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    Tlr5 toll-like receptor 5 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 289337, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Tlr5provided by RGD
    Official Full Name
    toll-like receptor 5provided by RGD
    Primary source
    RGD:631351
    See related
    EnsemblRapid:ENSRNOG00000022067 AllianceGenome:RGD:631351
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable interleukin-1 receptor binding activity and pattern recognition receptor activity. Involved in cellular response to lipopolysaccharide; male gonad development; and positive regulation of nitric oxide biosynthetic process. Predicted to be active in plasma membrane. Biomarker of perinatal necrotizing enterocolitis. Human ortholog(s) of this gene implicated in Legionnaires' disease; cystic fibrosis; cystitis; melioidosis; and systemic lupus erythematosus. Orthologous to human TLR5 (toll like receptor 5). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 54.3), Lung (RPKM 17.3) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Tlr5 in Genome Data Viewer
    Location:
    13q26
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (97166430..97190642)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (94634778..94658992)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (101364784..101385764)

    Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORD113/SNORD114 family Neighboring gene ubiquitin A-52 residue ribosomal protein fusion product 1, pseudogene 19 Neighboring gene dispatched RND transporter family member 1 Neighboring gene uncharacterized LOC108352652

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Effects of mannoprotein E1 in liquid diet on inflammatory response and TLR5 expression in the gut of rats infected by Salmonella typhimurium. Posadas SJ, et al. BMC Gastroenterol, 2010 Jun 8. PMID 20529359, Free PMC Article
    2. Bacterial flagellin triggers cardiac innate immune responses and acute contractile dysfunction. Rolli J, et al. PLoS One, 2010 Sep 13. PMID 20856884, Free PMC Article
    3. Gene expression of Toll-like receptors and associated molecules induced by inflammatory stimuli in the primary alveolar macrophage. Oshikawa K, et al. Biochem Biophys Res Commun, 2003 Jun 6. PMID 12763043
    4. Toll-like receptor signaling stimulates cell cycle entry and progression in fibroblasts. Hasan UA, et al. J Biol Chem, 2005 May 27. PMID 15788393
    5. Glucose activation of islets of Langerhans up-regulates Toll-like receptor 5: possible mechanism of protection. Weile C, et al. Clin Exp Immunol, 2011 Nov. PMID 21985371, Free PMC Article

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Exosomal microRNA-150-5p from bone marrow mesenchymal stromal cells mitigates cerebral ischemia/reperfusion injury via targeting toll-like receptor 5.
      Title: Exosomal microRNA-150-5p from bone marrow mesenchymal stromal cells mitigates cerebral ischemia/reperfusion injury via targeting toll-like receptor 5.
    2. Toll-like receptor 5 deficiency diminishes doxorubicin-induced acute cardiotoxicity in mice.
      Title: Toll-like receptor 5 deficiency diminishes doxorubicin-induced acute cardiotoxicity in mice.
    3. Cross-Talk of Toll-Like Receptor 5 and Mu-Opioid Receptor Attenuates Chronic Constriction Injury-Induced Mechanical Hyperalgesia through a Protein Kinase C Alpha-Dependent Signaling.
      Title: Cross-Talk of Toll-Like Receptor 5 and Mu-Opioid Receptor Attenuates Chronic Constriction Injury-Induced Mechanical Hyperalgesia through a Protein Kinase C Alpha-Dependent Signaling.
    4. Results suggest that TLR5 is a potential target gene of miR-150. TLR5 seems to negatively regulate miR-150 in vitro.
      Title: MiR-150 alleviates neuropathic pain via inhibiting toll-like receptor 5.
    5. These results suggest that HMGB1-modulated TLR5 signaling is responsible for pain hypersensitivity.
      Title: HMGB1 Activates Proinflammatory Signaling via TLR5 Leading to Allodynia.
    6. aortic angiogenesis is preceded by an immune reaction with overexpression of Toll-like receptors (TLRs) and TLR-inducible genes.
      Title: Regulation of angiogenesis, mural cell recruitment and adventitial macrophage behavior by Toll-like receptors.
    7. study found glucose up-regulates TLR-5 in islet cells, and that TLR-5 activation reduces insulin secretion, increases the level of heat-shock protein and increases MHC class I transport for presentation.
      Title: Glucose activation of islets of Langerhans up-regulates Toll-like receptor 5: possible mechanism of protection.
    8. toll-like receptors and nucleotide-binding oligomerization domain 2 combinations are contributors to the signaling cascades resulting in purinergic microglial activation
      Title: Combinations of TLR and NOD2 ligands stimulate rat microglial P2X4R expression.
    9. PSCs expressed a variety of TLRs and responded to TLR ligands, leading to the activation of signaling pathways and proinflammatory responses.
      Title: Pancreatic stellate cells express Toll-like receptors.
    10. data provide evidence for a nonimmune and cell autonomous role of Toll-like receptor 5 (TLR5) signaling, whereby TLR5 stimulation provides a positive signal for cell division
      Title: Toll-like receptor signaling stimulates cell cycle entry and progression in fibroblasts.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables interleukin-1 receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables pattern recognition receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables signaling receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transmembrane signaling receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to lipopolysaccharide IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in cellular response to mechanical stimulus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in inflammatory response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in innate immune response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in male gonad development IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of positive regulation of interleukin-8 production ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of nitric oxide biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of tumor necrosis factor production IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in toll-like receptor 5 signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in toll-like receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    toll-like receptor 5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001145828.1 → NP_001139300.1  toll-like receptor 5

