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    Grin2b glutamate ionotropic receptor NMDA type subunit 2B [ Rattus norvegicus (Norway rat) ]

    Gene ID: 24410, updated on 10-Dec-2024

    Summary

    Official Symbol
    Grin2bprovided by RGD
    Official Full Name
    glutamate ionotropic receptor NMDA type subunit 2Bprovided by RGD
    Primary source
    RGD:2738
    See related
    EnsemblRapid:ENSRNOG00000008766 AllianceGenome:RGD:2738
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    GluN2B
    Summary
    Enables several functions, including beta-catenin binding activity; extracellular ligand-gated monoatomic ion channel activity; and signaling receptor binding activity. Involved in several processes, including cellular response to ketone; learning or memory; and modulation of chemical synaptic transmission. Located in several cellular components, including dendrite; postsynaptic density, intracellular component; and synaptic cleft. Part of NMDA selective glutamate receptor complex. Is active in several cellular components, including hippocampal mossy fiber to CA3 synapse; parallel fiber to Purkinje cell synapse; and synaptic membrane. Used to study attention deficit hyperactivity disorder; fetal alcohol spectrum disorder; hyperhomocysteinemia; and transient cerebral ischemia. Biomarker of several diseases, including attention deficit hyperactivity disorder; cognitive disorder (multiple); egg allergy; placental insufficiency; and sciatic neuropathy. Human ortholog(s) of this gene implicated in several diseases, including alcohol use disorder; autosomal dominant intellectual developmental disorder 6; developmental and epileptic encephalopathy 27; neurodegenerative disease (multiple); and nicotine dependence. Orthologous to human GRIN2B (glutamate ionotropic receptor NMDA type subunit 2B). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward (RPKM 321.7) See more
    Orthologs
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    Genomic context

    See Grin2b in Genome Data Viewer
    Location:
    4q43
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (170297811..170775420, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (168580824..169044110, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (169541620..170000216, complement)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134486686 Neighboring gene small nucleolar RNA SNORA36 family Neighboring gene uncharacterized LOC120102418 Neighboring gene RNA, U2 small nuclear 63 Neighboring gene zinc finger protein 84-like

