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    Fnbp1l formin binding protein 1-like [ Rattus norvegicus (Norway rat) ]

    Gene ID: 310839, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Fnbp1lprovided by RGD
    Official Full Name
    formin binding protein 1-likeprovided by RGD
    Primary source
    RGD:1305386
    See related
    EnsemblRapid:ENSRNOG00000013798 AllianceGenome:RGD:1305386
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Toca-1; RGD1305386
    Summary
    Predicted to enable GTPase binding activity. Predicted to be involved in several processes, including plasma membrane tubulation; positive regulation of filopodium assembly; and vesicle transport along actin filament. Predicted to act upstream of or within cilium assembly. Predicted to be located in cytoplasmic vesicle and cytosol. Orthologous to human FNBP1L (formin binding protein 1 like). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Lung (RPKM 242.8), Kidney (RPKM 240.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Fnbp1l in Genome Data Viewer
    Location:
    2q42
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (213331871..213432821, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (210647241..210748203, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (226691435..226742081, complement)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102555173 Neighboring gene BCAR3 adaptor protein, NSP family member Neighboring gene uncharacterized LOC134485683 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase like 9

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. EFC/F-BAR proteins and the N-WASP-WIP complex induce membrane curvature-dependent actin polymerization. Takano K, et al. EMBO J, 2008 Nov 5. PMID 18923421, Free PMC Article
    2. Toca-1 is suppressed by p53 to limit breast cancer cell invasion and tumor metastasis. Chander H, et al. Breast Cancer Res, 2014 Dec 30. PMID 25547174, Free PMC Article
    3. Regulation of neuronal morphology by Toca-1, an F-BAR/EFC protein that induces plasma membrane invagination. Kakimoto T, et al. J Biol Chem, 2006 Sep 29. PMID 16885158
    4. Cdc42 interaction with N-WASP and Toca-1 regulates membrane tubulation, vesicle formation and vesicle motility: implications for endocytosis. Bu W, et al. PLoS One, 2010 Aug 13. PMID 20730103, Free PMC Article
    5. miR-129-3p controls cilia assembly by regulating CP110 and actin dynamics. Cao J, et al. Nat Cell Biol, 2012 Jun 10. PMID 22684256

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Loss of p53 tumor suppressor function in breast cancers leads to upregulation of Toca-1, and results in enhanced risk of developing metastatic disease.
      Title: Toca-1 is suppressed by p53 to limit breast cancer cell invasion and tumor metastasis.
    2. N-WASP-WIP complex-mediated actin polymerization is activated by phosphatidylserine-containing membranes depending on membrane curvature in the presence of Toca-1 or FBP17 and in the absence of Cdc42 and phosphatidylinositol (4,5)-bisphosphate.
      Title: EFC/F-BAR proteins and the N-WASP-WIP complex induce membrane curvature-dependent actin polymerization.
    3. a vesicle trafficking regulator Toca-1 regulates different aspects of neuronal morphology from N-WASP
      Title: Regulation of neuronal morphology by Toca-1, an F-BAR/EFC protein that induces plasma membrane invagination.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables GTPase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables lipid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in autophagy IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cilium assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in clathrin-dependent endocytosis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in endocytosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in membrane invagination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in nervous system development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in plasma membrane tubulation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of filopodium assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in vesicle budding from membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in vesicle organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in vesicle transport along actin filament ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cell cortex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasmic vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    formin-binding protein 1-like
    Names
    Cdc42 effector
    transducer of Cdc42-dependent actin assembly protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001039609.2 → NP_001034698.1  formin-binding protein 1-like

      See identical proteins and their annotated locations for NP_001034698.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/Swiss-Prot
      Q2HWE9, Q2HWF0
      Related
      ENSRNOP00000090789.1, ENSRNOT00000104633.2
      Conserved Domains (3) summary
      cd07675
      Location:5 → 256
      F-BAR_FNBP1L; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Formin Binding Protein 1-Like
      cd11628
      Location:399 → 479
      HR1_CIP4_FNBP1L; Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of vertebrate Cdc42-Interacting Protein 4 and FormiN Binding Protein 1-Like
      cd12072
      Location:541 → 597
      SH3_FNBP1L; Src Homology 3 domain of Formin Binding Protein 1-Like

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      213331871..213432821 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039102443.2 → XP_038958371.1  formin-binding protein 1-like isoform X4

      UniProtKB/TrEMBL
      A0A8L2QAP0
      Conserved Domains (3) summary
      cd07675
      Location:22 → 269
      F-BAR_FNBP1L; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Formin Binding Protein 1-Like
      cd11628
      Location:412 → 492
      HR1_CIP4_FNBP1L; Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of vertebrate Cdc42-Interacting Protein 4 and FormiN Binding Protein 1-Like
      cd12072
      Location:554 → 610
      SH3_FNBP1L; Src Homology 3 domain of Formin Binding Protein 1-Like

    2. XM_063281952.1 → XP_063138022.1  formin-binding protein 1-like isoform X8

      UniProtKB/Swiss-Prot
      Q2HWE9, Q2HWF0
      UniProtKB/TrEMBL
      A0A8L2QQ20
      Related
      ENSRNOP00000100138.1, ENSRNOT00000136803.1

    3. XM_063281951.1 → XP_063138021.1  formin-binding protein 1-like isoform X7

      UniProtKB/TrEMBL
      A0A8L2QAP0
      Related
      ENSRNOP00000083605.1, ENSRNOT00000116752.2

    4. XM_063281954.1 → XP_063138024.1  formin-binding protein 1-like isoform X10

      UniProtKB/TrEMBL
      A6HVG6, A6HVG7

    5. XM_063281953.1 → XP_063138023.1  formin-binding protein 1-like isoform X9

      UniProtKB/TrEMBL
      A6HVG7

    6. XM_063281946.1 → XP_063138016.1  formin-binding protein 1-like isoform X1

      UniProtKB/TrEMBL
      A0A8L2QAP0

    7. XM_063281950.1 → XP_063138020.1  formin-binding protein 1-like isoform X6

      UniProtKB/TrEMBL
      A0A8L2QAP0

    8. XM_063281949.1 → XP_063138019.1  formin-binding protein 1-like isoform X5

      UniProtKB/TrEMBL
      A0A8L2QAP0

    9. XM_063281948.1 → XP_063138018.1  formin-binding protein 1-like isoform X3

      UniProtKB/TrEMBL
      A0A8L2QAP0
      Related
      ENSRNOP00000019244.7, ENSRNOT00000019244.8

    10. XM_063281947.1 → XP_063138017.1  formin-binding protein 1-like isoform X2

      UniProtKB/Swiss-Prot
      Q2HWE9, Q2HWF0
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q2HWF0.2 GenPept UniProtKB/Swiss-Prot:Q2HWF0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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