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    Mpnd MPN domain containing [ Rattus norvegicus (Norway rat) ]

    Gene ID: 681944, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Mpndprovided by RGD
    Official Full Name
    MPN domain containingprovided by RGD
    Primary source
    RGD:1589335
    See related
    EnsemblRapid:ENSRNOG00000048282 AllianceGenome:RGD:1589335
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable metallopeptidase activity and polyubiquitin modification-dependent protein binding activity. Predicted to be involved in double-strand break repair. Predicted to be part of BRCA1-A complex and BRISC complex. Orthologous to human MPND (MPN domain containing). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 272.9), Liver (RPKM 186.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Mpnd in Genome Data Viewer
    Location:
    9q11
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (926714..933620)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (839473..846446)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (11055370..11061611, complement)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene fibronectin type III and SPRY domain containing 1 Neighboring gene signal transducing adaptor family member 2 Neighboring gene SH3 domain containing GRB2 like 1, endophilin A2 Neighboring gene chromatin assembly factor 1 subunit A Neighboring gene UBX domain protein 6

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metallopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables polyubiquitin modification-dependent protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in double-strand break repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of BRCA1-A complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of BRISC complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    MPN domain-containing protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001085406.1 → NP_001078875.1  MPN domain-containing protein

      See identical proteins and their annotated locations for NP_001078875.1

      Status: VALIDATED

      Source sequence(s)
      BC101893, CB768016
      UniProtKB/TrEMBL
      A0A8I5ZX75, B0BMT2, M0R430
      Related
      ENSRNOP00000064107.4, ENSRNOT00000074075.4
      Conserved Domains (2) summary
      cd08067
      Location:252 → 436
      MPN_2A_DUB; Mov34/MPN/PAD-1 family: Histone H2A deubiquitinase
      pfam18755
      Location:57 → 157
      RAMA; Restriction Enzyme Adenine Methylase Associated

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      926714..933620
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063267727.1 → XP_063123797.1  MPN domain-containing protein isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZX75, A0A8J8XFB8

    2. XM_063267728.1 → XP_063123798.1  MPN domain-containing protein isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZX75, B0BMT2, M0R430

    3. XM_039084206.2 → XP_038940134.1  MPN domain-containing protein isoform X3

      UniProtKB/TrEMBL
      A0A8I5ZX75
      Conserved Domains (2) summary
      cd08067
      Location:252 → 431
      MPN_2A_DUB; Mov34/MPN/PAD-1 family: Histone H2A deubiquitinase
      pfam18755
      Location:57 → 157
      RAMA; Restriction Enzyme Adenine Methylase Associated

    4. XM_039084207.2 → XP_038940135.1  MPN domain-containing protein isoform X4

      UniProtKB/TrEMBL
      A0A8I5ZX75
      Conserved Domains (2) summary
      cd08067
      Location:252 → 430
      MPN_2A_DUB; Mov34/MPN/PAD-1 family: Histone H2A deubiquitinase
      pfam18755
      Location:57 → 157
      RAMA; Restriction Enzyme Adenine Methylase Associated

    5. XM_039084208.2 → XP_038940136.1  MPN domain-containing protein isoform X6

      Conserved Domains (2) summary
      pfam18755
      Location:57 → 157
      RAMA; Restriction Enzyme Adenine Methylase Associated
      cl13996
      Location:252 → 320
      MPN; Mpr1p, Pad1p N-terminal (MPN) domains

    6. XM_063267730.1 → XP_063123800.1  MPN domain-containing protein isoform X7

    7. XM_063267729.1 → XP_063123799.1  MPN domain-containing protein isoform X5

    RNA

    1. XR_005488964.2 RNA Sequence

    2. XR_005488966.2 RNA Sequence

    3. XR_005488965.2 RNA Sequence

    4. XR_010054631.1 RNA Sequence

    5. XR_010054630.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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