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    Proca1 protein interacting with cyclin A1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 497959, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Proca1provided by RGD
    Official Full Name
    protein interacting with cyclin A1provided by RGD
    Primary source
    RGD:1561727
    See related
    EnsemblRapid:ENSRNOG00000023381 AllianceGenome:RGD:1561727
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable cyclin binding activity. Predicted to be involved in mitochondrial electron transport, cytochrome c to oxygen and mitochondrial protein catabolic process. Predicted to be located in mitochondrion. Orthologous to human PROCA1 (protein interacting with cyclin A1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Testes (RPKM 228.3), Adrenal (RPKM 26.0) and 7 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Proca1 in Genome Data Viewer
    Location:
    10q25
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (63588061..63601011)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (63090018..63102941)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (65454451..65469491)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA, C/D box 42B Neighboring gene ribosomal protein L23A Neighboring gene RAB34, member RAS oncogene family Neighboring gene SPT6 homolog, histone chaperone and transcription elongation factor Neighboring gene stromal cell derived factor 2 Neighboring gene bridge-like lipid transfer protein family member 2 Neighboring gene uncharacterized LOC120095269 Neighboring gene U6 spliceosomal RNA

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Identification of interaction partners and substrates of the cyclin A1-CDK2 complex. Diederichs S, et al. J Biol Chem, 2004 Aug 6. PMID 15159402
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Clone Names

    • MGC116192

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables cyclin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phospholipase A2 activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in arachidonate secretion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitochondrial electron transport, cytochrome c to oxygen ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in mitochondrial protein catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in mitochondrion organization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in phospholipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    protein PROCA1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001025758.1 → NP_001020929.1  protein PROCA1

      See identical proteins and their annotated locations for NP_001020929.1

      Status: PROVISIONAL

      Source sequence(s)
      BC098036
      UniProtKB/Swiss-Prot
      Q4V7B4
      UniProtKB/TrEMBL
      A0A8I6AIT3
      Related
      ENSRNOP00000031483.4, ENSRNOT00000037048.6
      Conserved Domains (1) summary
      cd04705
      Location:30 → 125
      PLA2_group_III_like; PLA2_group_III_like: A sub-family of Phospholipase A2, similar to human group III PLA2. PLA2 is a super-family of secretory and cytosolic enzymes; the latter are either Ca dependent or Ca independent. Enzymatically active PLA2 cleaves the sn-2 position ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      63588061..63601011
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039086607.2 → XP_038942535.1  protein PROCA1 isoform X1

      UniProtKB/TrEMBL
      A0A8I6AIT3
      Related
      ENSRNOP00000093454.2, ENSRNOT00000095582.2
      Conserved Domains (1) summary
      cd04705
      Location:5 → 98
      PLA2_group_III_like; A sub-family of Phospholipase A2, similar to human group III PLA2. PLA2 is a super-family of secretory and cytosolic enzymes; the latter are either Ca dependent or Ca independent. Enzymatically active PLA2 cleaves the sn-2 position of the glycerol ...

    2. XM_039086609.2 → XP_038942537.1  protein PROCA1 isoform X2

      UniProtKB/TrEMBL
      A0A8I6AIT3
      Related
      ENSRNOP00000104168.1, ENSRNOT00000166228.1
      Conserved Domains (1) summary
      cd04705
      Location:1 → 77
      PLA2_group_III_like; A sub-family of Phospholipase A2, similar to human group III PLA2. PLA2 is a super-family of secretory and cytosolic enzymes; the latter are either Ca dependent or Ca independent. Enzymatically active PLA2 cleaves the sn-2 position of the glycerol ...

    3. XM_039086608.2 → XP_038942536.1  protein PROCA1 isoform X2

      UniProtKB/TrEMBL
      A0A8I6AIT3
      Conserved Domains (1) summary
      cd04705
      Location:1 → 77
      PLA2_group_III_like; A sub-family of Phospholipase A2, similar to human group III PLA2. PLA2 is a super-family of secretory and cytosolic enzymes; the latter are either Ca dependent or Ca independent. Enzymatically active PLA2 cleaves the sn-2 position of the glycerol ...

    4. XM_039086610.2 → XP_038942538.1  protein PROCA1 isoform X2

      UniProtKB/TrEMBL
      A0A8I6AIT3
      Conserved Domains (1) summary
      cd04705
      Location:1 → 77
      PLA2_group_III_like; A sub-family of Phospholipase A2, similar to human group III PLA2. PLA2 is a super-family of secretory and cytosolic enzymes; the latter are either Ca dependent or Ca independent. Enzymatically active PLA2 cleaves the sn-2 position of the glycerol ...

    5. XM_039086612.2 → XP_038942540.1  protein PROCA1 isoform X2

      UniProtKB/TrEMBL
      A0A8I6AIT3
      Conserved Domains (1) summary
      cd04705
      Location:1 → 77
      PLA2_group_III_like; A sub-family of Phospholipase A2, similar to human group III PLA2. PLA2 is a super-family of secretory and cytosolic enzymes; the latter are either Ca dependent or Ca independent. Enzymatically active PLA2 cleaves the sn-2 position of the glycerol ...

    6. XM_063269637.1 → XP_063125707.1  protein PROCA1 isoform X3

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q4V7B4.1 GenPept UniProtKB/Swiss-Prot:Q4V7B4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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