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by RGD

    Items 1 - 25 of 34
    Function Evidence Code Pubs
    enables D2 dopamine receptor binding PubMed 
    enables NMDA glutamate receptor activity  
    enables NMDA glutamate receptor activity PubMed 
    enables NMDA glutamate receptor activity  
    enables NMDA glutamate receptor activity  
    enables beta-catenin binding PubMed 
    enables calcium channel activity  
    enables cell adhesion molecule binding PubMed 
    enables extracellularly glutamate-gated ion channel activity PubMed 
    enables glutamate binding PubMed 
    enables glutamate receptor binding PubMed 
    enables glutamate-gated calcium ion channel activity  
    enables glutamate-gated calcium ion channel activity  
    enables glutamate-gated calcium ion channel activity  
    enables glutamate-gated receptor activity PubMed 
    enables glycine binding  
    enables glycine binding  
    enables heterocyclic compound binding PubMed 
    enables interleukin-1 receptor binding PubMed 
    enables ionotropic glutamate receptor binding PubMed 
    enables ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential  
    enables ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential  
    enables metal ion binding  
    enables monoatomic cation channel activity  
    enables protein binding PubMed 
    enables protein tyrosine kinase binding PubMed 
    enables protein-containing complex binding PubMed 
    enables scaffold protein binding PubMed 
    enables signaling receptor binding PubMed 
    enables small molecule binding PubMed 
    enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential  
    enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential PubMed 
    enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential PubMed 
    enables zinc ion binding PubMed 
    Items 1 - 25 of 34
    Items 1 - 25 of 96
    Process Evidence Code Pubs
    involved_in action potential PubMed 
    involved_in associative learning PubMed 
    involved_in auditory behavior PubMed 
    involved_in behavioral fear response PubMed 
    acts_upstream_of_or_within behavioral fear response  
    acts_upstream_of_or_within behavioral response to pain  
    involved_in calcium ion transmembrane import into cytosol  
    involved_in calcium ion transmembrane import into cytosol  
    involved_in calcium ion transmembrane import into cytosol  
    acts_upstream_of_or_within calcium ion transport  
    involved_in calcium-mediated signaling  
    involved_in cellular response to amino acid stimulus PubMed 
    involved_in cellular response to corticosterone stimulus PubMed 
    involved_in cellular response to curcumin PubMed 
    involved_in cellular response to dsRNA PubMed 
    involved_in cellular response to forskolin PubMed 
    involved_in cellular response to growth factor stimulus PubMed 
    involved_in cellular response to lipid PubMed 
    involved_in cellular response to magnesium starvation PubMed 
    involved_in cellular response to manganese ion PubMed 
    involved_in cellular response to organic cyclic compound PubMed 
    involved_in cerebral cortex development PubMed 
    acts_upstream_of_or_within chemical synaptic transmission  
    acts_upstream_of_or_within detection of mechanical stimulus involved in sensory perception of pain  
    involved_in excitatory postsynaptic potential  
    acts_upstream_of_or_within excitatory postsynaptic potential  
    acts_upstream_of_or_within fear response  
    involved_in hippocampus development PubMed 
    acts_upstream_of_or_within in utero embryonic development  
    involved_in intracellular calcium ion homeostasis PubMed 
    involved_in ionotropic glutamate receptor signaling pathway PubMed 
    involved_in ionotropic glutamate receptor signaling pathway  
    involved_in ionotropic glutamate receptor signaling pathway  
    acts_upstream_of_or_within learning  
    involved_in learning or memory PubMed 
    involved_in learning or memory PubMed 
    involved_in long-term memory PubMed 
    involved_in long-term synaptic potentiation  
    involved_in long-term synaptic potentiation PubMed 
    acts_upstream_of_or_within long-term synaptic potentiation  
    involved_in memory PubMed 
    acts_upstream_of_or_within memory  
    involved_in monoatomic cation transmembrane transport  
    involved_in monoatomic cation transmembrane transport  
    acts_upstream_of_or_within monoatomic cation transport  
    involved_in multicellular organismal response to stress PubMed 
    involved_in negative regulation of dendritic spine maintenance  
    involved_in neuron development PubMed 
    involved_in positive regulation of excitatory postsynaptic potential PubMed 
    involved_in positive regulation of excitatory postsynaptic potential PubMed 
    involved_in positive regulation of excitatory postsynaptic potential  
    involved_in positive regulation of glutamate secretion PubMed 
    involved_in positive regulation of inhibitory postsynaptic potential PubMed 
    involved_in positive regulation of synaptic transmission, glutamatergic PubMed 
    involved_in positive regulation of synaptic transmission, glutamatergic  
    involved_in protein heterotetramerization PubMed 
    involved_in receptor clustering PubMed 
    involved_in regulation of ARF protein signal transduction PubMed 
    involved_in regulation of MAPK cascade PubMed 
    acts_upstream_of_or_within regulation of cAMP/PKA signal transduction  
    involved_in regulation of long-term neuronal synaptic plasticity PubMed 
    involved_in regulation of monoatomic cation transmembrane transport  
    involved_in regulation of neuronal synaptic plasticity PubMed 
    acts_upstream_of_or_within regulation of postsynaptic membrane potential  
    involved_in regulation of presynaptic membrane potential  
    acts_upstream_of_or_within regulation of synaptic plasticity  
    involved_in response to amine PubMed 
    involved_in response to amphetamine PubMed 
    involved_in response to calcium ion PubMed 
    involved_in response to carbohydrate PubMed 
    involved_in response to cocaine PubMed 
    involved_in response to cytokine PubMed 
    involved_in response to electrical stimulus PubMed 
    involved_in response to ethanol  
    involved_in response to ethanol PubMed 
    acts_upstream_of_or_within response to ethanol  
    involved_in response to ethanol  
    involved_in response to fungicide PubMed 
    involved_in response to growth hormone PubMed 
    involved_in response to hydrogen sulfide PubMed 
    involved_in response to hypoxia PubMed 
    involved_in response to lead ion PubMed 
    involved_in response to magnesium ion PubMed 
    involved_in response to manganese ion PubMed 
    involved_in response to mechanical stimulus PubMed 
    involved_in response to methylmercury PubMed 
    involved_in response to nicotine PubMed 
    involved_in response to organic cyclic compound PubMed 
    involved_in response to other organism PubMed 
    involved_in response to toxic substance PubMed 
    involved_in rhythmic process PubMed 
    involved_in sensitization PubMed 
    acts_upstream_of_or_within sensory organ development  
    acts_upstream_of_or_within startle response  
    acts_upstream_of_or_within suckling behavior  
    involved_in synaptic transmission, glutamatergic  
    Items 1 - 25 of 96
    Items 1 - 20 of 56
    Component Evidence Code Pubs
    part_of NMDA selective glutamate receptor complex  
    part_of NMDA selective glutamate receptor complex PubMed 
    part_of NMDA selective glutamate receptor complex  
    part_of NMDA selective glutamate receptor complex  
    part_of NMDA selective glutamate receptor complex  
    located_in Z disc PubMed 
    located_in apical dendrite PubMed 
    located_in cell surface PubMed 
    located_in cell surface  
    located_in cytoplasm PubMed 
    located_in cytoskeleton  
    located_in dendritic branch PubMed 
    located_in dendritic spine PubMed 
    located_in endoplasmic reticulum membrane  
    is_active_in glutamatergic synapse PubMed 
    is_active_in glutamatergic synapse PubMed 
    is_active_in glutamatergic synapse  
    is_active_in hippocampal mossy fiber to CA3 synapse PubMed 
    located_in late endosome  
    located_in late endosome  
    located_in lysosome  
    located_in lysosome  
    located_in membrane  
    located_in membrane  
    located_in neuron projection PubMed 
    located_in neuron projection  
    located_in neuronal cell body PubMed 
    is_active_in parallel fiber to Purkinje cell synapse PubMed 
    is_active_in plasma membrane  
    located_in plasma membrane PubMed 
    located_in plasma membrane  
    located_in plasma membrane  
    located_in plasma membrane  
    located_in postsynapse  
    located_in postsynaptic density PubMed 
    is_active_in postsynaptic density  
    located_in postsynaptic density  
    is_active_in postsynaptic density membrane  
    is_active_in postsynaptic density membrane PubMed 
    is_active_in postsynaptic density membrane  
    located_in postsynaptic density, intracellular component PubMed 
    located_in postsynaptic membrane PubMed 
    located_in postsynaptic membrane  
    located_in postsynaptic membrane  
    located_in postsynaptic membrane PubMed 
    is_active_in presynaptic active zone membrane PubMed 
    is_active_in presynaptic membrane PubMed 
    located_in presynaptic membrane PubMed 
    located_in presynaptic membrane  
    located_in synapse PubMed 
    located_in synapse  
    located_in synapse PubMed 
    located_in synaptic cleft PubMed 
    located_in synaptic membrane  
    located_in synaptic vesicle  
    located_in terminal bouton PubMed 
    Items 1 - 20 of 56

