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    Gpat3 glycerol-3-phosphate acyltransferase 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 305166, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Gpat3provided by RGD
    Official Full Name
    glycerol-3-phosphate acyltransferase 3provided by RGD
    Primary source
    RGD:1565703
    See related
    EnsemblRapid:ENSRNOG00000085702 AllianceGenome:RGD:1565703
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Agpat9; AGPAT 10
    Summary
    Predicted to enable 1-acylglycerol-3-phosphate O-acyltransferase activity and glycerol-3-phosphate O-acyltransferase activity. Predicted to be involved in several processes, including glycerol-3-phosphate metabolic process; regulation of TOR signaling; and triglyceride biosynthetic process. Predicted to be located in endoplasmic reticulum membrane. Orthologous to human GPAT3 (glycerol-3-phosphate acyltransferase 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 92.7), Heart (RPKM 43.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Gpat3 in Genome Data Viewer
    Location:
    14p22
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (9018762..9072552, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (8715367..8768051, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (10343287..10396565, complement)

    Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene Set nuclear proto-oncogene, pseudogene 15 Neighboring gene uncharacterized LOC108352708 Neighboring gene uncharacterized LOC134481711 Neighboring gene abraxas 1, BRCA1 A complex subunit Neighboring gene mitochondrial ribosomal protein S18C

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Functional characterization of the human 1-acylglycerol-3-phosphate-O-acyltransferase isoform 10/glycerol-3-phosphate acyltransferase isoform 3. Sukumaran S, et al. J Mol Endocrinol, 2009 Jun. PMID 19318427, Free PMC Article
    2. Identification of a novel human lysophosphatidic acid acyltransferase, LPAAT-theta, which activates mTOR pathway. Tang W, et al. J Biochem Mol Biol, 2006 Sep 30. PMID 17002884
    3. Molecular identification of microsomal acyl-CoA:glycerol-3-phosphate acyltransferase, a key enzyme in de novo triacylglycerol synthesis. Cao J, et al. Proc Natl Acad Sci U S A, 2006 Dec 26. PMID 17170135, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Clone Names

    • MGC114395

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables 1-acylglycerol-3-phosphate O-acyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables 1-acylglycerol-3-phosphate O-acyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    NOT enables glycerol-3-phosphate O-acyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables glycerol-3-phosphate O-acyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables glycerol-3-phosphate O-acyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in CDP-diacylglycerol biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in glycerol-3-phosphate metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in phospholipid biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of TOR signaling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in triglyceride biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in triglyceride biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in triglyceride biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    glycerol-3-phosphate acyltransferase 3
    Names
    1-AGP acyltransferase 9
    1-AGPAT 9
    1-acyl-sn-glycerol-3-phosphate O-acyltransferase 10
    1-acyl-sn-glycerol-3-phosphate O-acyltransferase 9
    1-acylglycerol-3-phosphate O-acyltransferase 9
    GPAT-3
    LPAAT-theta
    lysophosphatidic acid acyltransferase theta
    NP_001020841.1
    XP_008768241.1
    XP_008768242.1
    XP_008768243.1
    XP_038947761.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001025670.1 → NP_001020841.1  glycerol-3-phosphate acyltransferase 3

      See identical proteins and their annotated locations for NP_001020841.1

      Status: PROVISIONAL

      Source sequence(s)
      BC097362
      UniProtKB/Swiss-Prot
      Q4V8J4
      UniProtKB/TrEMBL
      A6K5X4
      Related
      ENSRNOP00000101145.1, ENSRNOT00000172121.1
      Conserved Domains (1) summary
      cd07991
      Location:199 → 408
      LPLAT_LPCAT1-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LPCAT1-like

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086032.1 Reference GRCr8

      Range
      9018762..9072552 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008770020.4 → XP_008768242.1  glycerol-3-phosphate acyltransferase 3 isoform X1

      See identical proteins and their annotated locations for XP_008768242.1

      UniProtKB/Swiss-Prot
      Q4V8J4
      UniProtKB/TrEMBL
      A6K5X4
      Conserved Domains (1) summary
      cd07991
      Location:199 → 408
      LPLAT_LPCAT1-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LPCAT1-like

    2. XM_039091833.2 → XP_038947761.1  glycerol-3-phosphate acyltransferase 3 isoform X1

      UniProtKB/Swiss-Prot
      Q4V8J4
      UniProtKB/TrEMBL
      A6K5X4
      Conserved Domains (1) summary
      cd07991
      Location:199 → 408
      LPLAT_LPCAT1-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LPCAT1-like

    3. XM_008770021.4 → XP_008768243.1  glycerol-3-phosphate acyltransferase 3 isoform X1

      See identical proteins and their annotated locations for XP_008768243.1

      UniProtKB/Swiss-Prot
      Q4V8J4
      UniProtKB/TrEMBL
      A6K5X4
      Conserved Domains (1) summary
      cd07991
      Location:199 → 408
      LPLAT_LPCAT1-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LPCAT1-like

    4. XM_008770019.4 → XP_008768241.1  glycerol-3-phosphate acyltransferase 3 isoform X1

      See identical proteins and their annotated locations for XP_008768241.1

      UniProtKB/Swiss-Prot
      Q4V8J4
      UniProtKB/TrEMBL
      A6K5X4
      Conserved Domains (1) summary
      cd07991
      Location:199 → 408
      LPLAT_LPCAT1-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LPCAT1-like
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q4V8J4.1 GenPept UniProtKB/Swiss-Prot:Q4V8J4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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