      See identical proteins and their annotated locations for NP_001139300.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473985
      UniProtKB/TrEMBL
      A6JGM7, G3V6F8
      Conserved Domains (6) summary
      TIGR00864
      Location:567 → 645
      PCC; polycystin cation channel protein
      PLN00113
      Location:108 → 384
      PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
      COG4886
      Location:314 → 578
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00033
      Location:302 → 325
      LRR_RI; leucine-rich repeat [structural motif]
      pfam01582
      Location:706 → 856
      TIR; TIR domain
      pfam13855
      Location:326 → 384
      LRR_8; Leucine rich repeat

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086031.1 Reference GRCr8

      Range
      97166430..97190642
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063272173.1 → XP_063128243.1  toll-like receptor 5 isoform X1

      UniProtKB/TrEMBL
      A6JGM7, G3V6F8
      Related
      ENSRNOP00000092561.1, ENSRNOT00000109851.2

    2. XM_039090570.2 → XP_038946498.1  toll-like receptor 5 isoform X1

      UniProtKB/TrEMBL
      A6JGM7, G3V6F8
      Related
      ENSRNOP00000107039.1, ENSRNOT00000127807.1
      Conserved Domains (6) summary
      TIGR00864
      Location:567 → 645
      PCC; polycystin cation channel protein
      PLN00113
      Location:108 → 384
      PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
      COG4886
      Location:314 → 578
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00033
      Location:302 → 325
      LRR_RI; leucine-rich repeat [structural motif]
      pfam01582
      Location:706 → 856
      TIR; TIR domain
      pfam13855
      Location:326 → 384
      LRR_8; Leucine rich repeat

    3. XM_039090569.2 → XP_038946497.1  toll-like receptor 5 isoform X1

      UniProtKB/TrEMBL
      A6JGM7, G3V6F8
      Related
      ENSRNOP00000102645.1, ENSRNOT00000145129.1
      Conserved Domains (6) summary
      TIGR00864
      Location:567 → 645
      PCC; polycystin cation channel protein
      PLN00113
      Location:108 → 384
      PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
      COG4886
      Location:314 → 578
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00033
      Location:302 → 325
      LRR_RI; leucine-rich repeat [structural motif]
      pfam01582
      Location:706 → 856
      TIR; TIR domain
      pfam13855
      Location:326 → 384
      LRR_8; Leucine rich repeat

    4. XM_039090571.2 → XP_038946499.1  toll-like receptor 5 isoform X2

      UniProtKB/TrEMBL
      C0LP03
      Related
      ENSRNOP00000086526.1, ENSRNOT00000107238.2
      Conserved Domains (6) summary
      TIGR00864
      Location:555 → 633
      PCC; polycystin cation channel protein
      PLN00113
      Location:96 → 372
      PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
      COG4886
      Location:302 → 566
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00033
      Location:290 → 313
      LRR_RI; leucine-rich repeat [structural motif]
      pfam01582
      Location:694 → 844
      TIR; TIR domain
      pfam13855
      Location:314 → 372
      LRR_8; Leucine rich repeat

    5. XM_039090568.2 → XP_038946496.1  toll-like receptor 5 isoform X1

      UniProtKB/TrEMBL
      A6JGM7, G3V6F8
      Related
      ENSRNOP00000107919.1, ENSRNOT00000136113.1
      Conserved Domains (6) summary
      TIGR00864
      Location:567 → 645
      PCC; polycystin cation channel protein
      PLN00113
      Location:108 → 384
      PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
      COG4886
      Location:314 → 578
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00033
      Location:302 → 325
      LRR_RI; leucine-rich repeat [structural motif]
      pfam01582
      Location:706 → 856
      TIR; TIR domain
      pfam13855
      Location:326 → 384
      LRR_8; Leucine rich repeat

    6. XM_039090572.2 → XP_038946500.1  toll-like receptor 5 isoform X2

      UniProtKB/TrEMBL
      C0LP03
      Conserved Domains (6) summary
      TIGR00864
      Location:555 → 633
      PCC; polycystin cation channel protein
      PLN00113
      Location:96 → 372
      PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
      COG4886
      Location:302 → 566
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00033
      Location:290 → 313
      LRR_RI; leucine-rich repeat [structural motif]
      pfam01582
      Location:694 → 844
      TIR; TIR domain
      pfam13855
      Location:314 → 372
      LRR_8; Leucine rich repeat

    RNA

    1. XR_005492227.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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