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    Kcnj8 potassium inwardly-rectifying channel, subfamily J, member 8 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 25472, updated on 9-Dec-2024

    Summary

    Official Symbol
    Kcnj8provided by RGD
    Official Full Name
    potassium inwardly-rectifying channel, subfamily J, member 8provided by RGD
    Primary source
    RGD:2960
    See related
    EnsemblRapid:ENSRNOG00000013463 AllianceGenome:RGD:2960
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Kir6.1; UKATP1; uKATP-1
    Summary
    Enables ATP binding activity; monoatomic cation transmembrane transporter activity; and sulfonylurea receptor binding activity. Involved in kidney development and potassium ion import across plasma membrane. Located in sarcolemma. Part of inward rectifying potassium channel. Is active in glutamatergic synapse and presynaptic active zone membrane. Used to study hypertension. Biomarker of Parkinsonism and sciatic neuropathy. Orthologous to human KCNJ8 (potassium inwardly rectifying channel subfamily J member 8). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 172.2), Uterus (RPKM 96.9) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Kcnj8 in Genome Data Viewer
    Location:
    4q44
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (177240692..177246548, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (175508908..175515829, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (176783287..176789143, complement)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene glycogen synthase 2 Neighboring gene lactate dehydrogenase B Neighboring gene ATP binding cassette subfamily C member 9 Neighboring gene cytidine monophosphate N-acetylneuraminic acid synthetase

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    General gene information

    Gene Ontology Provided by RGD

    Items 1 - 25 of 59
    Process Evidence Code Pubs
    acts_upstream_of_or_within CAMKK-AMPK signaling cascade  
    acts_upstream_of_or_within NLRP3 inflammasome complex assembly  
    acts_upstream_of_or_within action potential  
    acts_upstream_of_or_within adaptive immune response  
    acts_upstream_of_or_within apoptotic process  
    acts_upstream_of_or_within atrioventricular node cell differentiation  
    acts_upstream_of_or_within blood vessel development  
    acts_upstream_of_or_within calcium ion transmembrane transport  
    acts_upstream_of_or_within cardiac pacemaker cell differentiation  
    acts_upstream_of_or_within cell population proliferation  
    acts_upstream_of_or_within circulatory system development  
    acts_upstream_of_or_within coronary vasculature development  
    acts_upstream_of_or_within defense response to virus  
    acts_upstream_of_or_within determination of adult lifespan  
    acts_upstream_of_or_within establishment of cell polarity  
    acts_upstream_of_or_within fat cell differentiation  
    acts_upstream_of_or_within fatty acid transport  
    acts_upstream_of_or_within fibroblast proliferation  
    acts_upstream_of_or_within gene expression  
    acts_upstream_of_or_within glutamate secretion, neurotransmission  
    acts_upstream_of_or_within heart development  
    acts_upstream_of_or_within heart morphogenesis  
    acts_upstream_of_or_within inflammatory response  
    involved_in inorganic cation transmembrane transport PubMed 
    involved_in kidney development PubMed 
    involved_in membrane repolarization during ventricular cardiac muscle cell action potential  
    acts_upstream_of_or_within microglial cell activation  
    acts_upstream_of_or_within nervous system process  
    acts_upstream_of_or_within neuromuscular process  
    acts_upstream_of_or_within p38MAPK cascade  
    involved_in potassium ion import across plasma membrane  
    involved_in potassium ion import across plasma membrane PubMed 
    involved_in potassium ion import across plasma membrane  
    acts_upstream_of_or_within potassium ion transmembrane transport  
    involved_in potassium ion transport PubMed 
    involved_in potassium ion transport PubMed 
    acts_upstream_of_or_within protein secretion  
    acts_upstream_of_or_within reactive gliosis  
    acts_upstream_of_or_within regulation of blood pressure  
    acts_upstream_of_or_within regulation of cation channel activity  
    acts_upstream_of_or_within regulation of heart rate  
    involved_in regulation of monoatomic ion transmembrane transport  
    involved_in regulation of presynaptic membrane potential  
    acts_upstream_of_or_within response to ATP  
    acts_upstream_of_or_within response to cytokine  
    acts_upstream_of_or_within response to endoplasmic reticulum stress  
    acts_upstream_of_or_within response to exogenous dsRNA  
    acts_upstream_of_or_within response to hypoxia  
    acts_upstream_of_or_within response to insulin  
    acts_upstream_of_or_within response to ischemia  
    acts_upstream_of_or_within response to lipopolysaccharide  
    acts_upstream_of_or_within response to resveratrol  
    acts_upstream_of_or_within response to stress  
    acts_upstream_of_or_within response to xenobiotic stimulus  
    acts_upstream_of_or_within synaptic assembly at neuromuscular junction  
    acts_upstream_of_or_within transmission of nerve impulse  
    acts_upstream_of_or_within vasculature development  
    acts_upstream_of_or_within vasodilation  
    acts_upstream_of_or_within ventricular cardiac muscle tissue development  
    Items 1 - 25 of 59
    Component Evidence Code Pubs
    is_active_in glutamatergic synapse PubMed 
    part_of inward rectifying potassium channel PubMed 
    located_in myofibril  
    is_active_in plasma membrane  
    part_of potassium ion-transporting ATPase complex PubMed 
    is_active_in presynapse  
    is_active_in presynaptic active zone membrane PubMed 
    part_of protein-containing complex  
    located_in sarcolemma PubMed 

    General protein information

    Preferred Names
    ATP-sensitive inward rectifier potassium channel 8
    Names
    Inwardly rectifying potassium channel gene, subfamily J-8 (ATP sensitive)
    inward rectifier K(+) channel Kir6.1
    inwardly rectifier K(+) channel Kir6.1
    potassium channel, inwardly rectifying subfamily J member 8
    potassium voltage-gated channel subfamily J member 8

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_017099.4NP_058795.3  ATP-sensitive inward rectifier potassium channel 8

      See identical proteins and their annotated locations for NP_058795.3

      Status: PROVISIONAL

      Source sequence(s)
      D42145
      UniProtKB/Swiss-Prot
      Q63664, Q9JM49, Q9JM50
      UniProtKB/TrEMBL
      A6IMU7, Q6AYX1
      Related
      ENSRNOP00000018057.3, ENSRNOT00000018057.7
      Conserved Domains (2) summary
      pfam01007
      Location:37184
      IRK; Inward rectifier potassium channel
      pfam17655
      Location:191363
      IRK_C; Inward rectifier potassium channel C-terminal domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      177240692..177246548 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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