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    Timm10 translocase of inner mitochondrial membrane 10 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 64464, updated on 9-Dec-2024

    Summary

    Official Symbol
    Timm10provided by RGD
    Official Full Name
    translocase of inner mitochondrial membrane 10provided by RGD
    Primary source
    RGD:621741
    See related
    EnsemblRapid:ENSRNOG00000007883 AllianceGenome:RGD:621741
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Tim10
    Summary
    Predicted to enable membrane insertase activity; protein homodimerization activity; and protein-folding chaperone binding activity. Predicted to be involved in protein insertion into mitochondrial inner membrane. Predicted to be located in mitochondrial intermembrane space. Predicted to be part of TIM22 mitochondrial import inner membrane insertion complex and mitochondrial intermembrane space protein transporter complex. Predicted to be active in mitochondrial inner membrane. Orthologous to human TIMM10 (translocase of inner mitochondrial membrane 10). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 295.5), Muscle (RPKM 173.3) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Timm10 in Genome Data Viewer
    Location:
    3q24
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (90315048..90318613)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (69908397..69911943)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (72226563..72230087)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene ubiquitin-conjugating enzyme E2L 6 Neighboring gene smoothelin-like 1 Neighboring gene uncharacterized LOC120101592 Neighboring gene solute carrier family 43 member 1 Neighboring gene uncharacterized LOC102554396 Neighboring gene reticulon 4 receptor-like 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables membrane insertase activity  
    enables metal ion binding  
    enables protein homodimerization activity  
    enables protein-folding chaperone binding  
    Component Evidence Code Pubs
    part_of TIM22 mitochondrial import inner membrane insertion complex  
    is_active_in mitochondrial inner membrane  
    located_in mitochondrial inner membrane  
    located_in mitochondrial intermembrane space  
    part_of mitochondrial intermembrane space protein transporter complex  
    located_in mitochondrion  

    General protein information

    Preferred Names
    mitochondrial import inner membrane translocase subunit Tim10
    Names
    small zinc finger-like protein
    translocase of inner mitochondrial membrane 10 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001431423.1NP_001418352.1  mitochondrial import inner membrane translocase subunit Tim10

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/Swiss-Prot
      P62074, Q5BKD3
      UniProtKB/TrEMBL
      A6HMR8
    2. NM_001431424.1NP_001418353.1  mitochondrial import inner membrane translocase subunit Tim10

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/Swiss-Prot
      P62074, Q5BKD3
      UniProtKB/TrEMBL
      A6HMR8
    3. NM_172074.4NP_742071.1  mitochondrial import inner membrane translocase subunit Tim10

      See identical proteins and their annotated locations for NP_742071.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/Swiss-Prot
      P62074, Q5BKD3
      UniProtKB/TrEMBL
      A6HMR8
      Conserved Domains (1) summary
      pfam02953
      Location:769
      zf-Tim10_DDP; Tim10/DDP family zinc finger

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      90315048..90318613
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006234473.5XP_006234535.1  mitochondrial import inner membrane translocase subunit Tim10 isoform X1

      Conserved Domains (1) summary
      pfam02953
      Location:769
      zf-Tim10_DDP; Tim10/DDP family zinc finger
    2. XM_006234474.5XP_006234536.1  mitochondrial import inner membrane translocase subunit Tim10 isoform X1

      Related
      ENSRNOP00000010619.3, ENSRNOT00000010619.6
      Conserved Domains (1) summary
      pfam02953
      Location:769
      zf-Tim10_DDP; Tim10/DDP family zinc finger
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