Mpo myeloperoxidase [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Mpoprovided by RGD
Official Full Name: myeloperoxidaseprovided by RGD
Primary source: RGD:1592081
See related: EnsemblRapid:ENSRNOG00000008310 AllianceGenome:RGD:1592081
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables peroxidase activity. Involved in several processes, including response to food; response to gold nanoparticle; and response to lipopolysaccharide. Located in extracellular space. Used to study acute kidney failure. Biomarker of chronic obstructive pulmonary disease; cystitis; and renovascular hypertension. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease 1; cystic fibrosis; kidney failure (multiple); liver disease (multiple); and lung disease (multiple). Orthologous to human MPO (myeloperoxidase). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Spleen (RPKM 105.3), Thymus (RPKM 100.8) and 4 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q26

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (73092124..73102057)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (72594883..72608862)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (75087892..75098260)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Circ-Plod2 destabilizes Mpo mRNA by binding to IGF2BP2 to promote osteogenic differentiation of bone marrow mesenchymal stem cells.
Title: Circ-Plod2 destabilizes Mpo mRNA by binding to IGF2BP2 to promote osteogenic differentiation of bone marrow mesenchymal stem cells.
Myeloperoxidase instigates proinflammatory responses in a cecal ligation and puncture rat model of sepsis.
Title: Myeloperoxidase instigates proinflammatory responses in a cecal ligation and puncture rat model of sepsis.
These results indicate significant increases of MPO-immunoreactive cells in brain regions affected by neurodegeneration in Parkinson's disease and Alzheimer's Disease.
Title: Myeloperoxidase-immunoreactive cells are significantly increased in brain areas affected by neurodegeneration in Parkinson's and Alzheimer's disease.
Maternal and fetal detrimental changes along with increases in circulating sFlt-1 and VEGF in hypertensive pregnancy may be associated with increases in cardiac and circulating MPO activities, confirming the causative role of inflammatory response in preeclampsia.
Title: Cardiac myeloperoxidase activity is elevated in hypertensive pregnant rats.
Consistent with these in vitro data, in diabetic rat aortas, both MPO expresion and NADPH oxidase activity were increased while the endothelial function was simultaneously impaired. The results suggested that vascular-bound MPO could amplify high glucose-induced vascular injury in diabetes. MPO-NADPH oxidase-HOCl may represent an important pathogenic pathway in diabetic vascular diseases.
Title: Myeloperoxidase amplified high glucose-induced endothelial dysfunction in vasculature: Role of NADPH oxidase and hypochlorous acid.
While myocardial TLR4, MPO and ADMA levels increased in the MIR group, these parameters were found to be decreased significantly in the group treated with apocynin.
Title: Effects of apocynin, an NADPH oxidase inhibitor, on levels of ADMA, MPO, iNOS and TLR4 induced by myocardial ischemia reperfusion.
Upregulation of MPO concomitant with endothelial senescence and dysfunction in hyperlipidemic rats.
Title: Myeloperoxidase-derived hypochlorous acid promotes ox-LDL-induced senescence of endothelial cells through a mechanism involving β-catenin signaling in hyperlipidemia.
the role of leukocyte activation, leukocyte-derived MPO and MPO-generated oxidants on BBB function
Title: Myeloperoxidase-derived oxidants induce blood-brain barrier dysfunction in vitro and in vivo.
MPO has dual functionality under rotenone-exposed conditions, playing a critical regulatory role in modulating pathological and protective events in the brain
Title: Dual functionality of myeloperoxidase in rotenone-exposed brain-resident immune cells.
results demonstrate that, increased expression of MPO in damaged rat and human liver is due to recruited elastase positive neutrophil granulocytes
Title: Myeloperoxidase and elastase are only expressed by neutrophils in normal and in inflamed liver.

Submit: New GeneRIF Correction See all GeneRIFs (20)

General gene information

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Markers

RH144619 (e-PCR)
- UniSTS:233864

D10Chm35 (e-PCR)
- UniSTS:518082

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables heme binding	IEA Inferred from Electronic Annotation more info
enables heparin binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables peroxidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables peroxidase activity	IDA Inferred from Direct Assay more info	PubMed
enables peroxidase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
NOT acts_upstream_of_or_within defense response to Gram-positive bacterium	ISO Inferred from Sequence Orthology more info
involved_in defense response to bacterium	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within defense response to fungus	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within hydrogen peroxide catabolic process	ISO Inferred from Sequence Orthology more info
involved_in hydrogen peroxide catabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within hypochlorous acid biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in low-density lipoprotein particle remodeling	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within removal of superoxide radicals	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within respiratory burst involved in defense response	ISO Inferred from Sequence Orthology more info
involved_in response to food	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to gold nanoparticle	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to lipopolysaccharide	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to mechanical stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to oxidative stress	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within response to yeast	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in azurophil granule	ISO Inferred from Sequence Orthology more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in secretory granule	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: myeloperoxidase

NP_001388741.1

EC 1.11.1.7

XP_006247157.1

EC 1.11.1.7

XP_006247158.1

EC 1.11.1.7

XP_063125167.1

EC 1.11.1.7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001401812.1 → NP_001388741.1 myeloperoxidase precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000010

UniProtKB/TrEMBL

A0A0G2K1A2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086028.1 Reference GRCr8

Range

73092124..73102057

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006247096.5 → XP_006247158.1 myeloperoxidase isoform X1

See identical proteins and their annotated locations for XP_006247158.1

UniProtKB/TrEMBL

A0A0G2K1A2

Related

ENSRNOP00000071759.2, ENSRNOT00000081951.3

Conserved Domains (1) summary

cd09824
Location:289 → 702

myeloperoxidase_like; Myeloperoxidases, eosinophil peroxidases, and lactoperoxidases
XM_006247095.4 → XP_006247157.1 myeloperoxidase isoform X1

See identical proteins and their annotated locations for XP_006247157.1

UniProtKB/TrEMBL

A0A0G2K1A2

Conserved Domains (1) summary

cd09824
Location:289 → 702

myeloperoxidase_like; Myeloperoxidases, eosinophil peroxidases, and lactoperoxidases
XM_063269097.1 → XP_063125167.1 myeloperoxidase isoform X1

UniProtKB/TrEMBL

A0A0G2K1A2

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001107036.1: Suppressed sequence

Description

NM_001107036.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.