    General protein information

    Preferred Names
    glutamate receptor ionotropic, NMDA 2B
    Names
    N-methyl D-aspartate receptor subtype 2B
    NMDAR2B
    NR2B
    glutamate [NMDA] receptor subunit epsilon-2
    glutamate receptor, ionotropic, N-methyl D-aspartate 2B
    glutamate receptor, ionotropic, NMDA2B

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_012574.1NP_036706.1  glutamate receptor ionotropic, NMDA 2B precursor

      See identical proteins and their annotated locations for NP_036706.1

      Status: PROVISIONAL

      Source sequence(s)
      U11419
      UniProtKB/Swiss-Prot
      Q00960, Q62684
      Related
      ENSRNOP00000011697.3, ENSRNOT00000011697.6
      Conserved Domains (5) summary
      cd06378
      Location:33393
      PBP1_iGluR_NMDA_NR2; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the NR2 subunit of NMDA receptor family
      COG0834
      Location:459542
      HisJ; ABC-type amino acid transport/signal transduction system, periplasmic component/domain [Amino acid transport and metabolism, Signal transduction mechanisms]
      cd13718
      Location:403803
      PBP2_iGluR_NMDA_Nr2; The ligand-binding domain of the NR2 subunit of ionotropic NMDA (N-methyl-D-aspartate) glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
      pfam00060
      Location:557829
      Lig_chan; Ligand-gated ion channel
      pfam10565
      Location:8401482
      NMDAR2_C; N-methyl D-aspartate receptor 2B3 C-terminus

