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    Cwf19l1 CWF19 like cell cycle control factor 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 365465, updated on 4-Jan-2025

    Summary

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    Official Symbol
    Cwf19l1provided by RGD
    Official Full Name
    CWF19 like cell cycle control factor 1provided by RGD
    Primary source
    RGD:1304716
    See related
    EnsemblRapid:ENSRNOG00000012763 AllianceGenome:RGD:1304716
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable RNA lariat debranching enzyme activator activity. Predicted to be involved in mRNA splicing, via spliceosome. Predicted to be part of post-mRNA release spliceosomal complex. Human ortholog(s) of this gene implicated in autosomal recessive spinocerebellar ataxia 17. Orthologous to human CWF19L1 (CWF19 like cell cycle control factor 1). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Biased expression in Thymus (RPKM 145.0), Spleen (RPKM 122.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Cwf19l1 in Genome Data Viewer
    Location:
    1q54
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (252946934..252970194, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (242997720..243020989, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (263887014..263910251, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene ER lipid raft associated 1 Neighboring gene component of inhibitor of nuclear factor kappa B kinase complex Neighboring gene uncharacterized LOC134484059 Neighboring gene small nucleolar RNA, H/ACA box 12 Neighboring gene biogenesis of lysosomal organelles complex-1, subunit 2 Neighboring gene polycystin 2 like 1, transient receptor potential cation channel Neighboring gene RNA, U6 small nuclear 630

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables RNA lariat debranching enzyme activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of post-mRNA release spliceosomal complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    CWF19-like protein 1
    Names
    CWF19-like 1, cell cycle control

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108928.1 → NP_001102398.1  CWF19-like protein 1

      See identical proteins and their annotated locations for NP_001102398.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473986
      UniProtKB/TrEMBL
      A6JHE9, D3Z863
      Related
      ENSRNOP00000017202.4, ENSRNOT00000017202.7
      Conserved Domains (3) summary
      cd07380
      Location:9 → 229
      MPP_CWF19_N; Schizosaccharomyces pombe CWF19 and related proteins, N-terminal metallophosphatase domain
      pfam04676
      Location:442 → 534
      CwfJ_C_2; Protein similar to CwfJ C-terminus 2
      cl00228
      Location:327 → 422
      HIT_like; HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      252946934..252970194 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017589505.3 → XP_017444994.1  CWF19-like protein 1 isoform X1

      Conserved Domains (3) summary
      cd07380
      Location:9 → 91
      MPP_CWF19_N; Schizosaccharomyces pombe CWF19 and related proteins, N-terminal metallophosphatase domain
      pfam04676
      Location:304 → 396
      CwfJ_C_2; Protein similar to CwfJ C-terminus 2
      cl00228
      Location:189 → 284
      HIT_like; HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis ...

    2. XM_017589506.3 → XP_017444995.1  CWF19-like protein 1 isoform X1

      Conserved Domains (3) summary
      cd07380
      Location:9 → 91
      MPP_CWF19_N; Schizosaccharomyces pombe CWF19 and related proteins, N-terminal metallophosphatase domain
      pfam04676
      Location:304 → 396
      CwfJ_C_2; Protein similar to CwfJ C-terminus 2
      cl00228
      Location:189 → 284
      HIT_like; HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis ...

    RNA

    1. XR_005489775.2 RNA Sequence

    2. XR_005489773.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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