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    Adam26a a disintegrin and metallopeptidase domain 26A [ Rattus norvegicus (Norway rat) ]

    Gene ID: 290763, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Adam26aprovided by RGD
    Official Full Name
    a disintegrin and metallopeptidase domain 26Aprovided by RGD
    Primary source
    RGD:1559501
    See related
    EnsemblRapid:ENSRNOG00000068728 AllianceGenome:RGD:1559501
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable metal ion binding activity and metalloendopeptidase activity. Predicted to be involved in proteolysis. Predicted to be located in membrane. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward (RPKM 79.6) See more
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    Genomic context

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    See Adam26a in Genome Data Viewer
    Location:
    16q12.1
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (55336354..55340765)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (48600998..48608314)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (51792060..51828519)

    Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene a disintegrin and metallopeptidase domain 34 Neighboring gene calcium binding and coiled-coil domain 2, pseudogene 1 Neighboring gene uncharacterized LOC134482382 Neighboring gene ATP synthase, H+ transporting, mitochondrial Fo complex, subunit d-like 1 Neighboring gene nuclear receptor co-repressor 1, pseudogene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metalloendopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metalloendopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in male gonad development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in sperm head plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    a disintegrin and metallopeptidase domain 26A
    Names
    testase 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001169119.1 → NP_001162590.1  a disintegrin and metallopeptidase domain 26A precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000016
      UniProtKB/TrEMBL
      A0A8I6A576, Q5U2M5
      Related
      ENSRNOP00000086380.1, ENSRNOT00000096374.2
      Conserved Domains (4) summary
      smart00608
      Location:491 → 626
      ACR; ADAM Cysteine-Rich Domain
      cd04269
      Location:208 → 396
      ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
      pfam00200
      Location:414 → 486
      Disintegrin
      pfam01562
      Location:42 → 160
      Pep_M12B_propep; Reprolysin family propeptide

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086034.1 Reference GRCr8

      Range
      55336354..55340765
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039094385.2 → XP_038950313.1  a disintegrin and metallopeptidase domain 26A isoform X1

      UniProtKB/TrEMBL
      A0A8I6A576, Q5U2M5
      Conserved Domains (4) summary
      smart00608
      Location:491 → 626
      ACR; ADAM Cysteine-Rich Domain
      cd04269
      Location:208 → 396
      ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
      pfam00200
      Location:414 → 486
      Disintegrin
      pfam01562
      Location:42 → 160
      Pep_M12B_propep; Reprolysin family propeptide
    Nucleotide Protein Strain
    Heading Accession and Version

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