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    Srgap3 SLIT-ROBO Rho GTPase activating protein 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 500287, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Srgap3provided by RGD
    Official Full Name
    SLIT-ROBO Rho GTPase activating protein 3provided by RGD
    Primary source
    RGD:1563152
    See related
    EnsemblRapid:ENSRNOG00000006509 AllianceGenome:RGD:1563152
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1563152
    Summary
    Predicted to be involved in negative regulation of cell migration and regulation of postsynapse assembly. Predicted to be active in cytoplasm; glutamatergic synapse; and postsynapse. Orthologous to human SRGAP3 (SLIT-ROBO Rho GTPase activating protein 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 76.1), Adrenal (RPKM 36.0) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Srgap3 in Genome Data Viewer
    Location:
    4q42
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (147391082..147626407, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (145839369..146070556, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (144638782..144869961, complement)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene oxytocin receptor Neighboring gene RAD18 E3 ubiquitin protein ligase Neighboring gene uncharacterized LOC102548080 Neighboring gene small nucleolar RNA U3 Neighboring gene uncharacterized LOC102548337 Neighboring gene uncharacterized LOC134486622

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The mental retardation-associated protein srGAP3 regulates survival, proliferation, and differentiation of rat embryonic neural stem/progenitor cells. Lu H, et al. Stem Cells Dev, 2013 Jun 1. PMID 23311320
    2. Regulated shuttling of Slit-Robo-GTPase activating proteins between nucleus and cytoplasm during brain development. Yao Q, et al. Cell Mol Neurobiol, 2008 Feb. PMID 17710530
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. results provide strong evidence that srGAP3 is involved in the regulation of biological behavior and the morphological features in neural stem cells/neural progenitor cells in vitro
      Title: The mental retardation-associated protein srGAP3 regulates survival, proliferation, and differentiation of rat embryonic neural stem/progenitor cells.
    2. results suggest that srGAPs are not only involved in the regulation of the Slit-Robo signal transduction, but also in neuronal development and that the translocation of srGAPs is important for their functions
      Title: Regulated shuttling of Slit-Robo-GTPase activating proteins between nucleus and cytoplasm during brain development.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of postsynapse assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in postsynapse ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    SLIT-ROBO Rho GTPase-activating protein 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001191975.1 → NP_001178904.1  SLIT-ROBO Rho GTPase-activating protein 3

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000004
      UniProtKB/TrEMBL
      A0A8I6GHT9, F1M5M9
      Related
      ENSRNOP00000009066.5, ENSRNOT00000009066.8
      Conserved Domains (3) summary
      cd07684
      Location:26 → 278
      F-BAR_srGAP3; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Slit-Robo GTPase Activating Protein 3
      cd11955
      Location:748 → 800
      SH3_srGAP1-3; Src homology 3 domain of Slit-Robo GTPase Activating Proteins 1, 2, and 3
      cd04383
      Location:502 → 689
      RhoGAP_srGAP; RhoGAP_srGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in srGAPs. srGAPs are components of the intracellular part of Slit-Robo signalling pathway that is important for axon guidance and cell migration. srGAPs ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      147391082..147626407 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006237048.5 → XP_006237110.1  SLIT-ROBO Rho GTPase-activating protein 3 isoform X2

      UniProtKB/TrEMBL
      A0A8I6GF18, A0A8I6GHT9
      Related
      ENSRNOP00000086528.1, ENSRNOT00000108871.2
      Conserved Domains (3) summary
      cd07684
      Location:26 → 278
      F-BAR_srGAP3; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Slit-Robo GTPase Activating Protein 3
      cd11955
      Location:724 → 776
      SH3_srGAP1-3; Src homology 3 domain of Slit-Robo GTPase Activating Proteins 1, 2, and 3
      cd04383
      Location:481 → 665
      RhoGAP_srGAP; RhoGAP_srGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in srGAPs. srGAPs are components of the intracellular part of Slit-Robo signalling pathway that is important for axon guidance and cell migration. srGAPs ...

    2. XM_039108203.2 → XP_038964131.1  SLIT-ROBO Rho GTPase-activating protein 3 isoform X3

      UniProtKB/TrEMBL
      A6IBN6
      Conserved Domains (3) summary
      cd07684
      Location:26 → 278
      F-BAR_srGAP3; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Slit-Robo GTPase Activating Protein 3
      cd11955
      Location:753 → 805
      SH3_srGAP1-3; Src homology 3 domain of Slit-Robo GTPase Activating Proteins 1, 2, and 3
      cd04383
      Location:510 → 694
      RhoGAP_srGAP; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in srGAPs. srGAPs are components of the intracellular part of Slit-Robo signalling pathway that is important for axon guidance and cell migration. srGAPs contain an ...

    3. XM_039108202.2 → XP_038964130.1  SLIT-ROBO Rho GTPase-activating protein 3 isoform X1

      UniProtKB/TrEMBL
      A0A8I6GHT9
      Related
      ENSRNOP00000089134.2, ENSRNOT00000117854.2
      Conserved Domains (3) summary
      cd07684
      Location:26 → 278
      F-BAR_srGAP3; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Slit-Robo GTPase Activating Protein 3
      cd11955
      Location:753 → 805
      SH3_srGAP1-3; Src homology 3 domain of Slit-Robo GTPase Activating Proteins 1, 2, and 3
      cd04383
      Location:510 → 694
      RhoGAP_srGAP; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in srGAPs. srGAPs are components of the intracellular part of Slit-Robo signalling pathway that is important for axon guidance and cell migration. srGAPs contain an ...
    Nucleotide Protein Strain
    Heading Accession and Version

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