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    Tanc1 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 311055, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Tanc1provided by RGD
    Official Full Name
    tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1provided by RGD
    Primary source
    RGD:1302949
    See related
    EnsemblRapid:ENSRNOG00000025394 AllianceGenome:RGD:1302949
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Tanc
    Summary
    Involved in regulation of postsynapse organization. Is active in glutamatergic synapse and postsynaptic density, intracellular component. Orthologous to human TANC1 (tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 110.7), Lung (RPKM 56.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Tanc1 in Genome Data Viewer
    Location:
    3q21
    Exon count:
    29
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (64508037..64741826)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (44099387..44335478)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (45683773..45917687)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene death associated protein-like 1 Neighboring gene U6 spliceosomal RNA Neighboring gene uncharacterized LOC134486097 Neighboring gene uncharacterized LOC108350580 Neighboring gene WD repeat, sterile alpha motif and U-box domain containing 1 Neighboring gene bromodomain adjacent to zinc finger domain, 2B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Drosophila and mammalian models uncover a role for the myoblast fusion gene TANC1 in rhabdomyosarcoma. Avirneni-Vadlamudi U, et al. J Clin Invest, 2012 Jan. PMID 22182840, Free PMC Article
    2. Regulation of dendritic spines, spatial memory, and embryonic development by the TANC family of PSD-95-interacting proteins. Han S, et al. J Neurosci, 2010 Nov 10. PMID 21068316, Free PMC Article
    3. MINK is a Rap2 effector for phosphorylation of the postsynaptic scaffold protein TANC1. Nonaka H, et al. Biochem Biophys Res Commun, 2008 Dec 12. PMID 18930710
    4. Seizures are regulated by ubiquitin-specific peptidase 9 X-linked (USP9X), a de-ubiquitinase. Paemka L, et al. PLoS Genet, 2015 Mar. PMID 25763846, Free PMC Article
    5. A novel scaffold protein, TANC, possibly a rat homolog of Drosophila rolling pebbles (rols), forms a multiprotein complex with various postsynaptic density proteins. Suzuki T, et al. Eur J Neurosci, 2005 Jan. PMID 15673434

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. TANC protein may work as a postsynaptic scaffold component by forming a multiprotein complex with various postsynaptic density proteins.
      Title: A novel scaffold protein, TANC, possibly a rat homolog of Drosophila rolling pebbles (rols), forms a multiprotein complex with various postsynaptic density proteins.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA1728

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in dendritic spine maintenance IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within dendritic spine maintenance ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in myoblast fusion IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within myoblast fusion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of postsynapse organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of postsynapse organization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of postsynapse organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in visual learning IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within visual learning ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in axon terminus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in axon terminus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in dendrite IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in dendrite ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in glutamatergic synapse IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in glutamatergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in neuronal cell body IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in postsynaptic density, intracellular component IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in postsynaptic density, intracellular component IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    protein TANC1
    Names
    TPR domain, ankyrin-repeat and coiled-coil domain-containing protein 1
    TPR domain, ankyrin-repeat and coiled-coil-containing

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001002854.2 → NP_001002854.2  protein TANC1 isoform a

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/Swiss-Prot
      Q6F6B3

    2. NM_001431669.1 → NP_001418598.1  protein TANC1 isoform b

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003

    3. NM_001431670.1 → NP_001418599.1  protein TANC1 isoform b

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      64508037..64741826
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063283615.1 → XP_063139685.1  protein TANC1 isoform X1

      UniProtKB/Swiss-Prot
      Q6F6B3
      UniProtKB/TrEMBL
      A6JF67, G3V917

    2. XM_006234204.4 → XP_006234266.1  protein TANC1 isoform X1

      See identical proteins and their annotated locations for XP_006234266.1

      UniProtKB/Swiss-Prot
      Q6F6B3
      UniProtKB/TrEMBL
      A6JF67, G3V917
      Related
      ENSRNOP00000033136.6, ENSRNOT00000038983.7
      Conserved Domains (5) summary
      PHA03095
      Location:903 → 1215
      PHA03095; ankyrin-like protein; Provisional
      COG0457
      Location:1282 → 1413
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      sd00006
      Location:1289 → 1314
      TPR; TPR repeat [structural motif]
      sd00045
      Location:1142 → 1172
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:1113 → 1205
      Ank_2; Ankyrin repeats (3 copies)

    3. XM_017591681.3 → XP_017447170.1  protein TANC1 isoform X2

      Related
      ENSRNOP00000088260.1, ENSRNOT00000115662.2

    4. XM_039104830.2 → XP_038960758.1  protein TANC1 isoform X1

      UniProtKB/Swiss-Prot
      Q6F6B3
      UniProtKB/TrEMBL
      A6JF67, G3V917
      Conserved Domains (5) summary
      PHA03095
      Location:903 → 1215
      PHA03095; ankyrin-like protein; Provisional
      COG0457
      Location:1282 → 1413
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      sd00006
      Location:1289 → 1314
      TPR; TPR repeat [structural motif]
      sd00045
      Location:1142 → 1172
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:1113 → 1205
      Ank_2; Ankyrin repeats (3 copies)

    5. XM_063283616.1 → XP_063139686.1  protein TANC1 isoform X2

      UniProtKB/Swiss-Prot
      Q6F6B3
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6F6B3.1 GenPept UniProtKB/Swiss-Prot:Q6F6B3

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