RT1-CE2 RT1 class I, locus CE2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: RT1-CE2provided by RGD
Official Full Name: RT1 class I, locus CE2provided by RGD
Primary source: RGD:1598235
See related: AllianceGenome:RGD:1598235
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RT1-C/E2
Summary: Predicted to be involved in antigen processing and presentation of peptide antigen via MHC class I. Predicted to be located in lumenal side of endoplasmic reticulum membrane and phagocytic vesicle membrane. Predicted to be part of MHC class I protein complex. Human ortholog(s) of this gene implicated in several diseases, including Stevens-Johnson syndrome; asthma (multiple); autoimmune disease (multiple); eye disease (multiple); and inner ear disease (multiple). Orthologous to several human genes including HLA-B (major histocompatibility complex, class I, B); HLA-C (major histocompatibility complex, class I, C); and HLA-E (major histocompatibility complex, class I, E). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

Location:: 20p12

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	20	NC_086038.1 (3542984..3546753, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	20	NC_051355.1 (3538452..3541841, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	20	NC_005119.4 (4771960..4774886, complement)

Chromosome 20 - NC_086038.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

D20Wox4 (e-PCR)
- UniSTS:118079

D20Mgh3 (e-PCR)
- UniSTS:261235

Gene Ontology Provided by RGD

Process	Evidence Code	Pubs
involved_in antigen processing and presentation of peptide antigen via MHC class I	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of MHC class I protein complex	IEA Inferred from Electronic Annotation more info
located_in lumenal side of endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in phagocytic vesicle membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: RT1 class I, locus CE2

Names: MHC class I protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001008840.2 → NP_001008840.1 RT1 class I, locus CE2 precursor

See identical proteins and their annotated locations for NP_001008840.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000020

UniProtKB/TrEMBL

E9PTZ9, Q861Q3

Conserved Domains (2) summary

cd07698
Location:204 → 296

IgC_MHC_I_alpha3; Class I major histocompatibility complex (MHC) alpha chain immunoglobulin domain

pfam00129
Location:22 → 200

MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086038.1 Reference GRCr8

Range

3542984..3546753 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039098958.2 → XP_038954886.1 RT1 class I, locus CE2 isoform X2

UniProtKB/TrEMBL

A0A2P1NRX6, E9PTZ9

Conserved Domains (3) summary

pfam00129
Location:22 → 200

MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2

cd00096
Location:205 → 213

Ig; Ig strand A [structural motif]

cl11960
Location:202 → 296

Ig; Immunoglobulin domain
XM_063279387.1 → XP_063135457.1 RT1 class I, locus CE2 isoform X1

UniProtKB/TrEMBL

E9PTZ9