Kcnk13 potassium two pore domain channel subfamily K member 13 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Kcnk13provided by RGD
Official Full Name: potassium two pore domain channel subfamily K member 13provided by RGD
Primary source: RGD:68941
See related: EnsemblRapid:ENSRNOG00000047363 AllianceGenome:RGD:68941
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: prdx1; THIK-1
Summary: Predicted to enable outward rectifier potassium channel activity and potassium ion leak channel activity. Predicted to be involved in potassium ion transmembrane transport. Predicted to be located in membrane. Predicted to be part of monoatomic ion channel complex. Predicted to be active in plasma membrane. Orthologous to human KCNK13 (potassium two pore domain channel subfamily K member 13). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Spleen (RPKM 27.2), Brain (RPKM 11.4) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 6q32

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	6	NC_086024.1 (124970363..125074919)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	6	NC_051341.1 (119240825..119345292)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	6	NC_005105.4 (123971030..124077249)

Chromosome 6 - NC_086024.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

KCNK13 potassium channels in the ventral tegmental area of rats are important for excitation of ventral tegmental area neurons by ethanol.
Title: KCNK13 potassium channels in the ventral tegmental area of rats are important for excitation of ventral tegmental area neurons by ethanol.
Inhibiting THIK-1 function depolarizes microglia. Block of THIK-1 function also inhibits release of the pro-inflammatory cytokine interleukin-1beta from activated microglia, consistent with K(+) loss being needed for inflammasome assembly.
Title: Microglial Ramification, Surveillance, and Interleukin-1β Release Are Regulated by the Two-Pore Domain K(+) Channel THIK-1.
DRG neurons of all sizes express THIK1. Cutaneous inflammation downregulates THIK1 expression in only small DRG neurons.
Title: Cutaneous inflammation regulates THIK1 expression in small C-like nociceptor dorsal root ganglion neurons.
THIK-1 and THIK-2 are abundantly expressed in the proximal and distal nephron of the mammalian kidney.
Title: Cellular localization of THIK-1 (K(2P)13.1) and THIK-2 (K(2P)12.1) K channels in the mammalian kidney.

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISS Inferred from Sequence or Structural Similarity more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables outward rectifier potassium channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables potassium channel activity	IDA Inferred from Direct Assay more info	PubMed
enables potassium channel activity	IEA Inferred from Electronic Annotation more info
enables potassium channel activity	ISO Inferred from Sequence Orthology more info
enables potassium ion leak channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein heterodimerization activity	IEA Inferred from Electronic Annotation more info
enables protein heterodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein heterodimerization activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in potassium ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in potassium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in regulation of NLRP3 inflammasome complex assembly	IEA Inferred from Electronic Annotation more info
involved_in regulation of NLRP3 inflammasome complex assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of excitatory synapse pruning	IEA Inferred from Electronic Annotation more info
involved_in regulation of excitatory synapse pruning	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of resting membrane potential	IEA Inferred from Electronic Annotation more info
involved_in regulation of resting membrane potential	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
part_of monoatomic ion channel complex	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: potassium channel subfamily K member 13

Names: potassium channel, subfamily K, member 13; potassium channel, two pore domain subfamily K, member 13; tandem pore domain halothane-inhibited potassium channel 1; tandem pore domain potassium channel THIK-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_022293.3 → NP_071629.2 potassium channel subfamily K member 13

Status: VALIDATED

Source sequence(s)

JAXUCZ010000006

UniProtKB/Swiss-Prot

Q9ERS0

UniProtKB/TrEMBL

A6JEG6, M0RCJ1

Related

ENSRNOP00000067310.1, ENSRNOT00000075794.4

Conserved Domains (1) summary

pfam07885
Location:88 → 150

Ion_trans_2; Ion channel

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086024.1 Reference GRCr8

Range

124970363..125074919

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006240447.5 → XP_006240509.1 potassium channel subfamily K member 13 isoform X1

Conserved Domains (1) summary

pfam07885
Location:88 → 150

Ion_trans_2; Ion channel
XM_063262443.1 → XP_063118513.1 potassium channel subfamily K member 13 isoform X2
XM_039112874.2 → XP_038968802.1 potassium channel subfamily K member 13 isoform X2

Conserved Domains (1) summary

pfam07885
Location:89 → 171

Ion_trans_2; Ion channel