771
      Location:59 → 331
      DLP_1; Dynamin_like protein family includes dynamins and Mx proteins
      pfam01031
      Location:251 → 540
      Dynamin_M; Dynamin central region

    5. NM_001271062.1 → NP_001257991.1  interferon-induced GTP-binding protein Mx1

      See identical proteins and their annotated locations for NP_001257991.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR compared to variant 1. All six variants encode the same protein.
      Source sequence(s)
      BC099784, JAXUCZ010000011
      UniProtKB/Swiss-Prot
      P18588
      UniProtKB/TrEMBL
      F7EXA4, Q499S4
      Conserved Domains (3) summary
      smart00302
      Location:559 → 650
      GED; Dynamin GTPase effector domain
      cd08771
      Location:59 → 331
      DLP_1; Dynamin_like protein family includes dynamins and Mx proteins
      pfam01031
      Location:251 → 540
      Dynamin_M; Dynamin central region

    6. NM_173096.3 → NP_775119.2  interferon-induced GTP-binding protein Mx1

      See identical proteins and their annotated locations for NP_775119.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. All six variants encode the same protein.
      Source sequence(s)
      BC099784, JAXUCZ010000011
      UniProtKB/Swiss-Prot
      P18588
      UniProtKB/TrEMBL
      F7EXA4, Q499S4
      Related
      ENSRNOP00000043001.3, ENSRNOT00000039876.7
      Conserved Domains (3) summary
      smart00302
      Location:559 → 650
      GED; Dynamin GTPase effector domain
      cd08771
      Location:59 → 331
      DLP_1; Dynamin_like protein family includes dynamins and Mx proteins
      pfam01031
      Location:251 → 540
      Dynamin_M; Dynamin central region

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086029.1 Reference GRCr8

      Range
      50269056..50294699 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017597877.3 → XP_017453366.1  interferon-induced GTP-binding protein Mx1 isoform X1

      UniProtKB/Swiss-Prot
      P18588
      UniProtKB/TrEMBL
      F7EXA4, Q499S4
      Conserved Domains (3) summary
      smart00302
      Location:559 → 650
      GED; Dynamin GTPase effector domain
      cd08771
      Location:59 → 331
      DLP_1; Dynamin_like protein family includes dynamins and Mx proteins
      pfam01031
      Location:251 → 540
      Dynamin_M; Dynamin central region

    2. XM_006248146.5 → XP_006248208.1  interferon-induced GTP-binding protein Mx1 isoform X1

      See identical proteins and their annotated locations for XP_006248208.1

      UniProtKB/Swiss-Prot
      P18588
      UniProtKB/TrEMBL
      F7EXA4, Q499S4
      Conserved Domains (3) summary
      smart00302
      Location:559 → 650
      GED; Dynamin GTPase effector domain
      cd08771
      Location:59 → 331
      DLP_1; Dynamin_like protein family includes dynamins and Mx proteins
      pfam01031
      Location:251 → 540
      Dynamin_M; Dynamin central region

    3. XM_063270276.1 → XP_063126346.1  interferon-induced GTP-binding protein Mx1 isoform X1

      UniProtKB/Swiss-Prot
      P18588
      UniProtKB/TrEMBL
      F7EXA4, Q499S4

    4. XM_039087955.2 → XP_038943883.1  interferon-induced GTP-binding protein Mx1 isoform X1

      UniProtKB/Swiss-Prot
      P18588
      UniProtKB/TrEMBL
      F7EXA4, Q499S4
      Conserved Domains (3) summary
      smart00302
      Location:559 → 650
      GED; Dynamin GTPase effector domain
      cd08771
      Location:59 → 331
      DLP_1; Dynamin_like protein family includes dynamins and Mx proteins
      pfam01031
      Location:251 → 540
      Dynamin_M; Dynamin central region

    5. XM_017597878.3 → XP_017453367.1  interferon-induced GTP-binding protein Mx1 isoform X1

      UniProtKB/Swiss-Prot
      P18588
      UniProtKB/TrEMBL
      F7EXA4, Q499S4
      Conserved Domains (3) summary
      smart00302
      Location:559 → 650
      GED; Dynamin GTPase effector domain
      cd08771
      Location:59 → 331
      DLP_1; Dynamin_like protein family includes dynamins and Mx proteins
      pfam01031
      Location:251 → 540
      Dynamin_M; Dynamin central region

    6. XM_039087956.2 → XP_038943884.1  interferon-induced GTP-binding protein Mx1 isoform X1

      UniProtKB/Swiss-Prot
      P18588
      UniProtKB/TrEMBL
      F7EXA4, Q499S4
      Conserved Domains (3) summary
      smart00302
      Location:559 → 650
      GED; Dynamin GTPase effector domain
      cd08771
      Location:59 → 331
      DLP_1; Dynamin_like protein family includes dynamins and Mx proteins
      pfam01031
      Location:251 → 540
      Dynamin_M; Dynamin central region
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P18588.1 GenPept UniProtKB/Swiss-Prot:P18588

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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