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      170297811..170775420 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017592437.3XP_017447926.1  glutamate receptor ionotropic, NMDA 2B isoform X1

      UniProtKB/Swiss-Prot
      Q00960, Q62684
      UniProtKB/TrEMBL
      A6IMH0, G3V746
      Conserved Domains (5) summary
      cd06378
      Location:33393
      PBP1_iGluR_NMDA_NR2; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the NR2 subunit of NMDA receptor family
      COG0834
      Location:459542
      HisJ; ABC-type amino acid transport/signal transduction system, periplasmic component/domain [Amino acid transport and metabolism, Signal transduction mechanisms]
      cd13718
      Location:403803
      PBP2_iGluR_NMDA_Nr2; The ligand-binding domain of the NR2 subunit of ionotropic NMDA (N-methyl-D-aspartate) glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
      pfam00060
      Location:557829
      Lig_chan; Ligand-gated ion channel
      pfam10565
      Location:8401482
      NMDAR2_C; N-methyl D-aspartate receptor 2B3 C-terminus
    2. XM_017592438.3XP_017447927.1  glutamate receptor ionotropic, NMDA 2B isoform X1

      UniProtKB/Swiss-Prot
      Q00960, Q62684
      UniProtKB/TrEMBL
      A6IMH0, G3V746
      Conserved Domains (5) summary
      cd06378
      Location:33393
      PBP1_iGluR_NMDA_NR2; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the NR2 subunit of NMDA receptor family
      COG0834
      Location:459542
      HisJ; ABC-type amino acid transport/signal transduction system, periplasmic component/domain [Amino acid transport and metabolism, Signal transduction mechanisms]
      cd13718
      Location:403803
      PBP2_iGluR_NMDA_Nr2; The ligand-binding domain of the NR2 subunit of ionotropic NMDA (N-methyl-D-aspartate) glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
      pfam00060
      Location:557829
      Lig_chan; Ligand-gated ion channel
      pfam10565
      Location:8401482
      NMDAR2_C; N-methyl D-aspartate receptor 2B3 C-terminus
    3. XM_017592439.3XP_017447928.1  glutamate receptor ionotropic, NMDA 2B isoform X2

      UniProtKB/Swiss-Prot
      Q00960, Q62684
      Related
      ENSRNOP00000102212.1, ENSRNOT00000159969.1
    4. XM_017592436.3XP_017447925.1  glutamate receptor ionotropic, NMDA 2B isoform X1

      UniProtKB/Swiss-Prot
      Q00960, Q62684
      UniProtKB/TrEMBL
      A6IMH0, G3V746
      Conserved Domains (5) summary
      cd06378
      Location:33393
      PBP1_iGluR_NMDA_NR2; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the NR2 subunit of NMDA receptor family
      COG0834
      Location:459542
      HisJ; ABC-type amino acid transport/signal transduction system, periplasmic component/domain [Amino acid transport and metabolism, Signal transduction mechanisms]
      cd13718
      Location:403803
      PBP2_iGluR_NMDA_Nr2; The ligand-binding domain of the NR2 subunit of ionotropic NMDA (N-methyl-D-aspartate) glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
      pfam00060
      Location:557829
      Lig_chan; Ligand-gated ion channel
      pfam10565
      Location:8401482
      NMDAR2_C; N-methyl D-aspartate receptor 2B3 C-terminus
    5. XM_063285520.1XP_063141590.1  glutamate receptor ionotropic, NMDA 2B isoform X1

      UniProtKB/Swiss-Prot
      Q00960, Q62684
      UniProtKB/TrEMBL
      A6IMH0, G3V746
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