Adgrg1 adhesion G protein-coupled receptor G1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Adgrg1provided by RGD
Full Name: adhesion G protein-coupled receptor G1provided by RGD
Primary source: RGD:628617
See related: EnsemblRapid:ENSRNOG00000014963 AllianceGenome:RGD:628617
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Gpr56
Summary: Predicted to enable several functions, including collagen binding activity; extracellular matrix binding activity; and heparin binding activity. Predicted to be involved in several processes, including G protein-coupled receptor signaling pathway; positive regulation of signal transduction; and seminiferous tubule development. Predicted to act upstream of or within cerebral cortex regionalization; hematopoietic stem cell homeostasis; and positive regulation of neural precursor cell proliferation. Predicted to be located in glial limiting end-foot. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in bilateral frontoparietal polymicrogyria and bilateral perisylvian polymicrogyria. Orthologous to human ADGRG1 (adhesion G protein-coupled receptor G1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Kidney (RPKM 296.4), Brain (RPKM 53.1) and 7 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 19p13

Exon count:: 21

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	19	NC_086037.1 (10009983..10047138, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	19	NC_051354.1 (10003963..10041122, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	19	NC_005118.4 (10423534..10460674, complement)

Chromosome 19 - NC_086037.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Adhesion G-protein coupled receptor 56 is required for 3T3-L1 adipogenesis.
Title: Adhesion G-protein coupled receptor 56 is required for 3T3-L1 adipogenesis.
GPR56 is expressed in the ependymal cell layer and in immature progenitor cells and that its expression is regulated by functional stimulation
Title: Stress and electroconvulsive seizure differentially alter GPR56 expression in the adult rat brain.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info
enables G protein-coupled receptor activity	ISO Inferred from Sequence Orthology more info
enables G protein-coupled receptor activity	ISS Inferred from Sequence or Structural Similarity more info
enables collagen binding	IEA Inferred from Electronic Annotation more info
enables collagen binding	ISO Inferred from Sequence Orthology more info
enables collagen binding	ISS Inferred from Sequence or Structural Similarity more info
enables extracellular matrix binding	IEA Inferred from Electronic Annotation more info
enables extracellular matrix binding	ISO Inferred from Sequence Orthology more info
enables extracellular matrix binding	ISS Inferred from Sequence or Structural Similarity more info
enables heparin binding	IBA Inferred from Biological aspect of Ancestor more info
enables heparin binding	IEA Inferred from Electronic Annotation more info
enables heparin binding	ISO Inferred from Sequence Orthology more info
enables heparin binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in Rho protein signal transduction	IEA Inferred from Electronic Annotation more info
involved_in Rho protein signal transduction	ISO Inferred from Sequence Orthology more info
involved_in Rho protein signal transduction	ISS Inferred from Sequence or Structural Similarity more info
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in angiogenesis	IEA Inferred from Electronic Annotation more info
involved_in angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in angiogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in brain development	ISO Inferred from Sequence Orthology more info
involved_in cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in cell adhesion	ISS Inferred from Sequence or Structural Similarity more info
involved_in cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in cell migration	ISO Inferred from Sequence Orthology more info
involved_in cell migration	ISS Inferred from Sequence or Structural Similarity more info
involved_in cell surface receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in cerebral cortex radial glia-guided migration	ISO Inferred from Sequence Orthology more info
involved_in cerebral cortex radial glia-guided migration	ISS Inferred from Sequence or Structural Similarity more info
involved_in cerebral cortex regionalization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cerebral cortex regionalization	ISO Inferred from Sequence Orthology more info
involved_in hematopoietic stem cell homeostasis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within hematopoietic stem cell homeostasis	ISO Inferred from Sequence Orthology more info
involved_in layer formation in cerebral cortex	IEA Inferred from Electronic Annotation more info
involved_in layer formation in cerebral cortex	ISO Inferred from Sequence Orthology more info
involved_in layer formation in cerebral cortex	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of cell population proliferation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell population proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of neuron migration	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of neuron migration	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of neuron migration	ISS Inferred from Sequence or Structural Similarity more info
involved_in nervous system development	IEA Inferred from Electronic Annotation more info
involved_in neural precursor cell proliferation	IEA Inferred from Electronic Annotation more info
acts_upstream_of neural precursor cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of Rho protein signal transduction	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of Rho protein signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of Rho protein signal transduction	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell adhesion	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of neural precursor cell proliferation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of neural precursor cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of vascular endothelial growth factor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of vascular endothelial growth factor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of vascular endothelial growth factor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in seminiferous tubule development	IEA Inferred from Electronic Annotation more info
involved_in seminiferous tubule development	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in glial limiting end-foot	IEA Inferred from Electronic Annotation more info
located_in glial limiting end-foot	ISO Inferred from Sequence Orthology more info
located_in glial limiting end-foot	ISS Inferred from Sequence or Structural Similarity more info
located_in membrane raft	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: adhesion G-protein coupled receptor G1

