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    Trpv6 transient receptor potential cation channel, subfamily V, member 6 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 114246, updated on 4-Jan-2025

    Summary

    Official Symbol
    Trpv6provided by RGD
    Official Full Name
    transient receptor potential cation channel, subfamily V, member 6provided by RGD
    Primary source
    RGD:69335
    See related
    EnsemblRapid:ENSRNOG00000014714 AllianceGenome:RGD:69335
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    CaT1; Ecac2; Otrpc3
    Summary
    Enables calcium channel activity and identical protein binding activity. Involved in calcium ion import across plasma membrane and protein homotetramerization. Predicted to be located in apical plasma membrane. Predicted to be part of calcium channel complex. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in hyperparathyroidism. Orthologous to human TRPV6 (transient receptor potential cation channel subfamily V member 6). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Biased expression in Thymus (RPKM 105.9), Uterus (RPKM 48.0) and 4 other tissues See more
    Orthologs
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    Genomic context

    See Trpv6 in Genome Data Viewer
    Location:
    4q23
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (71474006..71489667, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (70507347..70523013, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (70918631..70934291, complement)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene U6 spliceosomal RNA Neighboring gene Eph receptor B6 Neighboring gene transient receptor potential cation channel, subfamily V, member 5 Neighboring gene LLLL and CFNLAS motif containing 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables calcium channel activity  
    enables calcium channel activity PubMed 
    enables calcium channel activity  
    enables calcium channel activity  
    enables calcium-activated cation channel activity PubMed 
    enables calmodulin binding  
    enables calmodulin binding  
    enables calmodulin binding  
    enables identical protein binding  
    enables identical protein binding PubMed 
    enables identical protein binding  
    enables metal ion binding  
    Process Evidence Code Pubs
    involved_in calcium ion homeostasis  
    acts_upstream_of_or_within calcium ion homeostasis  
    involved_in calcium ion homeostasis  
    involved_in calcium ion homeostasis  
    involved_in calcium ion import PubMed 
    involved_in calcium ion import across plasma membrane  
    involved_in calcium ion import across plasma membrane  
    involved_in calcium ion import across plasma membrane PubMed 
    involved_in calcium ion import across plasma membrane  
    involved_in calcium ion import across plasma membrane  
    involved_in calcium ion transmembrane transport PubMed 
    involved_in calcium ion transmembrane transport  
    acts_upstream_of_or_within calcium ion transport  
    involved_in calcium ion transport  
    involved_in parathyroid hormone secretion  
    acts_upstream_of_or_within parathyroid hormone secretion  
    involved_in protein homotetramerization PubMed 
    involved_in response to calcium ion  
    involved_in response to calcium ion  
    involved_in response to calcium ion  
    Component Evidence Code Pubs
    located_in apical plasma membrane PubMed 
    part_of calcium channel complex  
    part_of calcium channel complex  
    is_active_in plasma membrane  
    located_in plasma membrane  
    located_in plasma membrane  
    located_in plasma membrane  

    General protein information

    Preferred Names
    transient receptor potential cation channel subfamily V member 6
    Names
    calcium transport protein 1
    epithelial apical membrane calcium transporter/channel CaT1
    epithelial calcium channel 2
    osmosensitive transient receptor potential channel 3
    transient receptor potential cation channel, subfamily 5, member 6

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053686.2NP_446138.2  transient receptor potential cation channel subfamily V member 6

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000004
      UniProtKB/TrEMBL
      A6IF47, B6ZDS2
      Related
      ENSRNOP00000020616.3, ENSRNOT00000020616.5
      Conserved Domains (2) summary
      sd00045
      Location:116147
      ANK; ANK repeat [structural motif]
      cd22192
      Location:29636
      TRPV5-6; Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      71474006..71489667 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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