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    Prkar2b protein kinase cAMP-dependent type II regulatory subunit beta [ Rattus norvegicus (Norway rat) ]

    Gene ID: 24679, updated on 9-Dec-2024

    Summary

    Official Symbol
    Prkar2bprovided by RGD
    Official Full Name
    protein kinase cAMP-dependent type II regulatory subunit betaprovided by RGD
    Primary source
    RGD:3394
    See related
    EnsemblRapid:ENSRNOG00000009079 AllianceGenome:RGD:3394
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RATDNA
    Summary
    Enables cAMP binding activity; cAMP-dependent protein kinase regulator activity; and protein domain specific binding activity. Involved in regulation of protein kinase activity and response to antipsychotic drug. Located in dendrite; neuronal cell body; and perinuclear region of cytoplasm. Part of cAMP-dependent protein kinase complex. Orthologous to human PRKAR2B (protein kinase cAMP-dependent type II regulatory subunit beta). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 683.9), Adrenal (RPKM 590.0) and 7 other tissues See more
    Orthologs
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    Genomic context

    See Prkar2b in Genome Data Viewer
    Location:
    6q16
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (54291143..54381639, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (48563659..48653933, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (51265509..51356383, complement)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene component of oligomeric golgi complex 5 Neighboring gene G protein-coupled receptor 22 Neighboring gene large ribosomal subunit protein eL20-like Neighboring gene HMG-box transcription factor 1 Neighboring gene U1 spliceosomal RNA Neighboring gene uncharacterized LOC134479360 Neighboring gene phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Clone Names

    • MGC116401

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables cAMP binding  
    enables cAMP binding PubMed 
    enables cAMP binding  
    enables cAMP-dependent protein kinase inhibitor activity  
    enables cAMP-dependent protein kinase inhibitor activity  
    enables cAMP-dependent protein kinase regulator activity PubMed 
    enables cAMP-dependent protein kinase regulator activity  
    enables cAMP-dependent protein kinase regulator activity  
    enables kinase activity  
    enables protein binding PubMed 
    enables protein domain specific binding PubMed 
    enables protein kinase A catalytic subunit binding  
    enables protein kinase A catalytic subunit binding PubMed 
    enables protein kinase A catalytic subunit binding  
    enables protein kinase binding  
    enables ubiquitin protein ligase binding  
    Component Evidence Code Pubs
    part_of cAMP-dependent protein kinase complex  
    part_of cAMP-dependent protein kinase complex PubMed 
    part_of cAMP-dependent protein kinase complex  
    part_of cAMP-dependent protein kinase complex  
    located_in centrosome  
    located_in ciliary base  
    located_in cytoplasm  
    is_active_in cytosol  
    located_in dendrite PubMed 
    located_in dendritic shaft  
    located_in dendritic shaft  
    located_in dendritic spine  
    located_in dendritic spine  
    is_active_in glutamatergic synapse  
    located_in neuronal cell body PubMed 
    located_in perinuclear region of cytoplasm PubMed 
    located_in plasma membrane  
    located_in plasma membrane  
    is_active_in postsynapse  

    General protein information

    Preferred Names
    cAMP-dependent protein kinase type II-beta regulatory subunit
    Names
    Type II beta regulatory subunit of cAMP-dependent protein kinase
    protein kinase cAMP-dependent type 2 regulatory subunit beta
    protein kinase, cAMP dependent regulatory, type II beta
    protein kinase, cAMP-dependent, regulatory subunit type II beta
    NP_001025191.1
    XP_017449526.3
    XP_063117623.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001030020.1NP_001025191.1  cAMP-dependent protein kinase type II-beta regulatory subunit

      See identical proteins and their annotated locations for NP_001025191.1

      Status: VALIDATED

      Source sequence(s)
      BI298837, CB814252, CX569141, M12492
      UniProtKB/Swiss-Prot
      P12369
      UniProtKB/TrEMBL
      A6HB59
      Related
      ENSRNOP00000012415.6, ENSRNOT00000012415.8
      Conserved Domains (2) summary
      cd12104
      Location:343
      DD_RIIbeta_PKA; Dimerization/Docking domain of the Type II beta Regulatory subunit of cAMP-dependent protein kinase
      cd00038
      Location:274394
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      54291143..54381639 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017594037.3XP_017449526.3  cAMP-dependent protein kinase type II-beta regulatory subunit isoform X1

      UniProtKB/TrEMBL
      Q4KLG5
      Related
      ENSRNOP00000074658.1, ENSRNOT00000079719.3
    2. XM_063261553.1XP_063117623.1  cAMP-dependent protein kinase type II-beta regulatory subunit isoform X2

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