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    Clxn calaxin [ Rattus norvegicus (Norway rat) ]

    Gene ID: 301957, updated on 9-Dec-2024

    Summary

    Official Symbol
    Clxnprovided by RGD
    Official Full Name
    calaxinprovided by RGD
    Primary source
    RGD:1594548
    See related
    EnsemblRapid:ENSRNOG00000050091 AllianceGenome:RGD:1594548
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Efcab1
    Summary
    Predicted to enable calcium ion binding activity. Predicted to be involved in regulation of flagellated sperm motility and regulation of signal transduction. Predicted to be located in cilium. Human ortholog(s) of this gene implicated in primary ciliary dyskinesia. Orthologous to human CLXN (calaxin). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Testes (RPKM 32.4), Lung (RPKM 32.1) and 7 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Clxn in Genome Data Viewer
    Location:
    11q23
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (99410925..99500713, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (85977231..85996561, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (90214563..90234319, complement)

    Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102550875 Neighboring gene uncharacterized LOC102550976 Neighboring gene snail family transcriptional repressor 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables calcium ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in regulation of cilium movement ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of flagellated sperm motility ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in cilium ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    calaxin
    Names
    EF hand calcium binding domain 1
    EF-hand calcium-binding domain-containing protein 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106930.1NP_001100400.1  calaxin

      See identical proteins and their annotated locations for NP_001100400.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473999
      UniProtKB/TrEMBL
      A6JSS4, M0RCD9
      Related
      ENSRNOP00000067253.2, ENSRNOT00000071986.3
      Conserved Domains (2) summary
      cd00051
      Location:72131
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam13499
      Location:106175
      EF-hand_7; EF-hand domain pair

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086029.1 Reference GRCr8

      Range
      99410925..99500713 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039088258.2XP_038944186.1  calaxin isoform X1

      Conserved Domains (1) summary
      pfam13499
      Location:72141
      EF-hand_7; EF-hand domain pair
    2. XM_063270453.1XP_063126523.1  calaxin isoform X2

    RNA

    1. XR_010055948.1 RNA Sequence

    2. XR_005491018.2 RNA Sequence

    3. XR_010055947.1 RNA Sequence