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    Pus10 pseudouridine synthase 10 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 305583, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Pus10provided by RGD
    Official Full Name
    pseudouridine synthase 10provided by RGD
    Primary source
    RGD:1306402
    See related
    EnsemblRapid:ENSRNOG00000054151 AllianceGenome:RGD:1306402
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1306402
    Summary
    Predicted to enable primary miRNA binding activity and tRNA pseudouridine synthase activity. Predicted to be involved in primary miRNA processing and tRNA pseudouridine synthesis. Predicted to be located in cytoplasm and nucleus. Orthologous to human PUS10 (pseudouridine synthase 10). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 81.4), Adrenal (RPKM 68.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Pus10 in Genome Data Viewer
    Location:
    14q22
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (101822525..101885187)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (97621228..97684059)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (108411941..108479696)

    Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene deoxycytidine kinase, pseudogene 1 Neighboring gene SANT and BTB domain regulator of CSR Neighboring gene peroxisomal biogenesis factor 13 Neighboring gene REL proto-oncogene, NF-kB subunit Neighboring gene uncharacterized LOC120096697

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Differential roles of human PUS10 in miRNA processing and tRNA pseudouridylation. Song J, et al. Nat Chem Biol, 2020 Feb. PMID 31819270
    2. The human ortholog of archaeal Pus10 produces pseudouridine 54 in select tRNAs where its recognition sequence contains a modified residue. Deogharia M, et al. RNA, 2019 Mar. PMID 30530625, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables primary miRNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables pseudouridine synthase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables pseudouridine synthase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables tRNA pseudouridine synthase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables tRNA pseudouridine(55) synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in primary miRNA processing ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in tRNA pseudouridine synthesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in tRNA pseudouridine synthesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    tRNA pseudouridine synthase Pus10
    Names
    pseudouridylate synthase 10
    putative tRNA pseudouridine synthase Pus10
    putative tRNA pseudouridine synthase Pus10-like
    NP_001020449.1
    NP_001388093.1
    XP_008768650.1
    XP_038948031.1
    XP_063129341.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001025278.2 → NP_001020449.1  tRNA pseudouridine synthase Pus10 isoform 2

      See identical proteins and their annotated locations for NP_001020449.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000014
      UniProtKB/TrEMBL
      G3V6R8, Q566D1

    2. NM_001401164.1 → NP_001388093.1  tRNA pseudouridine synthase Pus10 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000014
      UniProtKB/TrEMBL
      A0A0G2K0U8, A6JQ77
      Related
      ENSRNOP00000071589.3, ENSRNOT00000083763.3

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086032.1 Reference GRCr8

      Range
      101822525..101885187
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063273271.1 → XP_063129341.1  tRNA pseudouridine synthase Pus10 isoform X3

      UniProtKB/TrEMBL
      A0A0G2K0U8

    2. XM_008770428.4 → XP_008768650.1  tRNA pseudouridine synthase Pus10 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K0U8
      Conserved Domains (1) summary
      PRK14554
      Location:287 → 515
      PRK14554; putative pseudouridylate synthase; Provisional

    3. XM_039092103.2 → XP_038948031.1  tRNA pseudouridine synthase Pus10 isoform X2

      UniProtKB/TrEMBL
      A6JQ78
      Conserved Domains (1) summary
      cl28383
      Location:287 → 332
      Pus10; tRNA U54 and U55 pseudouridine synthase Pus10 [Translation, ribosomal structure and biogenesis]

    RNA

    1. XR_010057371.1 RNA Sequence

    2. XR_010057372.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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