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    Synj2bp synaptojanin 2 binding protein [ Rattus norvegicus (Norway rat) ]

    Gene ID: 64531, updated on 9-Dec-2024

    Summary

    Official Symbol
    Synj2bpprovided by RGD
    Official Full Name
    synaptojanin 2 binding proteinprovided by RGD
    Primary source
    RGD:69400
    See related
    EnsemblRapid:ENSRNOG00000006399 AllianceGenome:RGD:69400
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Omp25
    Summary
    Predicted to enable type II activin receptor binding activity. Involved in intracellular distribution of mitochondria. Located in mitochondrial outer membrane. Orthologous to human SYNJ2BP (synaptojanin 2 binding protein). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 228.4), Heart (RPKM 196.2) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Synj2bp in Genome Data Viewer
    Location:
    6q24
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (106920970..106958653, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (101189714..101227400, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (105224166..105261549, complement)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene cytochrome c oxidase assembly factor COX16 Neighboring gene uncharacterized LOC134479224 Neighboring gene a disintegrin and metalloprotease domain 4 Neighboring gene uncharacterized LOC103690066 Neighboring gene disintegrin and metalloproteinase domain-containing protein 21-like

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Interactions

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables protein binding PubMed 
    enables type II activin receptor binding  
    Process Evidence Code Pubs
    acts_upstream_of_or_within Rho protein signal transduction  
    involved_in intracellular distribution of mitochondria PubMed 
    involved_in negative regulation of ERK1 and ERK2 cascade  
    involved_in negative regulation of ERK1 and ERK2 cascade  
    involved_in negative regulation of activin receptor signaling pathway  
    involved_in negative regulation of angiogenesis  
    involved_in negative regulation of angiogenesis  
    involved_in negative regulation of endothelial cell migration  
    involved_in negative regulation of endothelial cell migration  
    involved_in negative regulation of endothelial cell proliferation  
    involved_in negative regulation of endothelial cell proliferation  
    involved_in negative regulation of sprouting angiogenesis  
    involved_in negative regulation of sprouting angiogenesis  
    involved_in positive regulation of activin receptor signaling pathway  
    involved_in positive regulation of protein localization to cell surface  
    involved_in positive regulation of receptor internalization  
    acts_upstream_of_or_within protein targeting  
    involved_in regulation of Notch signaling pathway  
    involved_in regulation of Notch signaling pathway  
    acts_upstream_of_or_within regulation of endocytosis  
    NOT involved_in regulation of receptor internalization  
    Component Evidence Code Pubs
    located_in cell surface  
    located_in membrane  
    located_in mitochondrial outer membrane PubMed 
    located_in mitochondrial outer membrane  
    located_in mitochondrion  

    General protein information

    Preferred Names
    synaptojanin-2-binding protein
    Names
    NPW16
    mitochondrial outer membrane protein 25
    outer membrane protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_022599.2NP_072121.2  synaptojanin-2-binding protein

      See identical proteins and their annotated locations for NP_072121.2

      Status: VALIDATED

      Source sequence(s)
      AF260258, JAXUCZ010000006
      UniProtKB/Swiss-Prot
      A0JN00, Q9WVJ4
      UniProtKB/TrEMBL
      A0A8I6AL95, A6JDM8
      Related
      ENSRNOP00000009119.5, ENSRNOT00000009122.8
      Conserved Domains (1) summary
      cd00992
      Location:1397
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      106920970..106958653 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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