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    Rfx6 regulatory factor X, 6 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 294395, updated on 9-Dec-2024

    Summary

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    Symbol
    Rfx6provided by RGD
    Full Name
    regulatory factor X, 6provided by RGD
    Primary source
    RGD:1307491
    See related
    EnsemblRapid:ENSRNOG00000027949 AllianceGenome:RGD:1307491
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Rfxdc1
    Summary
    Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in several processes, including enteroendocrine cell differentiation; positive regulation of insulin secretion involved in cellular response to glucose stimulus; and positive regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Orthologous to human RFX6 (regulatory factor X6). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 12.0), Liver (RPKM 8.1) and 2 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Rfx6 in Genome Data Viewer
    Location:
    20q11
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (31562490..31615967)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (31019784..31073266)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (32709282..32764040)

    Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene glyceraldehyde-3-phosphate dehydrogenase-like Neighboring gene G protein-coupled receptor, class C, group 6, member A Neighboring gene eukaryotic translation elongation factor 1 beta 2, pseudogene 2 Neighboring gene ribosome biogenesis protein NSA2 homolog Neighboring gene uncharacterized LOC102555143 Neighboring gene basic transcription factor 3, pseudogene 9

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. RFX6 regulates insulin secretion by modulating Ca2+ homeostasis in human β cells. Chandra V, et al. Cell Rep, 2014 Dec 24. PMID 25497100
    2. Rfx6 directs islet formation and insulin production in mice and humans. Smith SB, et al. Nature, 2010 Feb 11. PMID 20148032, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transcription cis-regulatory region binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in endocrine pancreas development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in glucose homeostasis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in pancreatic A cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in pancreatic D cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in pancreatic epsilon cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of insulin secretion involved in cellular response to glucose stimulus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of insulin secretion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in type B pancreatic cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    DNA-binding protein RFX6
    Names
    DNA-binding protein RFX6-like
    regulatory factor X domain containing 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001414918.1 → NP_001401847.1  DNA-binding protein RFX6

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000020
      UniProtKB/TrEMBL
      A0A8I6AS29, A6K474, F1LTN7
      Related
      ENSRNOP00000095759.1, ENSRNOT00000102360.2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086038.1 Reference GRCr8

      Range
      31562490..31615967
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063279068.1 → XP_063135138.1  DNA-binding protein RFX6 isoform X1

      UniProtKB/TrEMBL
      A6K474, F1LTN7

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001106388.1: Suppressed sequence

      Description
      NM_001106388.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version

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