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    Tgap1 GTPase activating protein testicular GAP1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 294892, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Tgap1provided by RGD
    Official Full Name
    GTPase activating protein testicular GAP1provided by RGD
    Primary source
    RGD:1359558
    See related
    EnsemblRapid:ENSRNOG00000022511 AllianceGenome:RGD:1359558
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable GTPase activator activity. Predicted to be involved in regulation of Rho protein signal transduction and signal transduction. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward (RPKM 1206.6) See more
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    Genomic context

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    See Tgap1 in Genome Data Viewer
    Location:
    2q23
    Exon count:
    31
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (92270181..92343792)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (90362772..90436415)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (92549413..92625942)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene Spi-C transcription factor, pseudogene 1 Neighboring gene transfer RNA alanine (anticodon AGC) 90 Neighboring gene olfactory receptor family 10 subfamily AG member 62, pseudogene 1 Neighboring gene eukaryotic translation initiation factor 1A, X-linked, pseudogene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. A novel testicular RhoGAP-domain protein induces apoptosis. Modarressi MH, et al. Biol Reprod, 2004 Dec. PMID 15306557, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of Rho protein signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    GTPase activating protein testicular GAP1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001007635.3 → NP_001007636.3  GTPase activating protein testicular GAP1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/TrEMBL
      A6IH33, G3V905, Q5Y9B8
      Conserved Domains (3) summary
      cd04402
      Location:189 → 380
      RhoGAP_ARHGAP20; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP20-like proteins. ArhGAP20, also known as KIAA1391 and RA-RhoGAP, contains a RhoGAP, a RA, and a PH domain, and ANXL repeats. ArhGAP20 is activated by Rap1 and induces ...
      cl02570
      Location:1027 → 1216
      RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...
      cl28922
      Location:25 → 139
      Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      92270181..92343792
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039101957.2 → XP_038957885.1  GTPase activating protein testicular GAP1 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K665, Q5Y9B8
      Related
      ENSRNOP00000073694.1, ENSRNOT00000082912.3
      Conserved Domains (4) summary
      cd04402
      Location:288 → 479
      RhoGAP_ARHGAP20; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP20-like proteins. ArhGAP20, also known as KIAA1391 and RA-RhoGAP, contains a RhoGAP, a RA, and a PH domain, and ANXL repeats. ArhGAP20 is activated by Rap1 and induces ...
      cl02570
      Location:1126 → 1315
      RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...
      cl17171
      Location:14 → 110
      PH-like; Pleckstrin homology-like domain
      cl28922
      Location:124 → 238
      Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold

    2. XM_039101958.2 → XP_038957886.1  GTPase activating protein testicular GAP1 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K665, Q5Y9B8
      Conserved Domains (4) summary
      cd04402
      Location:288 → 479
      RhoGAP_ARHGAP20; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP20-like proteins. ArhGAP20, also known as KIAA1391 and RA-RhoGAP, contains a RhoGAP, a RA, and a PH domain, and ANXL repeats. ArhGAP20 is activated by Rap1 and induces ...
      cl02570
      Location:1126 → 1315
      RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...
      cl17171
      Location:14 → 110
      PH-like; Pleckstrin homology-like domain
      cl28922
      Location:124 → 238
      Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold
    Nucleotide Protein Strain
    Heading Accession and Version

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