Acsm2 acyl-CoA synthetase medium-chain family member 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Acsm2provided by RGD
Official Full Name: acyl-CoA synthetase medium-chain family member 2provided by RGD
Primary source: RGD:708383
See related: EnsemblRapid:ENSRNOG00000064951 AllianceGenome:RGD:708383
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: KS; Acsm2a
Summary: Predicted to enable benzoate-CoA ligase activity; fatty-acyl-CoA synthase activity; and medium-chain fatty acid-CoA ligase activity. Predicted to be involved in fatty acid biosynthetic process and medium-chain fatty-acyl-CoA metabolic process. Predicted to be located in mitochondrion. Predicted to be active in mitochondrial matrix. Orthologous to several human genes including ACSM2A (acyl-CoA synthetase medium chain family member 2A). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Restricted expression toward (RPKM 3318.8) See more
Orthologs: human all
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Genomic context

Location:: 1q35

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (183347705..183386453)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (173916368..173955116)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (189289957..189329007)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables CoA-ligase activity	IEA Inferred from Electronic Annotation more info
enables acid-thiol ligase activity	IEA Inferred from Electronic Annotation more info
enables benzoate-CoA ligase activity	ISS Inferred from Sequence or Structural Similarity more info
enables decanoate-CoA ligase activity	IEA Inferred from Electronic Annotation more info
enables fatty acid ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables fatty-acyl-CoA synthase activity	IBA Inferred from Biological aspect of Ancestor more info
enables medium-chain fatty acid-CoA ligase activity	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in acyl-CoA metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in biological_process	ND No biological Data available more info
involved_in fatty acid biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in fatty acid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in long-chain fatty acid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in medium-chain fatty-acyl-CoA metabolic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in mitochondrial matrix	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: acyl-coenzyme A synthetase ACSM2, mitochondrial

Names: acyl-CoA synthetase medium-chain family member 2A; benzoate--CoA ligase; butyrate--CoA ligase 2; butyryl-coenzyme A synthetase 2; kidney-specific protein KS; middle-chain acyl-CoA synthetase 2; xenobiotic/medium-chain fatty acid:CoA ligase

NP_653349.1

EC 6.2.1.2

EC 6.2.1.25

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.