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    Il12rb2 interleukin 12 receptor subunit beta 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 171334, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Il12rb2provided by RGD
    Official Full Name
    interleukin 12 receptor subunit beta 2provided by RGD
    Primary source
    RGD:620026
    See related
    EnsemblRapid:ENSRNOG00000007270 AllianceGenome:RGD:620026
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable several functions, including coreceptor activity; cytokine receptor activity; and protein kinase binding activity. Predicted to be involved in interleukin-12-mediated signaling pathway; positive regulation of cell population proliferation; and positive regulation of type II interferon production. Predicted to act upstream of or within peptidyl-tyrosine phosphorylation; response to cytokine; and response to lipopolysaccharide. Predicted to be located in plasma membrane. Predicted to be part of receptor complex. Predicted to be active in external side of plasma membrane. Orthologous to human IL12RB2 (interleukin 12 receptor subunit beta 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Muscle (RPKM 210.6), Brain (RPKM 101.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Il12rb2 in Genome Data Viewer
    Location:
    4q31
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (97756089..97844937, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (96426396..96515251, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (98049195..98141562, complement)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100912188 Neighboring gene growth arrest and DNA-damage-inducible, alpha Neighboring gene uncharacterized LOC120102291 Neighboring gene Serpine1 mRNA binding protein 1 Neighboring gene interleukin 23 receptor Neighboring gene tumor-associated calcium signal transducer 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Role of beta1 and beta2 subunits of the interleukin-12 receptor in determining T helper 1/T helper 2 responses in vivo in the rat. Gillespie KM, et al. Immunology, 2000 Jan. PMID 10651948, Free PMC Article
    2. Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12. Oppmann B, et al. Immunity, 2000 Nov. PMID 11114383
    3. NOD2 is a negative regulator of Toll-like receptor 2-mediated T helper type 1 responses. Watanabe T, et al. Nat Immunol, 2004 Aug. PMID 15220916
    4. A point mutation in the IL-12R beta 2 gene underlies the IL-12 unresponsiveness of Lps-defective C57BL/10ScCr mice. Poltorak A, et al. J Immunol, 2001 Aug 15. PMID 11489994
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables coreceptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables cytokine binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cytokine receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cytokine receptor activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in cytokine-mediated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in interleukin-12-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within peptidyl-tyrosine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cell population proliferation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of type II interferon production ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of T-helper cell differentiation NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within response to cytokine ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within response to lipopolysaccharide ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in external side of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of receptor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    interleukin-12 receptor subunit beta-2
    Names
    interleukin 12 receptor, beta 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001191750.1 → NP_001178679.1  interleukin-12 receptor subunit beta-2 precursor

      See identical proteins and their annotated locations for NP_001178679.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000004
      UniProtKB/TrEMBL
      A6KF50, F1LRH7
      Conserved Domains (2) summary
      cd00063
      Location:240 → 332
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam06328
      Location:28 → 120
      Lep_receptor_Ig; Ig-like C2-type domain

    2. NM_001412558.1 → NP_001399487.1  interleukin-12 receptor subunit beta-2 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000004
      UniProtKB/TrEMBL
      A6KF50, F1LRH7
      Related
      ENSRNOP00000009883.5, ENSRNOT00000009883.8

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      97756089..97844937 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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