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    Nhs NHS actin remodeling regulator [ Rattus norvegicus (Norway rat) ]

    Gene ID: 317494, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Nhsprovided by RGD
    Official Full Name
    NHS actin remodeling regulatorprovided by RGD
    Primary source
    RGD:1561818
    See related
    EnsemblRapid:ENSRNOG00000030759 AllianceGenome:RGD:1561818
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1561818
    Summary
    Predicted to be involved in cell differentiation and lens development in camera-type eye. Predicted to be located in Golgi apparatus; cell junction; and nuclear body. Human ortholog(s) of this gene implicated in Nance-Horan syndrome and cataract 40. Orthologous to human NHS (NHS actin remodeling regulator). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 57.3), Testes (RPKM 12.7) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Nhs in Genome Data Viewer
    Location:
    Xq14
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (36185067..36524711)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (32553300..32892961)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (34312102..34675912)

    Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene similar to ferritin heavy polypeptide-like 17 Neighboring gene heat shock protein family A (Hsp70) member 8, pseudogene 23 Neighboring gene U6 spliceosomal RNA Neighboring gene Scm polycomb group protein like 1 Neighboring gene prohibitin 1 like 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. New mutations in the NHS gene in Nance-Horan Syndrome families from the Netherlands. Florijn RJ, et al. Eur J Hum Genet, 2006 Sep. PMID 16736028
    2. Lens development in a dominant X-linked congenital cataract of the mouse. Grimes PA, et al. Exp Eye Res, 1993 Nov. PMID 8282045
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in lens development in camera-type eye IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within lens development in camera-type eye ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cell junction IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cell junction ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear body IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    actin remodeling regulator NHS
    Names
    Nance-Horan syndrome (congenital cataracts and dental anomalies)
    Nance-Horan syndrome protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001191733.1 → NP_001178662.1  actin remodeling regulator NHS isoform 2

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000021
      UniProtKB/TrEMBL
      F1LU76
      Conserved Domains (1) summary
      pfam15273
      Location:417 → 1037
      NHS; NHS-like

    2. NM_001414726.1 → NP_001401655.1  actin remodeling regulator NHS isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000021
      UniProtKB/TrEMBL
      A0A0G2JXJ0

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086039.1 Reference GRCr8

      Range
      36185067..36524711
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008773173.4 → XP_008771395.1  actin remodeling regulator NHS isoform X2

      Conserved Domains (1) summary
      pfam15273
      Location:263 → 883
      NHS; NHS-like

    2. XM_017602085.3 → XP_017457574.1  actin remodeling regulator NHS isoform X1

      Related
      ENSRNOP00000070291.3, ENSRNOT00000091746.3
    Nucleotide Protein Strain
    Heading Accession and Version

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