Names: G-protein coupled receptor 56

NP_689448.2

EC 2.7.11.25

XP_008770486.1

EC 2.7.11.25

XP_008770489.1

EC 2.7.11.25

XP_008770492.1

EC 2.7.11.25

XP_038953455.1

EC 2.7.11.25

XP_038953456.1

EC 2.7.11.25

XP_063133896.1

EC 2.7.11.25

XP_063133897.1

EC 2.7.11.25

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_152242.2 → NP_689448.2 adhesion G-protein coupled receptor G1 precursor

See identical proteins and their annotated locations for NP_689448.2

Status: VALIDATED

Source sequence(s)

CB766806, CK482497, CO557428, CV116515, EX488169, JAXUCZ010000019

UniProtKB/Swiss-Prot

Q8K3V3

UniProtKB/TrEMBL

A0A0G2JSP0

Related

ENSRNOP00000020921.3, ENSRNOT00000020921.8

Conserved Domains (5) summary

pfam01825
Location:345 → 388

GPS; GPCR proteolysis site, GPS, motif

pfam18587
Location:29 → 162

PLL; PTX/LNS-Like (PLL) domain

pfam18619
Location:173 → 220

GAIN_A; GPCR-Autoproteolysis-INducing (GAIN) subdomain A

cd14964
Location:402 → 427

7tm_GPCRs; TM helix 1 [structural motif]

cl28897
Location:400 → 667

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086037.1 Reference GRCr8

Range

10009983..10047138 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_008772264.4 → XP_008770486.1 adhesion G-protein coupled receptor G1 isoform X2

See identical proteins and their annotated locations for XP_008770486.1

UniProtKB/Swiss-Prot

Q8K3V3

UniProtKB/TrEMBL

F1LMW3

Related

ENSRNOP00000071610.2, ENSRNOT00000088048.3

Conserved Domains (2) summary

pfam01825
Location:349 → 393

GPS; GPCR proteolysis site, GPS, motif

cl21561
Location:408 → 653

7tm_4; Olfactory receptor
XM_063277826.1 → XP_063133896.1 adhesion G-protein coupled receptor G1 isoform X1

UniProtKB/Swiss-Prot

Q8K3V3

Related

ENSRNOP00000106989.1, ENSRNOT00000134765.1
XM_008772270.4 → XP_008770492.1 adhesion G-protein coupled receptor G1 isoform X3

See identical proteins and their annotated locations for XP_008770492.1

UniProtKB/Swiss-Prot

Q8K3V3

UniProtKB/TrEMBL

A0A0G2JSP0

Conserved Domains (5) summary

pfam01825
Location:345 → 388

GPS; GPCR proteolysis site, GPS, motif

pfam18587
Location:29 → 162

PLL; PTX/LNS-Like (PLL) domain

pfam18619
Location:173 → 220

GAIN_A; GPCR-Autoproteolysis-INducing (GAIN) subdomain A

cd14964
Location:402 → 427

7tm_GPCRs; TM helix 1 [structural motif]

cl28897
Location:400 → 667

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
XM_008772267.4 → XP_008770489.1 adhesion G-protein coupled receptor G1 isoform X3

See identical proteins and their annotated locations for XP_008770489.1

UniProtKB/Swiss-Prot

Q8K3V3

UniProtKB/TrEMBL

A0A0G2JSP0

Conserved Domains (5) summary

pfam01825
Location:345 → 388

GPS; GPCR proteolysis site, GPS, motif

pfam18587
Location:29 → 162

PLL; PTX/LNS-Like (PLL) domain

pfam18619
Location:173 → 220

GAIN_A; GPCR-Autoproteolysis-INducing (GAIN) subdomain A

cd14964
Location:402 → 427

7tm_GPCRs; TM helix 1 [structural motif]

cl28897
Location:400 → 667

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
XM_039097527.2 → XP_038953455.1 adhesion G-protein coupled receptor G1 isoform X3

UniProtKB/Swiss-Prot

Q8K3V3

UniProtKB/TrEMBL

A0A0G2JSP0

Conserved Domains (5) summary

pfam01825
Location:345 → 388

GPS; GPCR proteolysis site, GPS, motif

pfam18587
Location:29 → 162

PLL; PTX/LNS-Like (PLL) domain

pfam18619
Location:173 → 220

GAIN_A; GPCR-Autoproteolysis-INducing (GAIN) subdomain A

cd14964
Location:402 → 427

7tm_GPCRs; TM helix 1 [structural motif]

cl28897
Location:400 → 667

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
XM_039097528.2 → XP_038953456.1 adhesion G-protein coupled receptor G1 isoform X3

UniProtKB/Swiss-Prot

Q8K3V3

UniProtKB/TrEMBL

A0A0G2JSP0

Conserved Domains (5) summary

pfam01825
Location:345 → 388

GPS; GPCR proteolysis site, GPS, motif

pfam18587
Location:29 → 162

PLL; PTX/LNS-Like (PLL) domain

pfam18619
Location:173 → 220

GAIN_A; GPCR-Autoproteolysis-INducing (GAIN) subdomain A

cd14964
Location:402 → 427

7tm_GPCRs; TM helix 1 [structural motif]

cl28897
Location:400 → 667

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
XM_063277827.1 → XP_063133897.1 adhesion G-protein coupled receptor G1 isoform X3

UniProtKB/Swiss-Prot

Q8K3V3

UniProtKB/TrEMBL

A0A0G2JSP0