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    Trim69 tripartite motif-containing 69 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 311373, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Trim69provided by RGD
    Official Full Name
    tripartite motif-containing 69provided by RGD
    Primary source
    RGD:1305074
    See related
    EnsemblRapid:ENSRNOG00000017157 AllianceGenome:RGD:1305074
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Rnf36
    Summary
    Predicted to enable identical protein binding activity and ubiquitin protein ligase activity. Predicted to be involved in innate immune response and protein localization to centrosome. Predicted to be located in nuclear speck. Predicted to be active in centrosome and cytoplasm. Orthologous to human TRIM69 (tripartite motif containing 69). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Testes (RPKM 67.8), Spleen (RPKM 16.0) and 7 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Trim69 in Genome Data Viewer
    Location:
    3q35
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (129565060..129585629)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (109111468..109135255)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (114103011..114123293)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene PAT1 homolog 2 Neighboring gene beta-2 microglobulin Neighboring gene telomere repeat binding bouquet formation protein 2 Neighboring gene uncharacterized LOC134486430 Neighboring gene sorbitol dehydrogenase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Characterisation of human RING finger protein TRIM69, a novel testis E3 ubiquitin ligase and its subcellular localisation. Han Y, et al. Biochem Biophys Res Commun, 2012 Dec 7. PMID 23131556
    2. Maturation of human dendritic cells is accompanied by functional remodelling of the ubiquitin-proteasome system. Ebstein F, et al. Int J Biochem Cell Biol, 2009 May. PMID 19028597
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC108781

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin protein ligase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin-protein transferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin-protein transferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in innate immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein localization to centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear speck ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    E3 ubiquitin-protein ligase TRIM69
    Names
    RING-type E3 ubiquitin transferase TRIM69
    ring finger protein 36
    tripartite motif-containing protein 69
    NP_001013178.1
    XP_006234918.2
    XP_038960903.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001013160.1 → NP_001013178.1  E3 ubiquitin-protein ligase TRIM69

      See identical proteins and their annotated locations for NP_001013178.1

      Status: PROVISIONAL

      Source sequence(s)
      BC091171
      UniProtKB/Swiss-Prot
      Q5BK82
      UniProtKB/TrEMBL
      A6HPR7
      Related
      ENSRNOP00000111864.1, ENSRNOT00000135410.1
      Conserved Domains (2) summary
      pfam15227
      Location:41 → 81
      zf-C3HC4_4; zinc finger of C3HC4-type, RING
      cl02614
      Location:311 → 496
      SPRY; SPRY domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      129565060..129585629
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039104975.2 → XP_038960903.1  E3 ubiquitin-protein ligase TRIM69 isoform X2

      Conserved Domains (4) summary
      TIGR00599
      Location:92 → 184
      rad18; DNA repair protein rad18
      cd00162
      Location:119 → 159
      RING_Ubox; RING-HC finger (C3HC4-type) [structural motif]
      cl00034
      Location:193 → 219
      Bbox_SF; B-box-type zinc finger superfamily
      cl17238
      Location:116 → 160
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

    2. XM_006234856.5 → XP_006234918.2  E3 ubiquitin-protein ligase TRIM69 isoform X1

      Related
      ENSRNOP00000023209.5, ENSRNOT00000023209.8
      Conserved Domains (2) summary
      pfam15227
      Location:119 → 159
      zf-C3HC4_4; zinc finger of C3HC4-type, RING
      cl02614
      Location:389 → 574
      SPRY; SPRY domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5BK82.1 GenPept UniProtKB/Swiss-Prot:Q5BK82

    Gene LinkOut

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